Application of additively manufactured 3D scaffolds for bone cancer treatment: a review

Hou, Yanhao; Wang, Weiguang; Bartolo, Paulo Jorge Da Silva

doi:10.1007/s42242-022-00182-7

Cited by 18 publications

(15 citation statements)

References 157 publications

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“…However, this treatment also affects healthy tissues and organs. [506] Most strikingly, AM of SRPs can be used to print personalized drug-loaded systems with precise control for localized cancer treatment. [507][508][509] 3D printing is useful, especially for the treatment of local tumor residuals, Bending and folding Soft millirobots [426] and enhances the efficiency of drug administration and minimizes the distribution and side effects of drugs in other parts of the body.…”

Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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“…Additionally, in-depth mechanism studies on how the material regulates genes and growth factors, as well as the safety of clinical applications, still require further investigation . Nevertheless, they showed great potential to replace the current clinically utilized natural bone grafts and further enhance bone regeneration efficiency. ,, To realize the expected outcome, the scaffolds must meet different requirements, including adequate mechanical support close to the native bone environment, biodegradability that matches the new bone regeneration rate, and the capability to stimulate vascularization, osteogenesis, and osteointegration, ultimately leading to rapid healing of bone tissue. , …”

Section: Introductionmentioning

confidence: 99%

3D-Printed Graphene and Graphene Quantum Dot-Reinforced Polycaprolactone Scaffolds for Bone-Tissue Engineering

Meng,

Hou,

Kurniawan

et al. 2024

ACS Appl. Nano Mater.

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The regeneration of large-scale bone loss due to accidents, trauma, diseases, or tumor resection is still a critical clinical challenge. With the development of additive manufacturing technology and advanced biomaterials, 3D-printed biocompatible synthetic polymer scaffolds have been widely studied for their key roles in supporting bone tissue regeneration. Scaffold aims to provide mechanical properties that match the host bone as well as biological activities that can effectively promote cell proliferation and differentiation, ultimately facilitating bone tissue regeneration. Due to its unique biocompatibility and biodegradability, polycaprolactone (PCL) becomes one of the dominant synthetic polymeric materials considered for scaffold fabrication. However, using PCL alone presents insufficient mechanical properties; thus, different functional fillers have been added to modulate both the mechanical and biological performance of fabricated scaffolds. Among all functional fillers, carbon nanomaterials, particularly graphene (G), have shown an emerging trend. Graphene quantum dots (GQD), a member of the graphene family, are regarded as an ideal next-generation functional filler for scaffold fabrication. It presents high solubility in water, controllable dose-dependent cytotoxicity similar to that of G, and unique biological properties benefiting from smaller sizes. Current research using GQD for tissue engineering applications is limited, and the systemic comparison between G and GQD at different concentrations is also missing. This study, for the first time, evaluates and compares the impact of incorporating G and GQD into PCL bone tissue engineering scaffolds from surface, thermal, mechanical, and biological perspectives. Results suggested that the addition of both materials under 5 wt % significantly improved both the mechanical and biological performance of PCL scaffolds. Under 3 wt %, PCL/GQD scaffolds presented better compressive strength while maintaining the same level of biological performance compared with PCL/G scaffolds, revealing the strong potential for future in vivo studies and bone tissue regeneration applications.

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“…32 Therefore, they are not suitable for the scalable patterning applications of metal oxide crystals. One strategy to address this challenge is to develop a hybrid method, [33][34][35] i.e., a combination of a top-down pattern transfer method and a bottom-up nanomaterial growth method, [36][37][38][39] that is capable of forming arbitrary patterns. J. Volk's group 40 successfully prepared vertically aligned hexagonal ZnO nanorod arrays by using polystyrene nanospheres as a mask for lithography.…”

Section: Introductionmentioning

confidence: 99%

Ordered growth of metal oxides in patterned multi-angle microstructures

Sun

Chen

et al. 2023

RSC Adv.

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Application of additively manufactured 3D scaffolds for bone cancer treatment: a review

Cited by 18 publications

References 157 publications

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

3D-Printed Graphene and Graphene Quantum Dot-Reinforced Polycaprolactone Scaffolds for Bone-Tissue Engineering

Ordered growth of metal oxides in patterned multi-angle microstructures

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