Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review

Mahmoudi, Hassan; Hossainpour, Hadi

doi:10.4103/sjg.sjg_131_22

Cited by 11 publications

(7 citation statements)

References 62 publications

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“…Since then, FMT has gained recognition as a therapy for a wide range of gastrointestinal as well as non-gastrointestinal conditions. However, there remains limited understanding of its mechanism of action and potential long-term side effects (258). The probable therapeutic effects of FMT have also been demonstrated in a number of animal models involving people with severe multiple sclerosis, autism, multidrugresistant (MDR) infections, and multiple organ failure in seriously confined people (259-261).…”

Section: Fecal Microbiota Transplantation As a Prevention Strategymentioning

confidence: 99%

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

Luqman,

Hassan,

Ullah

et al. 2024

Front. Immunol.

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The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such a microbiome is essential for sustaining host equilibrium, and its impact on human health can be altered by a variety of factors such as external variables, social behavior, age, nutrition, and genetics. Gut microbes’ imbalances are related to a variety of chronic diseases including cancer, obesity, and digestive disorders. Globally, recent findings show that intestinal microbes have a significant role in the formation of cardiovascular disease (CVD), which is still the primary cause of fatalities. Atherosclerosis, hypertension, diabetes, inflammation, and some inherited variables are all cardiovascular risk variables. However, studies found correlations between metabolism, intestinal flora, and dietary intake. Variations in the diversity of gut microbes and changes in their activity are thought to influence CVD etiology. Furthermore, the gut microbiota acts as an endocrine organ, producing bioactive metabolites such as TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), and bile acids, which have a substantial impact on host wellness and disease by multiple mechanisms. The purpose of this overview is to compile current evidence highlighting the intricate links between gut microbiota, metabolites, and the development of CVD. It focuses on how intestinal dysbiosis promotes CVD risk factors such as heart failure, hypertension, and atherosclerosis. This review explores the normal physiology of intestinal microbes and potential techniques for targeting gut bacteria for CVD treatment using various microbial metabolites. It also examines the significance of gut bacteria in disease treatment, including supplements, prebiotics, probiotics, antibiotic therapies, and fecal transplantation, which is an innovative approach to the management of CVD. As a result, gut bacteria and metabolic pathways become increasingly attractive as potential targets for CVD intervention.

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Section: Fecal Microbiota Transplantation As a Prevention Strategymentioning

confidence: 99%

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

Luqman,

Hassan,

Ullah

et al. 2024

Front. Immunol.

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“…Fecal bacteria transplantation (FMT) refers to the prevention and treatment of parenteral diseases by implanting beneficial bacteria such as probiotics in healthy people into the intestines of patients to reshape new flora ( Mahmoudi and Hossainpour, 2023 ). FMT therapy for CDI has promising clinical applications ( Khoruts et al., 2010 ).…”

Section: Intervention Of Gut Microbiota Aids In the Treatment Of Gdmmentioning

confidence: 99%

Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review

Ma,

Wang,

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionGestational diabetes mellitus (GDM) is a form of gestational diabetes mellitus characterized by insulin resistance and abnormal function of pancreatic beta cells. In recent years, genomic association studies have revealed risk and susceptibility genes associated with genetic susceptibility to GDM. However, genetic predisposition cannot explain the rising global incidence of GDM, which may be related to the increased influence of environmental factors, especially the gut microbiome. Studies have shown that gut microbiota is closely related to the occurrence and development of GDM. This paper reviews the relationship between gut microbiota and the pathological mechanism of GDM, in order to better understand the role of gut microbiota in GDM, and to provide a theoretical basis for clinical application of gut microbiota in the treatment of related diseases.MethodsThe current research results on the interaction between GDM and gut microbiota were collected and analyzed through literature review. Keywords such as "GDM", "gut microbiota" and "insulin resistance" were used for literature search, and the methodology, findings and potential impact on the pathophysiology of GDM were systematically evaluated.ResultsIt was found that the composition and diversity of gut microbiota were significantly associated with the occurrence and development of GDM. Specifically, the abundance of certain gut bacteria is associated with an increased risk of GDM, while other changes in the microbiome may be associated with improved insulin sensitivity. In addition, alterations in the gut microbiota may affect blood glucose control through a variety of mechanisms, including the production of short-chain fatty acids, activation of inflammatory pathways, and metabolism of the B vitamin group.DiscussionThe results of this paper highlight the importance of gut microbiota in the pathogenesis of GDM. The regulation of the gut microbiota may provide new directions for the treatment of GDM, including improving insulin sensitivity and blood sugar control through the use of probiotics and prebiotics. However, more research is needed to confirm the generality and exact mechanisms of these findings and to explore potential clinical applications of the gut microbiota in the management of gestational diabetes. In addition, future studies should consider the interaction between environmental and genetic factors and how together they affect the risk of GDM.

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“…Since the gut microbiota is known to be the causally responsible for the development and deterioration of metabolic syndromes, it may at least partially regulate the occurrence of metabolic imbalance-induced fatigue [ 113 , 123 ]. The elevation of bacteria producing L-lactic acid in the gut microbiome will also lead to the exacerbation of exercise-induced fatigue [ 124 ].…”

Section: Polysaccharides Ameliorate Fatigue Via the Gut-muscle Axismentioning

confidence: 99%

Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Zhou,

Chu,

Luo

et al. 2023

Foods

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Due to today’s fast-paced lifestyle, most people are in a state of sub-health and face “unexplained fatigue”, which can seriously affect their health, work efficiency, and quality of life. Fatigue is also a common symptom of several serious diseases such as Parkinson’s, Alzheimer’s, cancer, etc. However, the contributing mechanisms are not clear, and there are currently no official recommendations for the treatment of fatigue. Some dietary polysaccharides are often used as health care supplements; these have been reported to have specific anti-fatigue effects, with minor side effects and rich pharmacological activities. Dietary polysaccharides can be activated during food processing or during gastrointestinal transit, exerting unique effects. This review aims to comprehensively summarize and evaluate the latest advances in the biological processes of exercise-induced fatigue, to understand dietary polysaccharides and their possible molecular mechanisms in alleviating exercise-induced fatigue, and to systematically elaborate the roles of gut microbiota and the gut-muscle axis in this process. From the perspective of the gut-muscle axis, investigating the relationship between polysaccharides and fatigue will enhance our understanding of fatigue and may lead to a significant breakthrough regarding the molecular mechanism of fatigue. This paper will provide new perspectives for further research into the use of polysaccharides in food science and food nutrition, which could help develop potential anti-fatigue agents and open up novel therapies for sub-health conditions.

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Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review

Cited by 11 publications

References 62 publications

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review

Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

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