Application and Robust H??control of PDC fuzzy Controller for Nonlinear Systems with External Disturbance

Chiang, Wei-Ling; Chen, Treng Wu; Liu, Ming Yi; Hsu, C.

doi:10.51400/2709-6998.2438

Cited by 17 publications

(2 citation statements)

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“…Hand hygiene was reported to be a critical factor for controlling the spread of infections among HCWs and patients in hospital care settings [ 6 , 10 , 11 ]. Although washing hands with soap and water are effective for keeping hand hygiene, alcohol-based hand sanitizers are commonly used for hand disinfection in hospital settings due to their broad-spectrum antimicrobial activity against bacteria, viruses, parasites, and fungi [ 12 , 13 ]. However, frequent administration of alcohol-based hand sanitizers has been reported to be associated with several side effects, such as redness and cracking of skin, with the possibility of infection, as well as developing microbial resistance and virus outbreaks [ 6 , 11 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Rhamnolipid Nano-Micelles Inhibit SARS-CoV-2 Infection and Have No Dermal or Eye Toxic Effects in Rabbits

et al. 2022

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Hand hygiene is considered to be the key factor in controlling and preventing infection, either in hospital care settings or in the community. Alcohol-based hand sanitizers are commonly used due to their rapid action and broad spectrum of microbicidal activity, offering protection against bacteria and viruses. However, their frequent administration during COVID-19 pandemic was associated with serious hazards, such as skin toxicity, including irritation, skin dermatitis, skin dryness or cracking, along with peeling redness or itching, with the higher possibility of getting infections. Thus, there is a need to find alternative and novel approaches for hand sanitation. In our previous publications, we reported that rhamnolipids nano-micelles had a comparable antibacterial activity to alcohol-based hand sanitizer and a lower cytotoxicity against human dermal fibroblast cells. In the current study, we investigated the antiviral activity of rhamnolipids nano-micelles against SARS-CoV-2. There was no cytotoxic effect on Vero cells noted at the tested concentrations of rhamnolipids nano-micelles. The rhamnolipids nano-micelles solution at 20, 78, and 312 µg/mL all demonstrated a significant (p < 0.05) decrease of virus infectivity compared to the virus only and the blank vehicle sample. In addition, an acute irritation test was performed on rabbits to further ascertain the biosafety of rhamnolipids nano-micelles. In the eye and skin irritation tests, no degree of irritation was recorded after topical application of rhamnolipids nano-micelles. In addition, histopathological, biomarker, and hematological analyses from animals treated with rhamnolipids nano-micelles were identical to those recorded for untreated animal. From the above, we can conclude that rhamnolipids nano-micelles are a good candidate to be used as a hand sanitizer instead of alcohol-based hand sanitizers. However, they must still be tested in the future among healthcare workers (HCW) in a health care setting to ascertain their antimicrobial efficacy and safety compared to alcohol-based hand sanitizers.

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Section: Introductionmentioning

confidence: 99%

Rhamnolipid Nano-Micelles Inhibit SARS-CoV-2 Infection and Have No Dermal or Eye Toxic Effects in Rabbits

et al. 2022

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“…Therefore, the Centers for Disease Control and Prevention and the World Health Organization stated that hand hygiene is the key action to control/prevent the spread of infections in healthcare settings and the community [ 4 ]. Washing hands with soap and water is the traditional strategy to maintain hand hygiene; however, in healthcare settings, alcohol-based hand sanitizers are considered the most effective hand sanitizer products due to their broad-spectrum antimicrobial activity and ability able to kill micro-organisms including bacteria, parasites, fungi, and viruses [ 8 , 9 ]. Frequent application of alcohol-based hand sanitizers, especially in the occasion of a pandemic (e.g., the COVID-19 pandemic), was associated with several challenges and concerns such as skin toxicity including irritation, skin dermatitis, skin dryness or cracking, and peeling, redness, or itching [ 10 ], which was associated with an increased risk of infection [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Antibacterial Activity and Safety of Zinc Oxide Nanoparticles versus a Commercial Alcohol-Based Hand-Sanitizer: Can Zinc Oxide Nanoparticles Be Useful for Hand Sanitation?

et al. 2022

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Hand hygiene is the key factor to control and prevent the spread of infections, for example, hospital-acquired infections (HAIs). People commonly use alcohol-based hand sanitizers to assure hand hygiene. However, frequent use of alcohol-based hand sanitizers in a pandemic situation (e.g., COVID-19) was associated with serious drawbacks such as skin toxicity including irritation, skin dermatitis, and skin dryness or cracking, along with peeling, redness, or itching with higher possibility of infection. This demands the development of alternative novel products that are effective as alcohol-based hand sanitizers but have no hazardous effects. Zinc oxide nanoparticles (ZnO-NPs) are known to have broad-spectrum antimicrobial activity, be compatible with the biological system and the environment, and have applicable and economic industrial-scale production. Thus, ZnO-NPs might be a good candidate for hand sanitation. To the best of our knowledge, the antibacterial activity of ZnO-NPs in comparison to alcohol-based hand sanitizers has not yet been studied. In the present work, a comparative study of the antibacterial activity of ZnO-NPs vs. Sterillium, a commercial alcohol-based hand sanitizer that is commonly used in Egyptian hospitals, was performed against common microorganisms known to cause HAIs in Egypt, including Acinetobacter baumannii, Klebsiella pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), and Staphylococcus aureus. The safety profiles of ZnO-NPs and Sterillium were also assessed. The obtained results demonstrated the superior antibacterial activity and safety of ZnO-NPs compared to Sterillium. Therefore, ZnO-NPs could be a promising candidate for hand sanitation in comparison to alcohol-based hand sanitizers; however, several studies related to long-term toxicity and stability of ZnO-NPs and investigations into their antimicrobial activity and safety in healthcare settings are still required in the future to ascertain their antimicrobial activity and safety.

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Multi-constrained Fuzzy Control for Perturbed T–S Fuzzy Singular Systems by Proportional-Plus-Derivative State Feedback Method

Chang

Lian

et al. 2021

Int. J. Fuzzy Syst.

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Application and Robust H??control of PDC fuzzy Controller for Nonlinear Systems with External Disturbance

Cited by 17 publications

References 0 publications

Rhamnolipid Nano-Micelles Inhibit SARS-CoV-2 Infection and Have No Dermal or Eye Toxic Effects in Rabbits

Rhamnolipid Nano-Micelles Inhibit SARS-CoV-2 Infection and Have No Dermal or Eye Toxic Effects in Rabbits

Investigating the Antibacterial Activity and Safety of Zinc Oxide Nanoparticles versus a Commercial Alcohol-Based Hand-Sanitizer: Can Zinc Oxide Nanoparticles Be Useful for Hand Sanitation?

Multi-constrained Fuzzy Control for Perturbed T–S Fuzzy Singular Systems by Proportional-Plus-Derivative State Feedback Method

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