Application of biodegradable superabsorbent hydrogel composite based on Gum ghatti-co-poly(acrylic acid-aniline) for controlled drug delivery

Sharma, Kashma; Kumar, Vijay; Chaudhary, Babulal; Kaith, Balbir Singh; Kalia, Susheel; Swart, H.C.

doi:10.1016/j.polymdegradstab.2015.12.021

Cited by 66 publications

(28 citation statements)

References 52 publications

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“…The suspension-gelation method is conducted using only low toxic and inexpensive physically crosslinked microcapsules such as calcium alginate gel. Graft copolymerization resulting in development of physical and chemical properties of hydrogels makes them excellent smart materials [16][17][18].…”

Section: Hydrogels Preparationmentioning

confidence: 99%

“…These microbial poly(amino acid)s are water soluble, hydrodegradable and biodegradable [19]. Free radical polymerization of different vinyl monomers and aniline onto gum ghatti (Gg) under dissimilar reaction conditions was also described [18]. Polyaniline (PANI) is an attractive conductive polymer because of its simple methods of synthesis, high stability, variable structure as well as unique optical, magnetic, electrical, electrochemical and electromechanical properties.…”

Section: Hydrogels Preparationmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels from Fundaments to Application

Kołodyńska¹,

Skiba²,

Górecka³

et al. 2016

Emerging Concepts in Analysis and Applications of Hydrogels

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Polymer superabsorbents commonly known as hydrogels are cross-linked highly molecular compounds able to absorb water from physicochemical fluids in the amounts from 10-fold to 100-fold larger than their dry mass. Numerous investigations have shown that they can help reduce irrigation water consumption, lower the death rate of plants, improve fertilizer retention in soil and increase plant growth rate. Besides water absorption and retention, the superabsorbent polymers have many advantages over conventional ones, such as a sustained supply of nutrition to plants for a longer time, thus increasing the phosphate fertilizer use efficiency and decreasing application frequency. The aim of this study is to investigate the influence of chemical conditions on hydrogels, kinetic and absorption behaviour towards metal ions in the presence of the chelating agent of a new generation. In this group, there are IDS, EDDS, GLDA, MGDA, etc. In the chapter, the research on the applicability of the effective absorption of metal complexes with a biodegradable complexing agent will be presented. The possibility of the preparation of slow-release fertilizers of controlled activity of a new generation in such system will also be discussed.

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Section: Hydrogels Preparationmentioning

confidence: 99%

Section: Hydrogels Preparationmentioning

confidence: 99%

Hydrogels from Fundaments to Application

Kołodyńska¹,

Skiba²,

Górecka³

et al. 2016

Emerging Concepts in Analysis and Applications of Hydrogels

View full text Add to dashboard Cite

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“…Time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) is frequently used in surface chemistry characterization of bioresorbable polymers and in monitoring the changes induced by degradation processes . TOF‐SIMS has also recently been used to understand physiochemical surface interactions between degradable biopolymers and biological environments . SIMS can work in the static mode (SSIMS) or dynamic mode (DSIMS).…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Rizzarelli

Rapisarda

Valenti

2020

Rapid Comm Mass Spectrometry

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A detailed characterization of polymeric matrices and appropriate degradation monitoring techniques are required to sustain the development of new materials as well as to enlarge the applications of the old ones. In fact, polymer analysis is essential for the clarification of the intrinsic relationship between structure and properties that ascertains the industrial applications in diverse fields. In bioresorbable and biodegradable polymers, the role of analytical methods is dual since it is pointed both at the polymeric matrices and at degradation tracking. The structural architectures, the mechanical and morphological properties, and the degradation rate, are of outstanding importance for a specific application. In some cases, the complexity of the polymer structure, the processes of decomposition or the low concentration of the degradation products need the concurrent use of different complementary analytical techniques to give detailed information of the reactions taking place. Several analytical methods are used in bioresorbable polymer development and degradation tracking. Among them, mass spectrometry (MS) plays an essential role and it is used to refine polymer syntheses, for its high sensitivity, to highlight degradation mechanism by detecting compounds present in trace amounts, or to track the degradation product profile and to study drug release. In fact, elucidation of reaction mechanisms and polymer structure, attesting to the purity and detecting defects as well as residual catalysts, in biodegradable and bioresorbable polymers, requires sensitive analytical characterization methods that are essential in providing an assurance of safety, efficacy and quality. This review aims to provide an overview of the MS strategies used to support research and development of resorbable polymers as well as to investigate their degradation mechanisms. It is focused on the most significant studies concerning synthetic bioresorbable matrices (polylactide, polyglycolide and their copolymers, polyhydroxybutyrate, etc.), published in the last ten years.

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“…Sharma et al . synthesized a biodegradable superabsorbent gum ghatti‐ co ‐poly(AAc–aniline) hydrogel composite for colon‐specific controlled drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B₁₂

Nath¹,

Chowdhury²,

Ali³

et al. 2019

J of Applied Polymer Sci

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Gelatin (Ge)‐g‐poly(acrylic acid‐co‐acrylamide) and montmorillonite (MMT)‐clay‐based nanocomposite hydrogels were fabricated to study the controlled release of vitamin B12. Polymeric hydrogels were characterized with Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). FTIR spectroscopy confirmed the grafting of partially neutralized acrylic acid on a Ge backbone. The incorporation of MMT fillers inside the nanocomposite hydrogels and their increased crystallinity were established by XRD analysis. The rough surface morphologies of the composite hydrogels shown by SEM resulted from the assimilation of MMT inside the same. TEM confirmed the formation of nanosized composites. The average length and width of the MMT platelets were found to be 184.37 and 20.48 nm, respectively. The maximum swelling of the hydrogel was 375 g/g, and the results were established with Design‐Expert software. The biodegradability of the nanocomposite increased in comparison to that of the copolymer hydrogel. Biocompatibility and cytotoxicity studies were also performed. During different time intervals, the controlled release of vitamin B12 in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) was evaluated with a UV–visible spectrophotometer; this resulted in different controlled release curves. The release in AGF was 42%, and in AIF, the cumulative release was 80% over 6 h. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47596.

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Application of biodegradable superabsorbent hydrogel composite based on Gum ghatti-co-poly(acrylic acid-aniline) for controlled drug delivery

Cited by 66 publications

References 52 publications

Hydrogels from Fundaments to Application

Hydrogels from Fundaments to Application

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B₁₂

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Application of biodegradable superabsorbent hydrogel composite based on Gum ghatti-co-poly(acrylic acid-aniline) for controlled drug delivery

Cited by 66 publications

References 52 publications

Hydrogels from Fundaments to Application

Hydrogels from Fundaments to Application

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B12

Contact Info

Product

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Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B₁₂