Application of 7.0 T ultra-high-field MRI in evaluating the structure and function of the right ventricle of the heart in rats under a chronic hypoxic environment at high altitude

Sun, Yanqiu; Zhang, Chenhong; Tian, Dengfeng; Bai, Jing; Li, Yaodong; Yu, Xiaosheng; Yang, Jing; Wang, Xueling; Yan, Dong; Yang, Mingshi; Kang, Zhiqiang; Zhang, Qiang

doi:10.21037/atm-21-5078

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…With the advancement of software and hardware technology, 7.0T CMR will be widely used clinically in the future and will play a significant role in promoting functional, metabolic, and molecular imaging. [95,96] 2.9.2. The Emergence of New CMR Contrast Agents CMR has become an indispensable clinical diagnostic tool owing to its excellent resolution and functionality.…”

Section: Wide Application Of Ultrahigh Field Cmrmentioning

confidence: 99%

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Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction

Wang,

2023

Small Methods

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Acute myocardial infarction (AMI) is one of the primary causes of death worldwide, with a high incidence and mortality rate. Assessment of the infarcted and surviving myocardium, along with microvascular obstruction, is crucial for risk stratification, treatment, and prognosis in patients with AMI. Nonionizing radiation, excellent soft tissue contrast resolution, a large field of view, and multiplane imaging make cardiac magnetic resonance (CMR) a “one‐stop” method for assessing cardiac structure, function, perfusion, and metabolism. Hence, this imaging technology is considered the “gold standard” for evaluating myocardial function and viability in AMI. This review critically compares the advantages and disadvantages of CMR with other cardiac imaging technologies, and relates the imaging findings to the underlying pathophysiological processes in AMI. A more thorough understanding of CMR technology will clarify their advanced clinical diagnosis and prognostic assessment applications, and assess the future approaches and challenges of CMR in the setting of AMI.

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Section: Wide Application Of Ultrahigh Field Cmrmentioning

confidence: 99%

Section: Cardiac Magnetic Resonance Imaging Techniquesmentioning

confidence: 99%

Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction

Wang,

2023

Small Methods

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“…In a previous study from our group [ 15 ], we found that the right ventricular structure and function changed in rats exposed to high altitude hypobaric hypoxic environment after 12 weeks, manifested as right ventricular end-diastolic volume, right ventricular end-systolic volume, right ventricular stroke volume, Right ventricular diastolic myocardial mass, Right ventricular systolic myocardial mass, tricuspid valve end systole caliber, right ventricular end-systolic Long axis and right ventricular end-diastolic long-axis levels were elevated. Pathological changes such as focal vacuolar degeneration and a small amount of inflammatory cell infiltration were seen under the microscope of the right ventricle.…”

Section: Introductionmentioning

confidence: 99%

Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study

Sun,

Zhang,

et al. 2024

BMC Cardiovasc Disord

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Background Long-term exposure to a high altitude environment with low pressure and low oxygen could cause abnormalities in the structure and function of the heart. Myocardial strain is a sensitive indicator for assessing myocardial dysfunction, monitoring myocardial strain is of great significance for the early diagnosis and treatment of high altitude heart-related diseases. This study applies cardiac magnetic resonance tissue tracking technology (CMR-TT) to evaluate the changes in left ventricular myocardial function and structure in rats in high altitude environment. Methods 6-week-old male rats were randomized into plateau hypoxia rats (plateau group, n = 21) as the experimental group and plain rats (plain group, n = 10) as the control group. plateau group rats were transported from Chengdu (altitude: 360 m), a city in a plateau located in southwestern China, to the Qinghai-Tibet Plateau (altitude: 3850 m), Yushu, China, and then fed for 12 weeks there, while plain group rats were fed in Chengdu(altitude: 360 m), China. Using 7.0 T cardiac magnetic resonance (CMR) to evaluate the left ventricular ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV) and stroke volume (SV), as well as myocardial strain parameters including the peak global longitudinal (GLS), radial (GRS), and circumferential strain (GCS). The rats were euthanized and a myocardial biopsy was obtained after the magnetic resonance imaging scan. Results The plateau rats showed more lower left ventricular GLS and GRS (P < 0.05) than the plain rats. However, there was no statistically significant difference in left ventricular EDV, ESV, SV, EF and GCS compared to the plain rats (P > 0.05). Conclusions After 12 weeks of exposure to high altitude low-pressure hypoxia environment, the left ventricular global strain was partially decreased and myocardium is damaged, while the whole heart ejection fraction was still preserved, the myocardial strain was more sensitive than the ejection fraction in monitoring cardiac function.

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“…Since the pathophysiological mechanism of HADA occurs on the basis of high-altitude acclimatization, these events must be studied together rather than as isolated events. Our previous investigation ( 16 ) demonstrated that a high-altitude hypobaric hypoxia environment exerts different effects on the structure, function, and strain of the right ventricle of rat hearts. This current study used 7.0T CMR cinematography and CMR-TT technique to further investigate the recovery of right ventricular function after returning to a plain oxygen-enriched environment for a period of time.…”

Section: Introductionmentioning

confidence: 99%

7.0T cardiac magnetic resonance imaging of right ventricular function in rats with high-altitude deacclimatization

Sun¹,

Zhang²,

He³

et al. 2023

Ann Transl Med

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Background High-altitude deacclimatization syndrome (HADAS) is a severe public health issue. The study of the changes in right ventricular function caused by high-altitude deacclimatization (HADA) is of great significance for the prevention and treatment of HADAS. Methods Six-week-old, male Sprague Dawley (SD) rats were randomly divided into the plain, plateau and the HADA group. Rats in the plateau and plain group were exposed to altitudes of 3,850 and 360 m, respectively, for 12 weeks. Rats in HADA group were exposed to the plateau altitude of 3,850 m for 12 weeks and subsequently transported to the plain altitude of 360 m for 4 weeks. Right ventricular ejection fraction (RVEF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and myocardial strain parameters, including the global longitudinal strain (GLS), global radial strain (GRS), and global circumferential strain (GCS), were evaluated by 7.0T cardiac magnetic resonance (CMR). The levels of red blood cell (RBC), hemoglobin (HGB), and hematocrit (HCT) in the blood were measured, and hematoxylin-eosin (HE) staining was used to observe the pathological changes in the myocardium. Results In rats in the plateau group, the right ventricular fibrous space was slightly widened, and partial focal steatosis were observed. However, in the HADA group, only a few focal steatoses were found. Rats in the plateau group had elevated levels of RBC, HGB and HCT, increased right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV) and right ventricular stroke volume (RVSV), and decreased right ventricular global longitudinal strain (RVGLS), right ventricular global circumferential strain (RVGCS), and right ventricular global radial strain (RVGRS) compared to rats in the plain group (P<0.001). The RVEDV, RVGCS, and RVGRS in the HADA group basically returned to the plain state. Interestingly, the RVESV in the HADA group was higher, while the RVSV, RVEF, and RVGLS were lower than those in the other two groups. Conclusions After 12 weeks of exposure to high-altitude environment, there were some pathological changes and the whole contractile strain of the right ventricle was observed. Some pathological changes in the myocardial tissue and stroma recovered after returning to the plain for 4 weeks. However, the right ventricular systolic function and strain did not recover completely.

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Application of 7.0 T ultra-high-field MRI in evaluating the structure and function of the right ventricle of the heart in rats under a chronic hypoxic environment at high altitude

Cited by 6 publications

References 34 publications

Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction

Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction

Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study

7.0T cardiac magnetic resonance imaging of right ventricular function in rats with high-altitude deacclimatization

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