Application of acute phase proteins as indicators of retained placenta and their relation to energy metabolites in postcalving dairy cows

Fathi, Ezzatollah; Hamali, Hossein; Kaleibar, Mohamad Tolouei; Farahzadi, Raheleh

doi:10.1007/s00580-013-1853-y

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Therefore, the current study suggests proinflammatory cytokines and acute phase proteins as prognostic and diagnostic biomarkers of ketosis in this period. The use of acute phase proteins to monitor reproductive disorders (KRAKOWSKI and ZDZISINSKA, 2007) and ketosis (FATHI et al, 2013) in cows has already been documented. Disturbances in homeostasis in the transition period are the animal's reaction, known as the acute phase response (PINEIRO et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of ketosis in dairy cows at postparturient period: acute phase proteins and pro-inflammatory cytokines

El-Deeb

El-Bahr

2017

Vet. arhiv

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Section: Discussionmentioning

confidence: 99%

Biomarkers of ketosis in dairy cows at postparturient period: acute phase proteins and pro-inflammatory cytokines

El-Deeb

El-Bahr

2017

Vet. arhiv

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“…Haptoglobin is assumed to be elevated by tissue lesions occurring during birth and by the general proinflammatory situation for the time around calving [ 40 ]. It positively correlates with BHB, NEFA and TG [ 10 , 24 , 41 ]. The minor impact of the DPP4 inhibition regarding these variables may explain for the insignificant differences in Hp concentrations between groups.…”

Section: Discussionmentioning

confidence: 99%

Effects of Inhibiting Dipeptidyl Peptidase-4 (DPP4) in Cows with Subclinical Ketosis

et al. 2015

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The inhibition of dipeptidyl peptidase-4 (DPP4) via specific inhibitors is known to result in improved glucose tolerance and insulin sensitivity and decreased accumulation of hepatic fat in type II diabetic human patients. The metabolic situation of dairy cows can easily be compared to the status of human diabetes and non-alcoholic fatty liver. For both, insulin sensitivity is reduced, while hepatic fat accumulation increases, characterized by high levels of non-esterified fatty acids (NEFA) and ketone bodies.Therefore, in the present study, a DPP4 inhibitor was employed (BI 14332) for the first time in cows. In a first investigation BI 14332 treatment (intravenous injection at dosages of up to 3 mg/kg body weight) was well tolerated in healthy lactating pluriparous cows (n = 6) with a significant inhibition of DPP4 in plasma and liver. Further testing included primi- and pluriparous lactating cows suffering from subclinical ketosis (β-hydroxybutyrate concentrations in serum > 1.2 mM; n = 12). The intension was to offer effects of DPP4 inhibition during comprehensive lipomobilisation and hepatosteatosis. The cows of subclinical ketosis were evenly allocated to either the treatment group (daily injections, 0.3 mg BI 14332/kg body weight, 7 days) or the control group. Under condition of subclinical ketosis, the impact of DPP4 inhibition via BI 14332 was less, as in particular β-hydroxybutyrate and the hepatic lipid content remained unaffected, but NEFA and triglyceride concentrations were decreased after treatment. Owing to lower NEFA, the revised quantitative insulin sensitivity check index (surrogate marker for insulin sensitivity) increased. Therefore, a positive influence on energy metabolism might be quite possible. Minor impacts on immune-modulating variables were limited to the lymphocyte CD4+/CD8+ ratio for which a trend to decreased values in treated versus control animals was noted. In sum, the DPP4 inhibition in cows did not affect glycaemic control like it is shown in humans, but was able to impact hyperlipemia, as NEFA and TG decreased.

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“…Blood samples were collected from the jugular vein of two groups at weeks 1, 2 and 3 postpartum to determine hematological indices of PCV, Hb, WBCs, Neu, Band, Lym, RBCs, and PLT. Recently, some other parameters like APPs have been used following calving as an indicator of pending clinical metritis, ketosis and RP [1,[4][5][6][7][8][9]. The stages of diseases can be better evaluated by monitoring more than one analytic.…”

Section: Discussionmentioning

confidence: 99%

Towards to Changes in Blood Indices as Early Diagnosis of Retained Placenta

Fathi¹,

Hamali²

2018

Madridge J Immunol

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This study aims to examine hematological parameters for early diagnosis of retained placenta (RP) during three stages of postpartum periods in dairy cattle. For this purpose, thirty post calving dairy cows with RP (group I) and healthy (group II) were selected (n=15 each). The cows were placed into 3 stages of period, from 1 to 3 weeks after parturition. Then, blood samples were collected from two groups. No significant differences were observed in hematological indices between two groups of cattle. The results showed that RP does not cause to significant changes in some hematological parameters as well as total protein and albumin (Alb) when compared to the healthy cows (p<0.05). Also, significant increases in the concentration of fibrinogen (Fb) was observed in diseased cows during 1 to 2 weeks when compared to the healthy (p<0.05). Our results indicated, in spite of hematological parameter, some serum indices including Fib could be successfully applied as indicators for RP in post calving dairy cattle. Therefore, blood indices cannot be used for early diagnosis of RP in dairy cattle.

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Application of acute phase proteins as indicators of retained placenta and their relation to energy metabolites in postcalving dairy cows

Cited by 4 publications

References 26 publications

Biomarkers of ketosis in dairy cows at postparturient period: acute phase proteins and pro-inflammatory cytokines

Biomarkers of ketosis in dairy cows at postparturient period: acute phase proteins and pro-inflammatory cytokines

Effects of Inhibiting Dipeptidyl Peptidase-4 (DPP4) in Cows with Subclinical Ketosis

Towards to Changes in Blood Indices as Early Diagnosis of Retained Placenta

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