Apple Procyanidins Suppress Amyloid<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">β</mml:mi></mml:mrow></mml:math>-Protein Aggregation

Toda, Toshifusa; Sunagawa, Tadahiro; Kanda, Tomomasa; Tagashira, Motoyuki; Shirasawa, Takuji; Shimizu, Takahiko

doi:10.1155/2011/784698

Cited by 31 publications

(20 citation statements)

References 41 publications

(51 reference statements)

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“…We recently demonstrated that PC from apples had Sir2-dependent anti-ageing effects in worms (Caenorhabditis elegans) [9] . Moreover, we demonstrated that PC suppressed amyloid- protein aggregation [14] . However, the preventative effects of AP intaking against aging phenomena caused by endogenous chronic oxidative stress remain to be fully evaluated.…”

mentioning

confidence: 74%

Apple Polyphenols Regulate Mitochondrial Superoxide Generation and Extend Survival in a Mouse Model of Dilated Cardiomyopathy

Sunagawa¹,

Watanabe²,

Yusuke³

et al. 2012

LSMR

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confidence: 74%

Apple Polyphenols Regulate Mitochondrial Superoxide Generation and Extend Survival in a Mouse Model of Dilated Cardiomyopathy

Sunagawa¹,

Watanabe²,

Yusuke³

et al. 2012

LSMR

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“…Specific apple fractions and phytochemicals have been shown to extend the mean lifespan of C. elegans and Drosophila melanogaster, and to suppress amyloid-beta protein aggregation in C. elegans (Sunagawa et al 2011; Peng et al 2011; Toda et al 2011). For example, Sunagawa and coworkers showed that procyanidins from Fuji apples extended the mean lifespan of wild-type C. elegans by 12.1%, an effect that depended on SIR-2, a member of the sirtuin family of NAD+-dependent protein deacetylases.…”

Section: Discussionmentioning

confidence: 99%

Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans

Vayndorf

Lee

Liu

2013

Journal of Functional Foods

103

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Regular consumption of fruits and vegetables is associated with reduced risk of age-related functional decline and chronic diseases such as cancer and cardiovascular disease. These effects are primarily attributed to phytochemicals, plant compounds with a wide range of biological activities and health benefits. Apples, the top contributor of fruit phenolics in American diets, have high antioxidant, antiproliferative and chemopreventive activity in vitro and in vivo. However, little is known about their effects on aging. The objectives of this study were to determine the effects of whole apple phytochemical extracts on lifespan, healthspan and resistance to various stresses in vivo using C. elegans as a model. The mean and maximum lifespan of animals treated with 2.5, 5 and 10 mg/ml whole apple extracts increased significantly in a dose-dependent manner by up to 39 and 25%, respectively. Healthspan also significantly improved as indicated by improved motility and reduced lipofuscin accumulation. Animals pre-treated with whole apple extracts were more resistant to stresses such as heat, UV radiation, paraquat-induced oxidative stress, and pathogenic infection, suggesting that cellular defense and immune system functions also improved. Our findings indicate that, in C. elegans, whole apple extracts slow aging, extend lifespan, improve healthspan, and enhance resistance to stress.

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“…Our results are consistent with data from Toda et al . () where procyanidins (compounds also present in guarana) were potent suppressor of Aβ aggregation, able to suppress Aβ42 aggregation and dissociated Aβ42 aggregates in a dose‐dependent manner. In general, other natural polyphenols have been shown to act on different amyloidogenic proteins by inhibiting amyloid formation (Ferreira et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Guarana (Paullinia cupana Mart.) Prevents β‐Amyloid Aggregation, Generation of Advanced Glycation‐end Products (AGEs), and Acrolein‐Induced Cytotoxicity on Human Neuronal‐Like Cells

Bittencourt

Zeidán-Chuliá

Yatsu

et al. 2014

Phytotherapy Research

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Advanced glycation end-products (AGEs) are considered potent molecules capable of promoting neuronal cell death and participating in the development of neurodegenerative disorders such as Alzheimer's disease (AD). Previous studies have shown that AGEs exacerbate β-amyloid (Aβ) aggregation and AGE-related cross-links are also detected in senile plaques. Acrolein (ACR) is an α, β-unsaturated aldehyde found in the environment and thermally processed foods, which can additionally be generated through endogenous metabolism. The role of ACR in AD is widely accepted in the literature. Guarana (Paullinia cupana Mart.) is popularly consumed by the population in Brazil, mainly for its stimulant activity. In the present study, we showed that guarana (10, 100, and 1000 µg/mL) is able to prevent protein glycation, β-amyloid aggregation, in vitro methylglyoxal, glyoxal, and ACR (20 μM)-induced toxicity on neuronal-like cells (SH-SY5Y). Since these are considered typical AD pathological hallmarks, we propose that guarana may deserve further research as a potential therapeutic agent in such a neurodegenerative disease.

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Apple Procyanidins Suppress Amyloidβ-Protein Aggregation

Cited by 31 publications

References 41 publications

Apple Polyphenols Regulate Mitochondrial Superoxide Generation and Extend Survival in a Mouse Model of Dilated Cardiomyopathy

Apple Polyphenols Regulate Mitochondrial Superoxide Generation and Extend Survival in a Mouse Model of Dilated Cardiomyopathy

Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans

Guarana (Paullinia cupana Mart.) Prevents β‐Amyloid Aggregation, Generation of Advanced Glycation‐end Products (AGEs), and Acrolein‐Induced Cytotoxicity on Human Neuronal‐Like Cells

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