Application and Characterization of in Situ Gel

Kurniawansyah, Insan Sunan; Sopyan, Iyan; Wathoni, Nasrul; Fillah, Dasty Latifa; Praditya, Rahadianti Umi

doi:10.22159/ijap.2018v10i6.28767

Cited by 18 publications

(20 citation statements)

References 20 publications

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“…Each sample was observed under the microscope (magnification of ×40). The samples were taken from 3 parts of the preparation, i.e., the upper, middle, and bottom of the preparation [ 29 , 50 ].…”

Section: Methodsmentioning

confidence: 99%

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

et al. 2020

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α-Mangostin (α-M), one of the active compounds in Garcinia mangostana peel, has been effectively used in wound healing. However, its poor solubility in aqueous solution causes low bioavailability for skin ulcers, hindering its application in wound healing. The aim of this study was to improve the solubility of α-M through complex formation with 2-hydroxypropyl-β-cyclodextrin (α-M/HP-β-CD CX) and to evaluate the healing activity of the complex. The α-M/HP-β-CD CX was incorporated in a sodium carboxymethylcellulose hydrogel (α-M/HP-β-CD CX HG), and the in vivo healing activity was examined in mice. Evaluation of α-M/HP-β-CD CX HG, including organoleptic evaluation, homogeneity, pH, spreadability, swelling ratio, consistency, scanning electron microscopy (SEM), and in vitro drug release, was carried out. The complex formation of α-M/HP-β-CD CX was confirmed by FTIR and PXRD analysis. The solubility of the α-M/HP-β-CD CX in water linearly increased about 11.7-fold compared to α-M alone, and by 3.5-fold compared to the α-M/HP-β-CD physical mixture (α-M/HP-β-CD CX PM). The α-M/HP-β-CD CX HG was homogenous, the pH was found to be in the neutral range, the spread area was 5 cm, and the consistency was stable until 14 days. SEM analysis showed that α-M/HP-β-CD CX HG surged due to the porous structure of the HG. In addition, in vitro release of α-M from α-M/HP-β-CD CX HG was considerably increased compared to α-M/HP-β-CD PM HG and α-M HG. Notably, in vivo evaluation in mice showed that α-M/HP-β-CD CX HG significantly accelerated the wound healing ability compared to other HGs. Thus, α-M/HP-β-CD CX HG has potential as a new formulation of α-M for wound healing therapy.

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Section: Methodsmentioning

confidence: 99%

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

et al. 2020

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“…The use of in situ gel-forming using gum gel can be used for drugs for vaginal use purposes, wherein research conducted by Patel, and Patel in 2015, obtained test results from gum gellan formulations combined with the active substance clindamycin, showing improved texture characteristic results seen from rheological results. The addition of HPMC to the formulation is useful to reduce the sole at the gel transition temperature, as well as also used to affect the mucoadhesive Formulations can be used (Geng et al, 2016) ( Kurniawansyah et al, 2018).…”

Section: Gel Forming Agent Formulation Gel Combination Gellan Gummentioning

confidence: 99%

The Advantages of In situ Gel from Every Different Formulation

Sopyan¹,

Intani²,

S³

et al. 2020

ijrps

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The in situ gel system is one of the polymer-based solutions that show the sol phase transition to gel. In addition to being used to improve bioavailability, this gel is also used to make the drug increase the residence time in the area of use, so that it can provide maximum effectiveness via enhancing of per cent permeation, The use of in situ gel, usually used in ocular administration of drugs, for the treatment of cancer, administration of drugs in the vaginal, rectal, topical, oral, and any route administration. There are many formulations of in situ gel formation that are used for medicinal preparations for many purposes, with different lengths of stay. Searching for articles is done online, browsing the PubMed and Google scholar site with the keyword "Formulation In situ Gel". The fourty articles used, there were 40 in situ gel formulations with gelling agents and also different uses. The purpose of this article review is to look at the superiority of in situ gel formulations and to compare various in situ gel formulations studied from 40 articles used, so that it can be seen which formulation is most often used and has a good effect on drugs preparations.

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“…One ml of each formula was taken with the pipette and transferred slowly on the surface of the fluid, as the solution comes in contact with the gastric fluid solution; it was immediately converted into the gel-like structure. The gelation time was evaluated triplicate based on the period for which gel formed 14,15 .…”

Section: Evaluation Of Floating In-situ Gel Curcumin Solution (In-vitmentioning

confidence: 99%

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2019

IJPSR

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The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 ºC, required quantities of sodium citrate and calcium carbonate were dispersed in it with continuous stirring followed by the addition of curcumin and sorbitol. Identification of drug was confirmed by DSC (melting point study), FTIR (functional groups study), and UV spectrophotometric analysis. Compatibility between drug and polymer were confirmed by DSC and FTIR studies. The micromeritic properties of curcumin were done, and all formulations showed pH in the range of 6.6 to 7.4, floating lag time was less than 1 min, duration of floating was more than 24 h for all the prepared formulations. Gelling capacity, gel strength, viscosity, and water uptake by the gel increased with the increase in sodium alginate concentration; the drug content was found to be in the range of 92.5 to 99.1%. Drug release was found to decrease with the increase in polymer concentration of gel. The release kinetics of all the formulations followed zero order mechanism. INTRODUCTION: Floating oral in-situ gel forming system are widely explored for gastro retention purposes and have a bulk density lower than gastric fluids and thus remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period. While the system is floating on gastric contents, the drug is released slowly at a desired rate from the system.

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Application and Characterization of in Situ Gel

Cited by 18 publications

References 20 publications

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

The Advantages of In situ Gel from Every Different Formulation

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