Applicability of disseminated intravascular coagulation parameters in the assessment of the severity of acute pancreatitis

Role of Thrombophilia in Splanchnic Venous Thrombosis in Acute Pancreatitis

“…This is in contrast to previous studies, where higher mortality and multiple organ failure were found to be associated with abnormal procoagulation parameters [12,26]. We found prolongation of PT in most (97.6%) of the patients and prolonged aPTT in only few (4.8%) patients, consistent with previous studies [27,28].…”

Coagulation Abnormalities in Acute Pancreatitis

“…The levels of DIC parameters (low levels of platelets and AT, and high levels of D-dimer) and thrombin-antithrombin complex upon admission have been found to be associated with increased severity and poor prognosis of AP (Maeda et al, 2006). A four-fold increase in Ddimer levels has been shown to be a marker of complicated AP (Salomone et al, 2003).…”

“…In patients with AP, low levels of AT (< 69%) at admission were found to be associated with a poor prognosis (Maeda et al, 2006). In taurocholate-induced experimental pancreatitis in rats, high dose AT treatment was shown to improve survival (Bleeker et al, 1992).…”

“…This study along with others showed that platelets exert a proinflammatory response by invoking MIP-2 chemokine synthesis in pancreatic cells (macrophage and acinar cells) (Ramnath & Bhatia, 2006;Sun & Bhatia, 2007), a major signal for neutrophil infiltration and chemotaxis (Bhatia & Hegde, 2007;Li et al, 2004). Therefore targeting the inflammatory nature of platelets may have therapeutic potential in reducing pancreatic tissue injury and the severity of acute pancreatitis (Abdulla et al, 2011 2009;²Radenkovic et al 2004;³Mavrommatis et al 2000;Kinasewitz et al 2004;Collins et al 2006;Maeda et al 2006;Stief et al 2007;Lindstrom et al 2006;Sawa et al 2006;¹⁰Gando et al 1998;¹¹Powell et al 2001;¹²Ogura et al 2001;¹³Osmanovic et al 2000;¹ Lu et al 2007;¹ Yasuda et al 2009;¹ Uehara et al 2009;¹ Vinazzer et al 1988;¹ Ida et al 2009; †Denotes a non-significant value compared with normal controls. …”

“…While a heightened platelet response is typical of patients with mild AP, a decreased platelet count (due to increased consumption of platelets) is observed in cases of severe AP. Low plasma levels of platelets in patients with AP are also associated with poor clinical outcome (Maeda et al, 2006).…”