Application of arterial spin labeling perfusion MRI to differentiate benign from malignant intracranial meningiomas

Qiao, Xin; Kim, Hyun Grace; Wang, Danny J.J.; Salamon, Noriko; Linetsky, Michael; Sepahdari, Ali R.; Ellingson, Benjamin M.; Pope, Whitney B.

doi:10.1016/j.ejrad.2017.10.005

Cited by 45 publications

(17 citation statements)

References 25 publications

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“…Our study verified the reliability of this simple classification. Other qualitative classifications of CBF maps have also been used in gliomas and meningiomas [11] , [31] , [32] .…”

Section: Discussionmentioning

confidence: 99%

Arterial Spin Labeling for Glioma Grade Discrimination: Correlations with IDH1 Genotype and 1p/19q Status

Wang

Xie

Liu

et al. 2019

Translational Oncology

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Since accurate grading of gliomas has important clinical value, the aim of this study is to evaluate the diagnostic efficacy of perfusion values derived from arterial spin labeling (ASL) to grade gliomas. In addition, the correlation between perfusion and isocitrate dehydrogenase 1 (IDH1) genotypes and chromosome arms 1p and 19q (1p/19q) status of gliomas was assessed. A total of 52 cases of supratentorial gliomas in adults who received ASL imaging were enrolled in this retrospective study. The cerebral blood flow (CBF) images derived from ASL and anatomical maps were normalized to the Montreal Neurological Institute coordinate system and matched. The mean CBF (meanCBF), the maximum CBF (maxCBF), and their relative values (rmeanCBF and rmaxCBF, respectively) were assessed in each case. The tumor grades, IDH1 genotypes, and 1p/19q status were diagnosed according to the 2016 WHO criteria. Receiver operating characteristic curves were performed to assess the efficacy of perfusion parameters for grading. Qualitatively, all gliomas were divided into high- and low-perfusion groups. The crosstabs chi-square test of independence was performed to calculate contingency coefficient (C) and Cramer V coefficient to assess the correlation between perfusion and IDH1 genotypes and 1p/19q status of gliomas. The rmaxCBF showed the best diagnostic efficacy; meanwhile, rmeanCBF had the best specificity for grade discrimination. In astrocytoma, there was a mild correlation between IDH1 genotypes and tumor perfusion with the Cramer's V coefficient of 0.378. There was no significant association between 1p/19q codeletion and perfusion in grade II and III gliomas.

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“…Our study verified the reliability of this simple classification. Other qualitative classifications of CBF maps have also been used in gliomas and meningiomas [11] , [31] , [32] .…”

Section: Discussionmentioning

confidence: 99%

Arterial Spin Labeling for Glioma Grade Discrimination: Correlations with IDH1 Genotype and 1p/19q Status

Wang

Xie

Liu

et al. 2019

Translational Oncology

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“…The ASL perfusion has shown increased rCBF in meningiomas, especially the angiomatous histological subtype. 30 In addition to correlation with vascularity, maximum rCBV has been shown to positively correlate with the Ki-67 proliferative index in meningiomas. 31 We believe that the perfusion imaging of intraparenchymal meningiomas is an important way to distinguish meningiomas from other tumors.…”

Section: Discussionmentioning

confidence: 99%

Giant Intraparenchymal Meningioma in a Female Child: Case Report and Literature Review

Guo¹,

Liang²,

Wang³

et al. 2021

CMAR

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Background Intraparenchymal meningiomas without dural attachment are extremely rare, especially in female children. To our knowledge, fibrous intraparenchymal meningioma located in the temporal lobe has never been reported in female children. The significance in the differential diagnosis of lesions in the temporal lobe should be emphasized. Case Presentation A 12-year-old girl was admitted to our hospital, complaining of recurrent generalized seizures for 2 months. Magnetic resonance imaging demonstrated a solid lesion located in the temporal lobe. The lesion underwent gross total resection. Histopathological examination indicated that the lesion was a fibrous meningioma. Postoperative rehabilitation was uneventful. Conclusion This case report presents an extremely unusual intraparenchymal fibrous meningioma of the temporal lobe with peritumoral edema and reviewed 21 intraparenchymal meningioma cases in children and to discuss the clinical presentation and treatment, differential diagnosis, and radiological features.

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“…However, TOF angiography does not allow for quantification of the supply of the individual vessels. ASL has also been used to perform meningioma grading and identify high grade aggressive forms [15]. Non selective ASL was used by Yoo et al to assess meningioma vascularity in comparison to DSA and found a high positive correlation between the two modalities [16].…”

Section: Discussionmentioning

confidence: 99%

Non-invasive qualitative and semiquantitative presurgical investigation of the feeding vasculature to intracranial meningiomas using superselective arterial spin labeling

et al. 2019

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Background Intracranial meningiomas may be amenable to presurgical embolization to reduce bleeding complications. Detailed information usually obtained by digital subtraction angiography (DSA) on the contribution of blood supply from internal and external carotid artery branches is required to prevent non-target embolization and is helpful for pre-surgical planning. Purpose To investigate the contribution of the feeding vasculature to intracranial meningiomas with superselective arterial spin labelling (sASL) as an alternative to DSA. Material and methods Consecutive patients presenting for meningioma resection were prospectively included. sASL perfusion images acquired on a clinical 3T MRI scanner were independently rated by two readers. Contribution of the external carotid artery (ECA), internal carotid artery (ICA) and vertebral/basilar artery (VA/BA) was rated as none, <50% or >50%. Correlation of sASL was performed in two patients undergoing DSA. Results 32 patients (61 ± 13 years) harboring 42 meningiomas could be included. sASL was technically successful in all patients. 19 meningiomas had ICA dominant supply, 19 had ECA dominant supply. One meningioma had mixed supply and in three meningiomas a perfusion signal could not be detected. While exclusive unilateral ECA supply was common (n = 14) and exclusive unilateral ICA was rare (n = 4), mixed supply from multiple vessels (n = 20) was a frequent finding. Interrater agreement was substantial (κ = 0.73). Agreement with DSA was perfect within our predefined categories. Conclusion sASL is able to identify the presence and extent of the feeding vasculature in intracranial meningiomas.

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Application of arterial spin labeling perfusion MRI to differentiate benign from malignant intracranial meningiomas

Cited by 45 publications

References 25 publications

Arterial Spin Labeling for Glioma Grade Discrimination: Correlations with IDH1 Genotype and 1p/19q Status

Arterial Spin Labeling for Glioma Grade Discrimination: Correlations with IDH1 Genotype and 1p/19q Status

Giant Intraparenchymal Meningioma in a Female Child: Case Report and Literature Review

Non-invasive qualitative and semiquantitative presurgical investigation of the feeding vasculature to intracranial meningiomas using superselective arterial spin labeling

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