Application of biocompatible and ultrastable superparamagnetic iron(<scp>iii</scp>) oxide nanoparticles doped with magnesium for efficient magnetic fluid hyperthermia in lung cancer cells

Nowicka, Anna M.; Ruzycka-Ayoush, Monika; Kasprzak, Artur; Kowalczyk, Agata; Bamburowicz-Klimkowska, Magdalena; Sikorska, Monika; Sobczak, Kamil; Donten, Mikołaj; Ruszczyńska, Anna; Nowakowska, Julita; Grudziński, Ireneusz P.

doi:10.1039/d3tb00167a

Cited by 5 publications

(6 citation statements)

References 78 publications

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“…Good biosafety and stability are the prerequisites for the further development and application of nanoparticles [43][44][45]. Cytotoxicity, blood biochemistry and HE results showed that the nanoparticles did not exhibit significant cellular damage, liver and kidney toxicity, and pathological damage to major metabolic organs, and the one-week monitoring of the T 2 relaxation rate showed that the relaxation rate was only slightly reduced, suggesting that the nanoparticles have good short-term stability.…”

Section: Discussionmentioning

confidence: 99%

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Yin,

Gao,

Zhang

et al. 2024

Biomed. Mater.

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This study developed a probe Fe3O4-Cy5.5-trastuzumab with fluorescence and magnetic resonance imaging functions that can target breast cancer with high HER2 expression, aiming to provide a new theoretical method for the diagnosis of early breast cancer.Methods:Fe3O4-Cy5.5-trastuzumab nanoparticles were combined with Fe3O4 for T2 imaging and Cy5.5 for near-infrared imaging, and coupled with trastuzumab for HER2 targeting. We characterized the nanoparticles used transmission electron microscopy, hydration particle size, Zeta potential, UV and fourier transform infrared spectroscopy, and examined its magnetism, fluorescence, and relaxation rate related properties. CCK-8 and blood biochemistry analysis evaluated the biosafety and stability of the nanoparticles, and validated the targeting ability of Fe3O4-Cy5.5 trastuzumab nanoparticles through in vitro and in vivo cell and animal experiments.Results: Characterization results showed the successful synthesis of Fe3O4-Cy5.5-trastuzumab nanoparticles with a diameter of 93.72±6.34 nm. The nanoparticles showed a T2 relaxation rate 42.29 mM-1s-1, magnetic saturation strength of 27.58 emg/g. Laser confocal and flow cytometry uptake assay showed that the nanoparticles could effectively target HER2 expressed by breast cancer cells. As indicated by in vitro and in vivo studies, Fe3O4-Cy5.5-trastuzumab were specifically taken up and effectively aggregated to tumor regions with prominent NIRF/MR imaging properties. CCK-8, blood biochemical analysis and histological results suggested Fe3O4-Cy5.5-trastuzumab that exhibited low toxicity to major organs and good in vivo biocompatibility. The prepared Fe3O4-Cy5.5-trastuzumab exhibited excellent targeting, NIRF/MR imaging performance. It is expected to serve as a safe and effective diagnostic method that lays a theoretical basis for the effective diagnosis of of early breast cancer.Conclusion: This study successfully prepared a kind of nanoparticles with near-infrared fluorescence imaging and T2 imaging properties, which is expected to serve as a new theory and strategy for early detection of breast cancer.KeywordsBreast cancer ; HER2 ;Trastuzumab ;T2 imaging properties; Near infrared fluorescence imaging;Early detection 

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Section: Discussionmentioning

confidence: 99%

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Yin,

Gao,

Zhang

et al. 2024

Biomed. Mater.

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“…MFH is a potential treatment technique that uses magnetic doped-IONPs exposed to an alternating magnetic field to heat malignant tissues to 40−43 °C. 92 Doped-IONPs also exhibited controlled drug delivery, enhanced targeted delivery, improved stability and biocompatibility. 93,94 In addition to that doped-IONPs are becoming essential for photodynamic therapy carrier due to its ability to penetrate deeply.…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…A recent study by Nowicka et al (2023) reported magnetic IONPs doped with magnesium have demonstrated outstanding potential for magnetic fluid hyperthermia (MFH) in lung cancer treatments. MFH is a potential treatment technique that uses magnetic doped-IONPs exposed to an alternating magnetic field to heat malignant tissues to 40–43 °C . Doped-IONPs also exhibited controlled drug delivery, enhanced targeted delivery, improved stability and biocompatibility. , In addition to that doped-IONPs are becoming essential for photodynamic therapy carrier due to its ability to penetrate deeply .…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…88,90 IONPs doped with transition metal are also employed to minimize the size of superparamagnetic contrast agents while retaining an excellent MRI contrast efficiency. 91 A recent study by Nowicka et al (2023) 92 reported magnetic IONPs doped with magnesium have demonstrated outstanding potential for magnetic fluid hyperthermia (MFH) in lung cancer treatments. MFH is a potential treatment technique that uses magnetic doped-IONPs exposed to an alternating magnetic field to heat malignant tissues to 40−43 °C.…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

See 2 more Smart Citations

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Tasnim,

Ferdous,

Rumon

et al. 2023

ACS Omega

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Antibiotic resistance (AMR) is one of the pressing global public health concerns and projections indicate a potential 10 million fatalities by the year 2050. The decreasing effectiveness of commercially available antibiotics due to the drug resistance phenomenon has spurred research efforts to develop potent and safe antimicrobial agents. Iron oxide nanoparticles (IONPs), especially when doped with metals, have emerged as a promising avenue for combating microbial infections. Like IONPs, the antimicrobial activities of doped-IONPs are also linked to their surface charge, size, and shape. Doping metals on nanoparticles can alter the size and magnetic properties by reducing the energy band gap and combining electronic charges with spins. Furthermore, smaller metal-doped nanoparticles tend to exhibit enhanced antimicrobial activity due to their higher surface-to-volume ratio, facilitating greater interaction with bacterial cells. Moreover, metal doping can also lead to increased charge density in magnetic nanoparticles and thereby elevate reactive oxygen species (ROS) generation. These ROS play a vital role to disrupt bacterial cell membrane, proteins, or nucleic acids. In this review, we compared the antimicrobial activities of different doped-IONPs, elucidated their mechanism(s), and put forth opinions for improved biocompatibility.

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Comparative studies on the cytotoxic effects induced by iron oxide nanoparticles in cancerous and noncancerous human lung cells subjected to an alternating magnetic field

Ruzycka-Ayoush,

Sobczak,

Grudzinski

2024

Toxicology in Vitro

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Application of biocompatible and ultrastable superparamagnetic iron(iii) oxide nanoparticles doped with magnesium for efficient magnetic fluid hyperthermia in lung cancer cells

Abstract: Iron(iii) oxide nanoparticles doped with magnesium exposed to an alternating magnetic field induced cytotoxic effects on lung cancer cells (A549).

Cited by 5 publications

References 78 publications

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Comparative studies on the cytotoxic effects induced by iron oxide nanoparticles in cancerous and noncancerous human lung cells subjected to an alternating magnetic field

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Application of biocompatible and ultrastable superparamagnetic iron(iii) oxide nanoparticles doped with magnesium for efficient magnetic fluid hyperthermia in lung cancer cells

Abstract: Iron(iii) oxide nanoparticles doped with magnesium exposed to an alternating magnetic field induced cytotoxic effects on lung cancer cells (A549).

Cited by 5 publications

References 78 publications

Fe3O4-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Fe3O4-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Comparative studies on the cytotoxic effects induced by iron oxide nanoparticles in cancerous and noncancerous human lung cells subjected to an alternating magnetic field

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Product

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Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer

Fe₃O₄-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer