Application of aluminum phthalocyanine nanoparticles for fluorescent diagnostics in dentistry and skin autotransplantology

Abstract

This paper deals with the possibility of application of aluminum phthalocyanine (AlPc) nanoparticles in clinical practice. AlPc fluoresces in the molecular form but in the form of nanoparticles it does not. Separation of molecules from an AlPc nanoparticle and therefore the appearance of fluorescence occurs under the effect of a number of biochemo‐physical factors. Owing to this feature the application of AlPc nanoparticles followed by the measurement of fluorescence spectra is proposed as a diagnostics method. It was shown that after AlPc nanoparticle application on a tooth surface the fluorescence intensity in the enamel microdamage area is 2–3 times higher than that in the normal enamel area. The appearance of fluorescence after application of AlPc nanoparticles on skin autografts testifies to the presence of inflammation. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

Influence of photoactivated tetra sulphonatophenyl porphyrin and TiO2nanowhiskers on rheumatoid arthritis infected bone marrow stem cell proliferation in vitro and oxidative stress biomarkers in vivo

“…38 Similarly, aluminum-phthalocyanine mediated PDT has also been associated with growth promoting effect on osteoblast cells. 39 The role of PDT is of interest in cures of autoimmune diseases especially RA. 40 In previous studies we reported a new therapeutic effect of photoactivated TSPP-TiO 2 nanocomposites on RA.…”

Diagnóstico Fotodinâmico: Princípios E Aplicações

“…O diagnóstico fotodinâmico também pode ser utilizado com sucesso para a classificação de risco da rejeição de enxertos de pele, por meio do monitoramento dos espectros de fluorescência de monômeros como o cloro alumino ftalocianina (ALPC) (VASILCHENKO et al, 2010). O ALPC é um fotossensibilizador que fluoresce na forma molecular, mas sob a forma de nanopartículas isso não acontece, dessa forma, utiliza-se nanopartículas hidrofóbicas como carreadoras do ALPC para o interior de macrófagos e neutrófilos.…”

Theranostic Properties of Crystalline Aluminum Phthalocyanine Nanoparticles as a Photosensitizer

“…We have previously discovered the effect of changes in the absorption and fluorescence spectra, the dynamics of interaction with laser radiation (photobleaching), and the fluorescence lifetime of self-aggregated AlPcCl nanoparticles upon changes in colloid pH, capture by immune cells (monocytes [ 35 ] and macrophages [ 36 ]), interaction with bacteria [ 37 , 38 ], and ingress of these particles into inflamed biological tissue [ 35 , 39 ]. We suggest that registration and characterization of changes in the spectral properties of AlPc NPs accumulated by malignant or tumor-associated cells can make it possible to assess the direction of the tumor process.…”