Abstract:Manufacturing of cell therapy products requires sufficient understanding of the cell culture variables and associated mechanisms for adequate control and risk analysis. The aim of this study was to apply an unstructured ordinary differential equation-based model for prediction of T-cell bioprocess outcomes as a function of process input parameters.A series of models were developed to represent the growth of T-cells as a function of time, culture volumes, cell densities, and glucose concentration using data fro… Show more
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