Appendicitis in the young child: A continuing diagnostic challenge

Nance, Michael L.; Adamson, William; Hedrick, Holly L.

doi:10.1097/00006565-200006000-00005

Cited by 170 publications

(128 citation statements)

References 7 publications

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“…Furthermore, communication difficulties related to the young age of a pediatric patient can make a diagnosis more time-consuming and difficult, compared to adults [3]. A misdiagnosis rate of 28% -57% has been reported in children ≤ 12-years-of-age [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Fever and Leukocytosis in Diagnosis of Acute Appendicitis in Children Who Visit Emergency Department With Abdominal Pain

2012

Int J Clin Pediatr

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Section: Introductionmentioning

confidence: 99%

Clinical Significance of Fever and Leukocytosis in Diagnosis of Acute Appendicitis in Children Who Visit Emergency Department With Abdominal Pain

2012

Int J Clin Pediatr

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“…Нозологический профиль пациентов, перенесших хирурги-ческое вмешательство (n=12) ОБСУЖДЕНИЕ Боль в животе, лихорадка, рвота, разжиженный стул являются неспецифическими симптомами различных заболеваний [17]. Своевременная диагностика острой хирургической патологии, прежде всего аппендицита, определяет прогноз болезни и объем лечебно-диагно-стических мероприятий [18].…”

Section: статистический анализunclassified

Express Immunochromatographic Detection of Rotavirus and Adenovirus Antigens in Pre-Hospital Differential Diagnosis of Acute Abdominal Pain in Children

et al. 2018

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“…Severe cramps, painful urination, and constipation or diarrhea with gas may also be seen in patients with acute appendicitis. These clinical symptoms result in confusion between acute appendicitis and a number of other conditions, especially nonspecific abdominal pain [1]. Various biochemical markers such as the C-reactive protein (CRP) level, neutrophil percentage, white blood cell (WBC) count, serum 5-hydroxyindoleacetic acid and neutrophil gelatinase-associated lipocalin levels, and various scoring systems are currently used to aid the clinical diagnosis [2]- [6].…”

Section: Introductionmentioning

confidence: 99%

Leptin and NUCB2/Nesfatin-1 in Acute Appendicitis

Bakal¹,

Saraç²,

Çiftçi³

et al. 2015

IJCM

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Objective: Appetite loss is seen in 90% to 95% of patients with acute appendicitis; however, the cause of this symptom remains unknown. This study is performed to determine whether changes in the blood levels of two anorexigenic hormones, leptin and NUCB2/nesfatin-1, can help to diagnose acute appendicitis in children and whether these two parameters can distinguish acute appendicitis from abdominal pain. Methods: Sixty children with comparable ages and body mass indices are divided into three groups of 20 children each: those with acute appendicitis, those with abdominal pain, and controls. The blood sample with acute appendicitis is taken preoperatively (T1), and subsequent samples are taken 24 hrs postoperatively (T2) and 3 days postoperatively (T3). The blood sample with abdominal pain subjects is also taken in the corresponding times with those with acute appendicitis while blood sample from controls is only taken in the T1 corresponding time. Leptin and NUCB2/nesfatin-1 levels are measured by enzyme-linked immunosorbent assay. Results: The serum leptin levels are significantly higher preoperatively than postoperatively in all three groups. The NUCB2/nesfatin-1 levels at T1 in acute appendicitis are significantly higher than those at T2 in all three groups, but are restored at T3 to levels similar to those of controls. Neutrophil percentage has a sensitivity of 100%, and specificity of 76.32%, NUCB2/ nesfatin-1 level has a sensitivity of 47% and specificity of 95%, and the leptin level has a sensitivity of 64% and specificity of 51% in the diagnosis of acute appendicitis. Conclusions: High preoperative leptin and NUCB2/nesfatin-1 levels may be a causative factor for appetite suppression observed in patients with acute appendicitis. High preoperative and low postoperative serum leptin and NUCB2/nesfatin-1 concentrations may serve as new candidate biomarkers that help to distinguish acute appendicitis from abdominal pain in children in addition to high CRP concentration, high WBC count, and neutrophilia.

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Appendicitis in the young child: A continuing diagnostic challenge

Abstract: Appendiceal perforation continues to be a common occurrence in the young child and increases in frequency as the age of the patient decreases and the duration of symptoms lengthens. Perforation results in a significant increase in hospital length of stay and rate of abscess formation.

Cited by 170 publications

References 7 publications

Clinical Significance of Fever and Leukocytosis in Diagnosis of Acute Appendicitis in Children Who Visit Emergency Department With Abdominal Pain

Clinical Significance of Fever and Leukocytosis in Diagnosis of Acute Appendicitis in Children Who Visit Emergency Department With Abdominal Pain

Express Immunochromatographic Detection of Rotavirus and Adenovirus Antigens in Pre-Hospital Differential Diagnosis of Acute Abdominal Pain in Children

Leptin and NUCB2/Nesfatin-1 in Acute Appendicitis

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