Application of Bioprinting in Ophthalmology

Wang, Yanfang; Wang, Jiejie; Ji, Ziyu; Yan, Wei; Hong, Zhonghua; Huang, Wenhua; Liu, Huan

doi:10.18063/ijb.v8i2.552

Cited by 16 publications

(9 citation statements)

References 88 publications

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“…Next-generation organoid engineering approaches seek to address these limitations through innovative biomaterials, bioreactors, co-culture, and microfluidic systems to generate enhanced organoids [ 15 – 20 ]. Quadruple-layered retina-on-a-chip devices with RPE have achieved improved morphology [ 40 ], while bioprinting holds promise to pattern cells and matrix into higher order structures [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Zhao,

Yan

2023

Stem Cell Rev and Rep

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Retinal diseases are leading causes of blindness globally. Developing new drugs is of great significance for preventing vision loss. Current drug discovery relies mainly on two-dimensional in vitro models and animal models, but translation to human efficacy and safety is biased. In recent years, the emergence of retinal organoid technology platforms, utilizing three-dimensional microenvironments to better mimic retinal structure and function, has provided new platforms for exploring pathogenic mechanisms and drug screening. This review summarizes the latest advances in retinal organoid technology, emphasizing its application advantages in high-throughput drug screening, efficacy and toxicity evaluation, and translational medicine research. The review also prospects the combination of emerging technologies such as organ-on-a-chip, 3D bioprinting, single cell sequencing, gene editing with retinal organoid technology, which is expected to further optimize retinal organoid models and advance the diagnosis and treatment of retinal diseases.

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Section: Discussionmentioning

confidence: 99%

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Zhao,

Yan

2023

Stem Cell Rev and Rep

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“…An ideal model needs to have cells with appropriate polarity, tight junction protein expression, proper attachment to Bruch’s membrane, and the release of hormones such as human vascular endothelial growth factor (hVEGF) at physiologically similar levels, among other things. Several bioprinting technologies exist and can be used to help develop these retinal models [ 60 ].…”

Section: Retinal Applicationsmentioning

confidence: 99%

Towards Precision Ophthalmology: The Role of 3D Printing and Bioprinting in Oculoplastic Surgery, Retinal, Corneal, and Glaucoma Treatment

Wu,

Tabari,

Mazerolle

et al. 2024

Biomimetics

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In the forefront of ophthalmic innovation, biomimetic 3D printing and bioprinting technologies are redefining patient-specific therapeutic strategies. This critical review systematically evaluates their application spectrum, spanning oculoplastic reconstruction, retinal tissue engineering, corneal transplantation, and targeted glaucoma treatments. It highlights the intricacies of these technologies, including the fundamental principles, advanced materials, and bioinks that facilitate the replication of ocular tissue architecture. The synthesis of primary studies from 2014 to 2023 provides a rigorous analysis of their evolution and current clinical implications. This review is unique in its holistic approach, juxtaposing the scientific underpinnings with clinical realities, thereby delineating the advantages over conventional modalities, and identifying translational barriers. It elucidates persistent knowledge deficits and outlines future research directions. It ultimately accentuates the imperative for multidisciplinary collaboration to enhance the clinical integration of these biotechnologies, culminating in a paradigm shift towards individualized ophthalmic care.

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“…Additive technologies can also allow for the production of various lenses [18] and innovative and multifunctional components, which can simplify, optimize and miniaturize optical systems, being able to perfect medical instruments, equipment for scientific research or household equipment. It is also worth mentioning the efforts and special progress made in the ophthalmological field, using bioprinting for corneal reconstruction and regeneration or the creation of other eye tissues such as retina or conjunctiva [19][20][21]. Such research is in the advanced testing/research phase and has great prospects for use in the field in the future, bringing important contributions to the development of this medical area and major benefits for people with ocular disabilities.…”

Section: Complete System Descriptionmentioning

confidence: 99%

The Design and Testing of an Additive Manufacturing-Obtained Compliant Mechanism for the Complex Personalisation of Lenses in Clinical Optometry

Constantin,

Comeagă,

Grămescu

et al. 2023

Applied Sciences

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The precision needed in optometric measurements for the correct customization of progressive lenses usually falls short of what is required for accurate prescriptions. This usually stems from the fact that most measurements are obtained using outdated methods, employing either rulers or protractors. While there is equipment available for precise measurements, the cost of purchase and ownership is usually prohibitive. In this context, due to constant progress in high-resolution cameras along with the processing power of handheld devices, another solution has presented itself in different iterations in the past decade, as put forward by different manufacturers of optical lenses. Such a system comprises a mobile computing device with image capture and processing capabilities (tablet or smartphone), along with a marker support system to be mounted on the user’s glasses frames. Aside from cost, the ease of implementation and usage, the advantage of such a system is that the parameters, as measured, allow for better customization, since the eyewear is already in the position in which it will be used. It allows the optometrist to measure parameters such as interpupillary distance, pantoscopic angle and the curvature of the eyewear in relation to the user’s own specific shape and size. This paper proposes a model of a marker support system that is easy to use, precise, low in cost and has minimal impact on the measurements obtained by the optometrist. As such, this paper examines the steps for determining the shape needed for supports in relation to the measurements that need to be taken; a finite element analysis of the support was proposed, along with various tests and modifications that were made to the device until a specific shape and material combination was found that satisfied all of the parameters required. An experimental model of the system was produced and tested on a wide variety of glasses frames with good results, as presented in the following work.

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Application of Bioprinting in Ophthalmology

Cited by 16 publications

References 88 publications

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Towards Precision Ophthalmology: The Role of 3D Printing and Bioprinting in Oculoplastic Surgery, Retinal, Corneal, and Glaucoma Treatment

The Design and Testing of an Additive Manufacturing-Obtained Compliant Mechanism for the Complex Personalisation of Lenses in Clinical Optometry

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