APPLICATION MEAN CENTERING RATIO SPECTRA METHOD FOR TERNARY MIXTURE OF DEXTROMETHORPHAN HBr, DOXYLAMINE SUCCINATE, AND PSEUDOEPHEDRINE HCl IN TABLET PREPARATIONS
RIDA EVALINA TARIGAN,
HENDRI FAISAL,
IMAN KRISTIAN LASE
et al.
Abstract:Objective: The aim of this research is to apply the mean Centering Ratio Spectra (MCRS) method for a ternary mixture of Dextromethorphan Hydrobromide (DE), Doxylamine Succinate (DO), and Pseudoephedrine Hydrochloride (PS) in tablet preparations.
Methods: The absorption spectra of DE (40-430 μg/ml), DO (20-430 μg/ml), and PS (230-630 μg/ml) were scanned in the 200-400 nm range. DE determination involved dividing DE spectra by PS (430 μg/ml) and mean-centered the ratio spectra. DO spectra were divided by DE (40 … Show more
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