Application of blood stem cells (CD34+ and CD45)/concentrated growth factors (CGF) in guided bone regeneration (GBR) and guided tissue regeneration (GTR) in conjunction with mls laser and piezoelectric surgery

Doan, Ninh; Reher, Peter; Duong, Q. T.; Wang, Gui; Truong, L.

doi:10.1016/j.ijom.2019.03.190

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The novel use of CGF for mineralized/soft tissue regeneration in maxillofacial medicine was relatively new with only 27 human studies 35–61 included in this review. All types of studies were included to perform a thorough summary of clinical application.…”

Section: Discussionmentioning

confidence: 99%

“…Although the implant success rate was very high after using CGF, it is difficult to compare the results of different literature with high heterogeneity in study design types, CGF preparation protocols, and outcomes measurement. To date, 4 case series [35][36][37][38] reported the effectiveness of CGF used alone or in combination with sticky bone/Bio-Oss on bone regeneration and reconsolidation without any postoperative discomforts. Four retrospective studies [39][40][41][42] reported the effectiveness of CGF used alone on promoting new bone formation with vertical bone gains of 9.53 mm, 8.23 mm, 9.21 mm, and 6.14 mm, respectively.…”

Section: Search Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine

Chen

Wan

Yang

et al. 2020

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Different strategies have been utilized to facilitate mineralized/soft tissues. Concentrated growth factor (CGF) emerges as a promising biomaterial for regenerative therapy due to high levels of platelets, growth factors, and nucleated cells entrapped in the fibrin scaffold. This review aimed to collect extensive studies on CGF used in maxillofacial regenerative medicine, discussing current obstacles, and expressing some considerations of CGF use. Articles were retrieved systematically without time limitation. In total, 27 human studies were included and separated accordingly. In general, CGF has been most evaluated in implant related therapy and maxillofacial bone regeneration where a majority of articles have revealed favorable outcomes. Little studies have supported the effects on improving probing periodontal depth reductions and clinical attachment level gains for intrabony and furcation defect regeneration. Very little data with high-level evidence was available directly to investigate its effects on the soft tissue regeneration and postoperative complications reduction. The evidence supporting the clinical efficacy of CGF in maxillofacial regenerative medicine is limited. Some conflicting results are worrisome. In addition, the characterization of CGF preparation protocols and CGF's components was not performed in most studies. Further studies should make a consensus on standardized end-product of CGF including characterization of protocols and optimal ratio of CGF' components. Defined algorithms and evidence-based protocols for the clinical use of CGF should be also available.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Search Outcomesmentioning

confidence: 99%

Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine

Chen

Wan

Yang

et al. 2020

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

show abstract

“…Avoiding immunoreactions, cross‐contamination, and ethical concerns make CGF a very popular product, among all platelet concentrates, for tissue repair (Zhang & Ai, ). Many clinical studies actually focus on the effects of CGF in bone regeneration (Brignardello‐Petersen, ; Doan, Reher, Duong, Wang, & Truong, ; Özveri Koyuncu, Işık, Özden Yüce, Günbay, & Günbay, ; Xu, Qiu, et al, ). With the increasing use of CGF, questions about its FDA approval are raised.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo effects of concentrated growth factor on cells and tissues

Tabatabaei

Aghamohammadi

Tayebi

2020

J Biomedical Materials Res

View full text Add to dashboard Cite

This article reviews the biological outcome of the concentrated growth factor (CGF), a new platelet derivative used for tissue regeneration, in published articles related to the use of this product in basic and clinical studies. An electronic literature research using PubMed and SCOPUS was performed using combination of keywords: “concentrated growth factor” (OR “CGF”), AND “stem cells,” AND “cells” OR “cell proliferation” OR “cell migration” OR “cell differentiation,” AND “repair” OR “survival” OR “revitalization,” AND “tissue” OR “bone.” Forty‐five articles that were published between 2012 and 2020 met the inclusion criteria. These studies have used CGF as fresh solid form, freeze‐dried, membrane, extract, or exudate. Most studies demonstrate the positive effects of CGF in a dose‐dependent manner under certain concentrations. Studies comparing CGF with other platelet concentrates, report lower efficiency, no statistically significant differences, or better results for CGF. Combination of CGF with stem cells and biomaterials significantly improves bone regeneration and the effect of allograft or collagen membrane is better than CGF alone. For a better examination of the biological outcomes of CGF, the standardization of CGF preparation regarding the choice of the test tube material for blood collection, the required volume of blood, the necessary count of platelets in CGF, and the most appropriate type of CGF are recommended.

show abstract

Concentrated growth factor intradermal injection assisted super‐thin flap expansion for repairing skin defects: A randomized, single blinded, split‐site study

Liang,

Yang,

Song

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

BackgroundThe super‐thin skin flap formed by skin and soft tissue expansion has large area and good ductility, so it can be used to repair skin defects. However, because the flap is thin, the blood flow in the dermis of the super‐thin expanded flap is weakened, and flap rupture and necrosis after secondary flap transfer may occur.ObjectiveTo compare the skin thickness difference between the expanded ultrathin flaps injected with concentrated growth factor (CGF) and the blank group or saline group.MethodsFrom June 2021 to December 2023, 10 patients (44 sites) with large‐area scars or skin tumors were treated, and a single center half randomized controlled trial was conducted. The test site of expander implantation was divided into three groups: intradermal injection of CGF group, normal saline group and blank group. The same amount of expansion was performed every 1–2 weeks, and CGF or normal saline was injected into the dermis every 4 weeks, a total of three times. After 2–3 months of expansion, color Doppler ultrasound was used to measure the skin thickness of each group.ResultsCompared with the blank group, the skin thickness of CGF group was 1.75 ± 0.08 mm, and that of BLA blank group was 1.42 ± 0.07 mm, with statistically significant difference (p < 0.0001); In the other group, compared with the saline group, the skin thickness of the CGF group was 1.54 ± 0.08 mm, and the average skin thickness of the saline group was 1.40 ± 0.08 mm, with significant difference between the two groups (p = 0.0067).ConclusionCGF intradermal injection can increase the skin thickness of super‐thin skin flap in the process of soft tissue expansion, which is a safe and effective auxiliary method of skin expansion.

show abstract

Application of blood stem cells (CD34+ and CD45)/concentrated growth factors (CGF) in guided bone regeneration (GBR) and guided tissue regeneration (GTR) in conjunction with mls laser and piezoelectric surgery

Cited by 4 publications

References 0 publications

Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine

Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine

In vitro and in vivo effects of concentrated growth factor on cells and tissues

Concentrated growth factor intradermal injection assisted super‐thin flap expansion for repairing skin defects: A randomized, single blinded, split‐site study

Contact Info

Product

Resources

About