Application of a pressure servo system developed to study ventricular dynamics.

Janicki, J S; Reeves, Robert L.; Weber, Karl T.; Donald, Thomas C.; Walker, Alfred A.

doi:10.1152/jappl.1974.37.5.736

Cited by 21 publications

(3 citation statements)

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“…In a previously published study by another laboratory [18] using a preparation similar to ours, the contractility of isolated canine hearts supported by a blood oxygenator deteriorated with time at a rate of 8% per h. In a single timecontrol test, we observed the changes in contractility over time and found a similar rate of deterioration (7.6% per h).…”

Section: Methodssupporting

confidence: 78%

Effects of pentobarbital on inotropic state of isolated canine left ventricle

1993

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Although pentobarbital has been found to depress myocardial function, the magnitude of its direct effects on ventricular contraction at anesthetic concentrations has not been well quantified. The direct effects of pentobarbital on left ventricular function were measured by employing an isolated canine heart preparation with a blood oxygenator. Seven hearts were perfused with blood, dextran, and perfluorochemical artificial blood. Ventricular function was evaluated using the slope of the end-systolic pressure-volume relationship (Ees) and the maximal rate of pressure development (dP/dtmax) in ventricles contracting isovolumically in control, after a low dose (13 micrograms/ml), and after a high dose (48 micrograms/ml) of pentobarbital. These concentrations represent one-half and two times the typical value (25 micrograms/ml) found to produce anesthesia in canines (assessed by tail clamp or blink reflex). The low dose of pentobarbital did not produce clear-cut depression in contractile function. The high dose of pentobarbital produced significant reductions of Ees, and dP/dtmax: Ees decreased 29%, from a control of 4.30 +/- 0.84 to 3.05 +/- 0.49 mmHg/ml and dP/dtmax decreased 24%, from a control of 909 +/- 148 to 695 +/- 173 mmHg/s. Thus, the threshold for the direct depressant effect of pentobarbital on ventricular function falls within the range of half to double the typically-reported anesthetic concentrations.

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Section: Methodssupporting

confidence: 78%

Effects of pentobarbital on inotropic state of isolated canine left ventricle

1993

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“…In this respect, dog Langendorff preparations are more preferable for obtaining information about intrinsic cardiac mechanism. As opposed to Langendorff preparations of small mammals, dog Langendorff prepara tions can only be run by means of perfusing the coronary arterial bed with arterial blood (Hashimoto et al 1960;Janicki et al 1974;Suga and Sagawa 1974).…”

mentioning

confidence: 99%

“…The operation for the dog Langendorff preparation has commonly been done without any time of heart-anoxia, i.e, in the state of "beating heart" (Hashimoto et al 1960; Janicki et al 1974;Suga and Sagawa 1974), because any anoxia of the heart has been believed to be detrimental to its function (Weiner et al 1976; Hess et al 1979) and structure (Kloner et al 1983). The operation for this kind of preparations without any time of heart-anoxia is, however, complicated and needs much time and skill.…”

mentioning

confidence: 99%