Application of aptamer‐conjugated graphene oxide for specific enrichment of microcystin‐LR in Achatina fulica prior to matrix‐assisted laser desorption ionization mass spectrometry
Junli Feng,
Linpei Dong,
Haixing Wang
et al.
Abstract:Microcystin‐LR (MC‐LR), as a hepatotoxin, can cause liver swelling, hepatitis, and even liver cancer. In this study, MC‐LR aptamer (Apt‐3) modified graphene oxide (GO) was designed to enrich MC‐LR in white jade snail (Achatina fulica) and pond water, followed by matrix‐assisted laser desorption ionization mass spectrometry (MALDI‐MS) analysis. Results indicated that the Apt‐3/PEG/GO nanocomposites were highly specific to MC‐LR, and the detection limit of MALDI‐MS was 0.50 ng/mL. Moreover, the MC‐LR can be rele… Show more
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