Application of an electronic nose in the diagnosis of head and neck cancer

Leunis, Nicoline; Boumans, Marie-Louise; Kremer, Bernd; Din, Sinh; Stobberingh, Ellen E.; Kessels, Alfons G.H.; Kross, Kenneth W.

doi:10.1002/lary.24463

Cited by 78 publications

(103 citation statements)

References 36 publications

(52 reference statements)

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“…When coupled with multiple lines of recent data showing that exhaled H 2 S and urinary H 2 S is increased in cancer patients (as discussed earlier), it may possible that dogs sense cancer patients by detecting H 2 S. However, we believe that dogs detect a complex ''signature'' of various volatile molecules (including H 2 S). Such volatile signatures may be useful for the future detection of cancer, either by dogs or by various ''artificial nose'' systems currently under development (21,70).…”

Section: H 2 S Donation Versus H 2 S Biosynthesis Inhibition In Cancermentioning

confidence: 99%

The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer

Hellmich

Coletta

Chao

et al. 2015

Antioxidants & Redox Signaling

202

186

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Significance: Cancer represents a major socioeconomic problem; there is a significant need for novel therapeutic approaches targeting tumor-specific pathways. Recent Advances: In colorectal and ovarian cancers, an increase in the intratumor production of hydrogen sulfide (H 2 S) from cystathionine b-synthase (CBS) plays an important role in promoting the cellular bioenergetics, proliferation, and migration of cancer cells. It also stimulates peritumor angiogenesis inhibition or genetic silencing of CBS exerts antitumor effects both in vitro and in vivo, and potentiates the antitumor efficacy of anticancer therapeutics. Critical Issues: Recently published studies are reviewed, implicating CBS overexpression and H 2 S overproduction in tumor cells as a tumorgrowth promoting ''bioenergetic fuel'' and ''survival factor,'' followed by an overview of the experimental evidence demonstrating the anticancer effect of CBS inhibition. Next, the current state of the art of pharmacological CBS inhibitors is reviewed, with special reference to the complex pharmacological actions of aminooxyacetic acid. Finally, new experimental evidence is presented to reconcile a controversy in the literature regarding the effects of H 2 S donor on cancer cell proliferation and survival. Future Directions: From a basic science standpoint, future directions in the field include the delineation of the molecular mechanism of CBS upregulation of cancer cells and the delineation of the interactions of H 2 S with other intracellular pathways of cancer cell metabolism and proliferation. From the translational science standpoint, future directions include the translation of the recently emerging roles of H 2 S in cancer into human diagnostic and therapeutic approaches. Antioxid. Redox Signal. 22,

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Section: H 2 S Donation Versus H 2 S Biosynthesis Inhibition In Cancermentioning

confidence: 99%

The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer

Hellmich

Coletta

Chao

et al. 2015

Antioxidants & Redox Signaling

202

186

View full text Add to dashboard Cite

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“…However, they did not attempt quantification, and their study group comprised only 11 laryngeal carcinoma patients and 10 healthy controls (García et al , 2014). Leunis et al (2013) have chosen the alternative approach and have attempted identifying the breath-print of HNSCC from exhaled breath samples, using a commercial sensor array and statistical pattern analysis software. They could distinguish HNSCC patients from a control group of patients having unspecified benign conditions with 90% sensitivity and 80% specificity.…”

mentioning

confidence: 99%

Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study

et al. 2014

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Background:Squamous cell carcinoma of the head and neck (HNSCC) are wide-spread cancers that often lead to disfigurement and loss of important functions such as speech and ingestion. To date, HNSCC has no adequate method for early detection and screening.Methods:Exhaled breath samples were collected from 87 volunteers; 62 well-defined breath samples from 22 HNSCC patients (larynx and pharynx), 21 patients with benign tumours (larynx and pharynx) and 19 healthy controls were analysed in a dual approach: (i) chemical analysis using gas chromatography/mass spectrometry (GC–MS) and (ii) breath-print analysis using an array of nanomaterial-based sensors, combined with a statistical algorithm.Results:Gas chromatography/mass spectrometry identified ethanol, 2-propenenitrile and undecane as potential markers for HNSCC and/or benign tumours of the head and neck. The sensor-array-based breath-prints could clearly distinguish HNSCC both from benign tumours and from healthy states. Within the HNSCC group, patients could be classified according to tumour site and stage.Conclusions:We have demonstrated the feasibility of a breath test for a specific, clinically interesting application: distinguishing HNSCC from tumour-free or benign tumour states, as well as for staging and locating HNSCC. The sensor array used here could form the basis for the development of an urgently needed non-invasive, cost-effective, fast and reliable point-of-care diagnostic/screening tool for HNSCC.

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“…Other studies described possible volatile biomarkers in exhaled breath and the ability of electronic noses to recognize exhaled breath of patients suffering from malignant conditions in systems not involving the lungs and the respiratory system, such as breast, colon, prostate, and gastric cancer . Moreover, several studies analyzed the exhaled breath of patients with head and neck SCC as we did here . Using either electronic noses and GCMS, or electronic noses alone, these studies successfully generated differential diagnosis in advanced‐stage head and neck SCC (stage III/IV).…”

Section: Discussionmentioning

confidence: 88%

“…Several recent studies analyzed the exhaled breath of head and neck squamous cell carcinoma (SCC) patients and the capability of electronic noses to identify them . Most of these studies used profiling of the VOC fingerprint in the exhaled breath, and some suggested that specific compounds in the exhaled breath are possible volatile biomarkers for head and neck SCC .…”

Section: Introductionmentioning

confidence: 99%