Application of 2,4-bis(halomethyl)quinoline: synthesis and biological activities of 2,4-bis(benzofuran-2-yl)- and 2,4-bis(aroxymethyl)quinolines

Recent Advances in Synthesis and Biological Assessment of Quinoline‐Oxygen Heterocycle Hybrids

“…A series of quinoline‐benzofuran hybrids have also been designed and synthesized by Li et al. [47] . In this protocol, 2,4‐(dihalomethyl)‐substituted quinoline‐3‐carboxylate 69 was reacted with salicylaldehydes 70 ( a – i ) for the synthesis of 2,4‐bis(benzofuran‐2‐yl)quinoline‐3‐carboxylic acid derivatives 71 ( a – i ).…”

An approach for the synthesis of 2-aryl-3-sulfonyl substituted quinolines through an electrochemical cascade annulation pathway

“…1 Moreover, their derivatives are extensively found in various fields, such as biocides, dyes, and rubbers. 2 As a consequence, the synthetic development of efficient protocols for the functionalized quinolines via de novo design is of great importance. Traditionally, the classic construction of quinoline scaffolds could be achieved through named reactions such as Skraup, Povarov, and Friedlander reactions, 3 since Skraup firstly reported the formation of quinolines by heating anilines with glycerol in the presence of concentrated H 2 SO 4 with an oxidant in 1880.…”