BackgroundStage-3 chronic kidney disease (CKD) is the first stage that is identifiable from a blood test alone. In the UK, it accounts for the majority of people on primary care CKD registers. It also represents a group of people who, in the past, would have gone unnoticed clinically. In order to support patients and plan services, the natural history of stage-3 CKD is important.
AimTo systematically review the natural history of stage-3 CKD in order to describe all cause mortality, cardiovascular morbidity and mortality, and renal outcomes.
Design of studySystematic review of the literature.
MethodMEDLINE and Embase databases were searched from 1998 to February 2009. Systematic reviews and cohort studies that included adults with stage-3 CKD were considered eligible. Studies were appraised and data extracted by one reviewer and checked by a second.