Application of a swept-potential electrochemical detector in the liquid-chroamtographic determination of nitrosamines

Thomas, Michael B.; Msimanga, Huggins Z.; Sturrock, Peter E.

doi:10.1016/s0003-2670(00)84387-1

Cited by 18 publications

(5 citation statements)

References 16 publications

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“…Of the nitrophenols studied previously in this laboratory (2), a mixture of 2,3-dinitrophenol, p-nitrophenol, and m-nitrophenol did not separate well enough to allow their quantitation. Also, of the nitrosoamines studied (20), N-nitroso-iV-methylanaline, N-nitroso-di-lV-propylamine, and N-nitroso-lV-ethylbutylamine did not separate adequately. These compounds were used for this study.…”

Section: Methodsmentioning

confidence: 81%

Application of factor analysis on high-performance liquid chromatography data using a swept-potential electrochemical detection system

Msimanga¹,

Sturrock²

1990

Anal. Chem.

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Autocorrelation coefficients, multiple determination coefficients, and single-vector uniqueness test are Investigated as predictors of the number of major electroactive components In a matrix resulting from coeluting components In high-performance liquid chromatography using a swept-potentlal electrochemical detection system. The estimate profiles of the pure components (chromatograms, voltammograms) are obtained by Iterative target test factor analysis and then refined by the least-squares method. The effects of mobile phase flow rate on the Instrument response are also Investigated In order to quantitate the Individual components In the matrix. All three predictors mentioned above complement one another satisfactorily, while the single-vector uniqueness test proves to be more powerful In heavily overlapped responses.

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Section: Methodsmentioning

confidence: 81%

Application of factor analysis on high-performance liquid chromatography data using a swept-potential electrochemical detection system

Msimanga¹,

Sturrock²

1990

Anal. Chem.

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“…A rapid scan voltammetric detector for flowing solutions was first reported by Wang et al for use in the analysis of discrete samples, flowing streams, and chromatographic effluents (2). Scanning voltammetric detection coupled to high-performance liquid chromatography (HPLC) provides an additional dimension of resolution along the potential axis which helps to resolve some chromatographically overlapped components (3)(4)(5)(6)(7)(8). In flow injection analysis (FIA), which usually does not employ a separation step, the extra resolution of voltammetry aids selectivity, and peak potential data provide qualitative in- formation for component identification (9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

Automated segmented flow electrochemical analyzer

Jayaweera¹,

Ramaley²

1989

Anal. Chem.

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“…Several voltammetric detection approaches have been reported for liquid chromatography. − The main disadvantage of voltammetric detection is the significantly poorer detection limits which can be achieved relative to those possible with amperometric detection. The poorer detection limits are a result of greater noise arising from the background currents associated with scanning the potential.…”

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confidence: 99%

Voltammetric Detection for Capillary Electrophoresis

et al. 1997

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Several approaches to implementing amperometric detection for capillary electrophoresis have been reported. This report describes the development of a voltammetric detector for CE. The detector is designed to minimize distortion of the voltammetry due to ohmic potential drop. This was accomplished by using a cast Nafion detection cell at the end of the separation capillary. The cast Nafion detection cell provided a low-dead-volume, low-resistance cell that minimized ohmic potential drop and peak band broadening. The ability to detect the current due to oxidation of analytes superimposed on a large background current was also improved. A dynamic background subtraction scheme was used in which a second working electrode, positioned in the electrochemical cell but outside of the detection cell, was used to compensate for the background current in real time. The output of the compensating working electrode was subtracted from the output of the detecting working electrode prior to analog-to-digital conversion. Postexperimental digital background subtraction was also implemented. This approach provided optimal elimination of the background current with maximal detection of the analytical signal. The voltammetric detector developed produced high-quality voltammetric response of analytes with injected concentrations as low as 0.20 microM. The system was evaluated by obtaining CE voltammograms of a mixture of eight test phenolic acids.

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Application of a swept-potential electrochemical detector in the liquid-chroamtographic determination of nitrosamines

Cited by 18 publications

References 16 publications

Application of factor analysis on high-performance liquid chromatography data using a swept-potential electrochemical detection system

Application of factor analysis on high-performance liquid chromatography data using a swept-potential electrochemical detection system

Automated segmented flow electrochemical analyzer

Voltammetric Detection for Capillary Electrophoresis

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