Application of a public health strategy to large-scale point-of-care screening for sickle cell disease in rural sub-Saharan Africa

Chunda‐Liyoka, Catherine; Kumar, Anagha; Sambo, Pauline; Lubinda, Felicity; Nchimba, L.; Humpton, T.; Okuku, Pauline; Miyanda, C.; I, Judy Im; Maguire, Kerry; Whitesides, George M.; Stossel, Thomas P.

doi:10.1182/bloodadvances.2018gs112321

Cited by 6 publications

(2 citation statements)

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“…p is the estimated prevalence of sickle cell traits or sickle cell disease in newborn babies. The calculated sample size was 201 participants based on a study in Zambia [41] in which the prevalence (p) of the sickle cell trait was 15.5%. The precision for the sample size was 5%.…”

Section: Sample Size Determinationmentioning

confidence: 99%

Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia

Mano,

Kuona,

Misihairabgwi

2024

BMC Pediatr

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Background Sickle cell disease (SCD), a noncommunicable disease, has the greatest burden in sub-Saharan Africa. The majority of children (50–90%) with SCD die before their 5th birthday, with approximately 150,000–300,000 annual SCD child deaths in Africa. In developed countries, newborn screening (NBS) has been shown to improve the survival of children with sickle cell disease, with under5 childhood mortality reduced tenfold due to interventions performed before the development of complications. Point –of-care tests have been developed for resource limited settings to expand NBS. The aim of this study was to determine the birth prevalence of sickle cell disease in Namibia using the HemoTypeSC™ point-of-care test. Methods A cross-sectional descriptive study was carried out at Rundu Intermediate Hospital in the Kavango East Region. Two hundred and two (202) well newborns within 72 h of birth were recruited for the study from 22 February to the 23th March 2023. Descriptive statistics were used to compute the haemoglobin types of the study participants. Results The majority of the participants (n = 105, 52%) were females, and (n = 97,48%) were males. The median age of the participants was 23 h (Q1, Q3; 11; 33),) with an age range of 2–98 h. Sickle cell trait was present in 9.4% of the screened newborns, no homozygous disease was detected, and 90.6% had Hb AA. Conclusions This study is the first to measure HbS gene carriage at birth using HemotypeSC point-of-care testing in Namibia. There was a moderate prevalence of sickle cell traits but no SCD. This baseline study may provide the foundation for larger epidemiological surveys to map HbS gene carriage in Namibia to provide evidence for policy makers to fashion appropriate SCD newborn screening services.

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Section: Sample Size Determinationmentioning

confidence: 99%

Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia

Mano,

Kuona,

Misihairabgwi

2024

BMC Pediatr

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“…In Zambia, a multidisciplinary network in a rural area has demonstrated the feasibility of using dental services to facilitate large-scale SCD point-of-care screening. Scaling up of dental services and other public health approaches, including the expanded program for immunization, has great potential for scaling up screening for SCD, including newborn screening in low-resource settings (Chunda-Liyoka et al, 2018 ).…”

Section: Select Single-country Studiesmentioning

confidence: 99%

The Sickle Cell Disease Ontology: Enabling Collaborative Research and Co-Designing of New Planetary Health Applications

Nembaware

Mazandu

Hotchkiss

et al. 2020

OMICS: A Journal of Integrative Biology

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Sickle cell disease (SCD) is one of the most common blood disorders impacting planetary health. Over 300,000 newborns are diagnosed with SCD each year globally, with an increasing trend. The sickle cell disease ontology (SCDO) is the most comprehensive multidisciplinary SCD knowledge portal. The SCDO was collaboratively developed by the SCDO working group, which includes experts in SCD and data standards from across the globe. This expert review presents highlights and lessons learned from the fourth SCDO workshop that marked the beginning of applications toward planetary health impact, and with an eye to empower and cultivate multisite SCD collaborative research. The workshop was organized by the Sickle Africa Data Coordinating Center (SADaCC) and attended by 44 participants from 14 countries, with 2 participants connecting remotely. Notably, from the standpoint of democratizing and innovating scientific meeting design, an SCD patient advocate also presented at the workshop, giving a broader real-life perspective on patients' aspirations, needs,

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Emerging point-of-care technologies for sickle cell disease diagnostics

Ilyas

Simonson²,

Asghar

2020

Clinica Chimica Acta

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Application of a public health strategy to large-scale point-of-care screening for sickle cell disease in rural sub-Saharan Africa

Cited by 6 publications

References 1 publication

Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia

Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia

The Sickle Cell Disease Ontology: Enabling Collaborative Research and Co-Designing of New Planetary Health Applications

Emerging point-of-care technologies for sickle cell disease diagnostics

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