Appetite and weight gain suppression effects of alcohol depend on the route and pattern of administration in Long Evans rats

Nelson, Nnamdi G.; Suhaidi, Faten A.; DeAngelis, Ross; Liang, Nu-Chu

doi:10.1016/j.pbb.2016.10.006

Cited by 12 publications

(7 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, alcohol did not affect body weight gain in female rats, while alcohol attenuated body weight gain in the male group. In a previous animal study, a single 3 g/kg ethanol injection after injection of 1 g/kg ethanol for 2 weeks reduced appetite and weight gain in male Long Evans rats [ 33 ], similar to the findings in male rats in our study. However, another study using voluntary ethanol drinking exposure found no effects of ethanol on weight gain in either sex [ 33 ].…”

Section: Discussionsupporting

confidence: 92%

“…In a previous animal study, a single 3 g/kg ethanol injection after injection of 1 g/kg ethanol for 2 weeks reduced appetite and weight gain in male Long Evans rats [ 33 ], similar to the findings in male rats in our study. However, another study using voluntary ethanol drinking exposure found no effects of ethanol on weight gain in either sex [ 33 ]. In a study by Kolota et al [ 34 ], body weight gain in adolescent (3-week-old) male rats that received solutions of alcoholic beverages (ethanol, red wine, and beer) for 6 weeks was attenuated in all experimental groups, particularly the beer-drinking group, compared to the control group.…”

Section: Discussionsupporting

confidence: 92%

“…In a study by Kolota et al [ 34 ], body weight gain in adolescent (3-week-old) male rats that received solutions of alcoholic beverages (ethanol, red wine, and beer) for 6 weeks was attenuated in all experimental groups, particularly the beer-drinking group, compared to the control group. Our results and those of Nelson et al [ 33 ] suggest that the duration of alcohol administration and weight gain in male rats are inversely proportional; however, further research is needed to address the inconsistency with regard to changes in body weight gain in male rats during voluntary drinking of alcohol. On the other hand, body weight gain in female rats was not affected by alcohol regardless of the method of alcohol exposure.…”

Section: Discussionsupporting

confidence: 46%

See 2 more Smart Citations

Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration

et al. 2020

View full text Add to dashboard Cite

Background Women are more vulnerable than men to the neurotoxicity and severe brain damage caused by chronic heavy alcohol use. In addition, brain damage due to chronic heavy alcohol use may be associated with sex-dependent epigenetic modifications. This study aimed to identify microRNAs (miRNAs) and their target genes that are differentially expressed in the hippocampi of male and female animal models in response to alcohol. Methods After chronic alcohol administration (3~3.5 g/kg/day) in male (control, n = 10; alcohol, n = 12) or female (control, n = 10; alcohol, n = 12) Sprague-Dawley rats for 6 weeks, we measured body weights and doublecortin (DCX; a neurogenesis marker) concentrations and analyzed up- or downregulated miRNAs using GeneChip miRNA 4.0 arrays. The differentially expressed miRNAs and their putative target genes were validated by RT-qPCR. Results Alcohol attenuated body weight gain only in the male group. On the other hand, alcohol led to increased serum AST in female rats and decreased serum total cholesterol concentrations in male rats. The expression of DCX was significantly reduced in the hippocampi of male alcohol-treated rats. Nine miRNAs were significantly up- or downregulated in male alcohol-treated rats, including upregulation of miR-125a-3p, let-7a-5p, and miR-3541, and downregulation of their target genes (Prdm5, Suv39h1, Ptprz1, Mapk9, Ing4, Wt1, Nkx3-1, Dab2ip, Rnf152, Ripk1, Lin28a, Apbb3, Nras, and Acvr1c). On the other hand, 7 miRNAs were significantly up- or downregulated in alcohol-treated female rats, including downregulation of miR-881-3p and miR-504 and upregulation of their target genes (Naa50, Clock, Cbfb, Arih1, Ube2g1, and Gng7). Conclusions These results suggest that chronic heavy alcohol use produces sex-dependent effects on neurogenesis and miRNA expression in the hippocampus and that sex differences should be considered when developing miRNA biomarkers to diagnose or treat alcoholics.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 46%

See 1 more Smart Citation

Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The epididymal and retroperitoneal fat pads of each rat were dissected and weighed by researchers blinded to the group assignment. Visceral fat composition was calculated with reference to the body weight on the day of sacrifice 59 .…”

Section: Methodsmentioning

confidence: 99%

Joint and separate exposure to alcohol and ∆9-tetrahydrocannabinol produced distinct effects on glucose and insulin homeostasis in male rats

Nelson

Weingarten

Law

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

Cannabis and alcohol co-use is common, and the trend may increase further given the current popularity of cannabis legalization. However, the metabolic consequences of such co-use are unclear. Here, we investigated how co-administration of alcohol and ∆ 9 -tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, affects body weight and visceral adiposity, and glucose and insulin homeostasis in rats. For 16 consecutive days during adolescence, male rats drank saccharin or alcohol after receiving subcutaneous oil or THC injections in Experiment 1 and voluntarily consumed alcohol, THC edible, or both drugs in Experiment 2. Experiment 1 showed that following abstinence, drug co-exposure reduced visceral fat and the amount of insulin required to clear glucose during an oral glucose tolerance test (OGTT). In Experiment 2, rats received a high-fat diet (HFD) after 3-week abstinence. Although adolescent drug use did not interact with the HFD to worsen hyperglycemia and hyperinsulinemia during an OGTT, HFD-fed rats that co-used alcohol and THC had the lowest insulin levels 75 min after an insulin injection, suggesting an altered rate of insulin secretion and degradation. These results suggest that THC and alcohol co-exposure can distinctly alter the physiology of glucose and insulin homeostasis in a rodent model.

show abstract

“…In the human and animal literature, reports on the effects of alcohol on appetite and cognition are mixed (Dry et al 2012;Spear 2018;Yeomans 2010). We previously showed that the route of alcohol administration (oral vs. parenteral) and the time course of blood ethanol concentration (BEC) dictate the effects of alcohol on food intake in rats (Nelson et al 2016). Rats that drank moderate amounts of alcohol aptly reduced their food intake to maintain their daily caloric intake and weight gain at the level of controls.…”

Section: Introductionmentioning

confidence: 99%

Combined ∆9-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats

et al. 2018

Self Cite

View full text Add to dashboard Cite

Rationale-Whereas co-use of alcohol and marijuana is prevalent in adolescents, the effects of such drug co-exposure on ingestive and cognitive behaviors remain largely unexplored. We hypothesized that co-exposure to alcohol and Δ 9-tetrahydrocannabinol (THC), the main psychoactive constitute of marijuana, alters feeding behavior and cognition differently from either drug alone. Methods-Male rats received daily THC (3-20 mg/kg/day) or oil vehicle through subcutaneous injection or consumption of a cookie with access to saccharin or saccharin-sweetened alcohol during adolescence (P30-45). Barnes maze and sucrose preference tests were applied to assess spatial memory and behavioral flexibility and abstinence-related anhedonia, respectively. Results-Subcutaneous THC did not affect alcohol intake, but dose-dependently increased acute (3-h) chow intake and reduced weight gain. Moderate alcohol consumption reduced the acute hyperphagic effect of subcutaneous THC. By contrast, oral THC at a dose > 5 mg/kg robustly reduced alcohol intake without affecting 3-h chow intake. At this dose, some rats stopped consuming the THC-laced cookies. Furthermore, oral THC reduced weight gain, and co-exposure to alcohol alleviated this effect. Chronic subcutaneous, but not oral, THC reduced sucrose intake during abstinence. Neither treatment impaired cognitive behaviors in the Barnes maze. Conclusion-Moderate alcohol and THC consumption can interact to elicit unique outcomes on ingestive behaviors and energy balance. Importantly, this study established a novel model of voluntary alcohol and THC consumption for studying mechanisms underlying the consequences of adolescent onset co-use of the two drugs.

show abstract

Appetite and weight gain suppression effects of alcohol depend on the route and pattern of administration in Long Evans rats

Cited by 12 publications

References 62 publications

Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration

Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration

Joint and separate exposure to alcohol and ∆9-tetrahydrocannabinol produced distinct effects on glucose and insulin homeostasis in male rats

Combined ∆9-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats

Contact Info

Product

Resources

About