Applanoxidic acids A, B, C and D, biologically active tetracyclic triterpenes from Ganoderma applanatum

Phytochemical investigation, antioxidant and anticholinesterase activities of Ganoderma adspersum

“…By comparing their chemical and spectral data with the literature, compound 1 was identified as applanoxidic acid G (1) (Chairul et al, 1994;Smania et al, 2003;Mothana et al, 2003). The structures of compounds 2 and 3 were identified by comparing their chemical and spectral data with the literature as applanoxidic acid E (2) (Chairul et al, 1991), and applanoxidic acid A (3) (Chairul et al, 1994). The structure of compound 4 was also confirmed as (22E, 24) -24-ethyl-5␣-cholest-22-en-3␤-ol ( 22 -stigmastenol) by comparing spectral data with literature (Rubinstein et al, 1976).…”

Antimicrobial activity of methyl australate from Ganoderma australe

“…Fractions Fr-3 (a mixture of applanoxidic acids) and Fr-5 were not further processed during the present study. The known compounds, including australic acid, were identifi ed by comparison of the NMR data with those reported in the literature (Chairul et al, 1991;Chairul et al, 1994;Yoshikawa et al, 2002;León et al, 2003).…”

Highly Oxygenated Lanostane Triterpenoids from the Fungus Ganoderma applanatum

“…have also been used in traditional medicines for the treatment of cancer, hypertension, chronic bronchitis, diabetes, and arteriosclerosis and as a tonic or sedative. In the case of G. applanatum (ϭElfvingia applanata), some highly oxygenated lanostane triterpenoids, [2][3][4][5][6] such as ganoderenic acids, ganoderic acids, applanoxidic acids and elfvingic acids, were also isolated in addition to several meroterpenoids. 7,8) In a continuation of the studies on the bioactive principles of higher fungi from China, we have conducted a further chemical study on G. applanatum.…”

“…7,8) In a continuation of the studies on the bioactive principles of higher fungi from China, we have conducted a further chemical study on G. applanatum. Two new highly oxygenated lanostane triterpenoids, ganoderic acid AP2 (1) and ganoderic acid AP3 (2), were isolated from the fruiting bodies along with four known analogues, ganoderenic acids A, B, D and G (3)(4)(5)(6). We describe here the isolation and structure elucidation of the new triterpene acids.…”

“…The above-mentioned NMR data suggested that compound 1 was an acetylated lanostanetype triterpene acid, and this conclusion was also in accordance with the previous study in which the fungus was considered a rich source of lanostane derivatives. [2][3][4][5][6] The signal at d H 3.24 (dd, Jϭ11.0, 5.1 Hz) was typical for the H-3a in the overwhelming triterpenoids, and the observed HMBC correlations ( Fig. 2) from this proton to two tertiary methyl cabons d C 15.7 (q, C-29), 28.2 (q, C-28) further indicated the presence of a hydroxyl at C-3.…”