Applicability of Internal Standardization with Yttrium to the Solid-phase Extraction of Trace Elements in Groundwater and Wastewater Using an Aminocarboxylic Acid-type Chelating Resin

Yokota, Yuki; Gemmei‐Ide, Makoto; Inoue, Yasuhiro; Kagaya, Shigehiro

doi:10.2116/analsci.20p387

Cited by 4 publications

(2 citation statements)

References 57 publications

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“…However, fortunately, we had a different resin at our disposal-Presep ® Poly-Chelate, a chelate resin immobilizing carboxymethylated pentaethylenehexamine [34,35]. Published data suggests that its performance is comparable to those of Nobias Chelate-PA1 and superior to those of some other commercially available aminocarboxilyc acid-type chelating resins [36,37]. Experiments under static conditions have shown that 44 Sc distribution coefficient for this resin is: in 0.1 M HCl-3.8 ± 1.1 mL/g; in 0.2 M HCl-1.9 ± 0.7 mL/g; and for mixture of 0.1 M oxalic acid / 0.2 M HCl->3 × 10 4 mL/g.…”

Section: Presep ® Polychelate Resinmentioning

confidence: 99%

Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

2021

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Today, 44Sc is an attractive radionuclide for molecular imaging with PET. In this work, we evaluated a 44Ti/44Sc radionuclide generator based on TEVA resin as a source of 44Sc. The generator prototype (5 MBq) exhibits high 44Ti retention and stable yield of 44Sc (91 ± 6 %) in 1 mL of eluate (20 bed volumes, eluent—0.1 M oxalic acid/0.2 M HCl) during one year of monitoring (more than 120 elutions). The breakthrough of 44Ti did not exceed 1.5 × 10−5% (average value was 6.5 × 10−6%). Post-processing of the eluate for further use in radiopharmaceutical synthesis was proposed. The post-processing procedure using a combination of Presep® PolyChelate and TK221 resins made it possible to obtain 44Sc-radioconjugates with high labeling yield (≥95%) while using small precursor amounts (5 nmol). The proposed method takes no more than 15 min and provides ≥90% yield relative to the 44Sc activity eluted from the generator. The labeling efficiency was demonstrated on the example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis. Some superiority of PSMA-I&T over PSMA-617 in terms of 44Sc labeling efficiency was demonstrated (likely due to presence of DOTAGA chelator in the precursor structure). It was also shown that microwave heating of the reaction mixture considerably shortened the reaction time and improved radiolabeling yield and reproducibility of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis.

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Section: Presep ® Polychelate Resinmentioning

confidence: 99%

Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

2021

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“…LLE pre-concentration of heavy metals with complexing reagents is a well-developed field [21]. Chelating resin solid-phase extraction with high selectivity is used for chemical separation prior to measurement [22][23][24]. This method eliminates major components, such as seawater salt, and concentrates the analytes to enable highly sensitive and accurate analysis.…”

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confidence: 99%

Water quality monitoring

Tazoe

2023

ANAL. SCI.

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Automated rapid solid-phase extraction system for separation and preconcentration of trace elements using carboxymethylated polyethyleneimine-type chelating resin

et al. 2023

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Applicability of Internal Standardization with Yttrium to the Solid-phase Extraction of Trace Elements in Groundwater and Wastewater Using an Aminocarboxylic Acid-type Chelating Resin

Cited by 4 publications

References 57 publications

Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

Water quality monitoring

Automated rapid solid-phase extraction system for separation and preconcentration of trace elements using carboxymethylated polyethyleneimine-type chelating resin

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