Autocorrelation coefficients, multiple determination coefficients, and single-vector uniqueness test are Investigated as predictors of the number of major electroactive components In a matrix resulting from coeluting components In high-performance liquid chromatography using a swept-potentlal electrochemical detection system. The estimate profiles of the pure components (chromatograms, voltammograms) are obtained by Iterative target test factor analysis and then refined by the least-squares method. The effects of mobile phase flow rate on the Instrument response are also Investigated In order to quantitate the Individual components In the matrix. All three predictors mentioned above complement one another satisfactorily, while the single-vector uniqueness test proves to be more powerful In heavily overlapped responses.