Application of bacterial cellulose in skin and bone tissue engineering

Pang, Mujuan; Huang, Yong; Meng, Fanning; Zhuang, Yong; Liu, Hui; Du, Manling; Ma, Qianqian; Wang, Qi; Chen, Zhe; Chen, Lianyu; Cai, Tiange; Cai, Yu-Dong

doi:10.1016/j.eurpolymj.2019.109365

Cited by 163 publications

(109 citation statements)

References 134 publications

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“…This network architecture confers to BC tremendous possibilities to be used in various fields but especially in the medical field as a skin wound and burn cure, artificial skin, artificial blood vessels, dental implants, scaffolds for tissue engineering, and drug delivery systems, with the porous structure ensuring an efficient cell attachment and high capacity of exudate adsorption [ 8 ]. It is characterized by a good permeability and resistance to degradation, good mechanical properties, high purity and high water absorption capacity, remarkable biocompatibility, and high porosity [ 1 , 9 , 10 , 11 , 12 , 13 ]. Not only BC but also BC composites are considered promising wound dressing materials [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

et al. 2020

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The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings’ wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing’s property. The results confirmed the drugs’ presence in the bacterial-cellulose dressing’s structure as well as the antimicrobial efficiency against Staphylococcus aureus and Escherichia coli. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

et al. 2020

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“…BC is highly biocompatible due to its structural similarity to components of the extracellular matrix (e.g., collagen), and it undergoes complex interactions with biological tissues. The application of BC as scaffolds for tissue regeneration has been investigated for bone tissue, cartilage, muscles, skin tissue, and dental applications [ 11 , 12 , 13 , 14 ]. The influence of BC morphology on cell proliferation has been estimated in a number of research studies [ 1 , 15 ]; however, the limiting factor for the biomedical use of BC continues to be its low biodegradability [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose (Komagataeibacter rhaeticus) Biocomposites and Their Cytocompatibility

et al. 2020

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A series of novel polysaccharide-based biocomposites was obtained by impregnation of bacterial cellulose produced by Komagataeibacter rhaeticus (BC) with the solutions of negatively charged polysaccharides—hyaluronan (HA), sodium alginate (ALG), or κ-carrageenan (CAR)—and subsequently with positively charged chitosan (CS). The penetration of the polysaccharide solutions into the BC network and their interaction to form a polyelectrolyte complex changed the architecture of the BC network. The structure, morphology, and properties of the biocomposites depended on the type of impregnated anionic polysaccharides, and those polysaccharides in turn determined the nature of the interaction with CS. The porosity and swelling of the composites increased in the order: BC–ALG–CS > BC–HA–CS > BC–CAR–CS. The composites show higher biocompatibility with mesenchymal stem cells than the original BC sample, with the BC–ALG–CS composite showing the best characteristics.

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“…Several research projects have been carried out about the biocompatibility of both natural and synthetic electrospun polymers [149][150][151]. Among the first, chitosan [152], collagen [153], gelatin [154] or cellulose [155] have been widely explored in tissue engineering due to their bio-based origin, renewability, biocompatibility and biodegradability. Synthetic polymers such as poly (ε-caprolactone) (PCL) or PVA are among the most studied especially because they are easy to electrospun and present good mechanical properties [156,157].…”

Section: Advanced Smart Propertiesmentioning

confidence: 99%

Potential Applications of Magnesium-Based Polymeric Nanocomposites Obtained by Electrospinning Technique

et al. 2020

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In the last few decades, the development of new electrospun materials with different morphologies and advanced multifunctional properties are strongly consolidated. There are several reviews that describe the processing, use and characterization of electrospun nanocomposites, however, based on our knowledge, no review on electrospun nanocomposites reinforced with nanoparticles (NPs) based on magnesium, Mg-based NPs, are reported. Therefore, in the present review, we focus attention on the fabrication of these promising electrospun materials and their potential applications. Firstly, the electrospinning technique and its main processing window-parameters are described, as well as some post-processing methods used to obtain Mg-based materials. Then, the applications of Mg-based electrospun nanocomposites in different fields are pointed out, thus taking into account the current trend in developing inorganic-organic nanocomposites to gradually satisfy the challenges that the industry generates. Mg-based electrospun nanocomposites are becoming an attractive field of research for environmental remediation (waste-water cleaning and air filtration) as well as for novel technical textiles. However, the mayor application of Mg-based electrospun materials is in the biomedical field, as pointed out. Therefore, this review aims to clarify the tendency in using electrospinning technique and Mg-based nanoparticles to huge development at industrial level in the near future.

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Application of bacterial cellulose in skin and bone tissue engineering

Cited by 163 publications

References 134 publications

Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

Bacterial Cellulose (Komagataeibacter rhaeticus) Biocomposites and Their Cytocompatibility

Potential Applications of Magnesium-Based Polymeric Nanocomposites Obtained by Electrospinning Technique

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