Appendicitis in childhood hematologic malignancies: analysis and comparison with typhilitis

Hobson, Michael J.; Carney, David E.; Molik, Kimberly A.; Vik, Terry A.; Scherer, L.R.; Rouse, Thomas M.; West, Karen W.; Grosfeld, Jay L.; Billmire, Deborah F.

doi:10.1016/j.jpedsurg.2004.09.048

Cited by 51 publications

(58 citation statements)

References 15 publications

(32 reference statements)

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“…Localized right lower quadrant abdominal tenderness was reported to occur in only 3 of 7 patients with appendicitis and hematologic malignancy, and 2 of the 7 patients did not have abdominal pain. 3 Our patient also did not complain of abdominal pain.…”

Section: Discussionsupporting

confidence: 48%

“…[1][2][3][4] It was similar to the incidence of appendicitis in the general pediatric population. In children with leukemia, the abdominal tenderness and signs of peritoneal irritation (rebound tenderness, involuntary guarding, and abdominal wall rigidity), usually caused by appendicitis, are frequently blunted by the administration of chemotherapeutic agents including corticosteroids.…”

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confidence: 52%

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Meralgia Paresthetica as a Presentation of Acute Appendicitis in a Girl With Acute Lymphoblastic Leukemia

Nishimura

Kodama²,

Fukano³

et al. 2015

Journal of Pediatric Hematology/Oncology

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A 7-year-old girl with Philadelphia chromosome-positive acute lymphoblastic leukemia developed recurrent fever and meralgia paresthetica (MP) during chemotherapy, which resolved after administration of antibiotics. Five months after the onset of these symptoms, enhanced computed tomography showed a periappendiceal abscess extending into the psoas muscle. The cause of her fever and MP was thought to be appendicitis, which probably developed during induction chemotherapy but did not result in typical abdominal pain. Patients with recurrent fever and MP should be evaluated by imaging examinations including computed tomography to search for appendicitis.

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Section: Discussionsupporting

confidence: 48%

supporting

confidence: 52%

Meralgia Paresthetica as a Presentation of Acute Appendicitis in a Girl With Acute Lymphoblastic Leukemia

Nishimura

Kodama²,

Fukano³

et al. 2015

Journal of Pediatric Hematology/Oncology

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“…The difficulty in distinguishing appendicitis from nonsurgical abdominal pain in this complex population is becoming simplified with use of ultrasound and computed tomography (CT) [10]. In our series, all patients underwent an abdominal CT to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Appendicitis in Neutropenic Children

Mortellaro

Juang

Fike

et al. 2011

Journal of Surgical Research

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“…The causes of abdominal pain were necrotizing enterocolitis (n = 17; 28%), small bowel obstruction (n = 7; 12%), diverticulitis (n = 3; 5%), appendicitis (n = 3; 5%), cholecystitis (n = 2; 3%), colonic pseudo-obstruction (n = 2; 3%), splenic rupture (n = 1; 2%), and no definite cause (n = 21; 35%). These diagnoses can be difficult to distinguish using imaging technology [6]. In our case, patients underwent abdominal CT to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 86%

Treatment of Acute Appendicitis in the Patients With Severe Neutropenia

Kang¹

2013

J Med Cases

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When appendicitis occurs in neutropenic adult patients, clinicians must balance the timing and the risks of surgery. Urgent surgery may lead to high operative complications and mortality. This case report details the treatment of appendicitis in neutropenic patients with hematologic disease. Patient 1 was a 31 years old female with severe aplastic anemia and patient 2 was a 34 years old male with AML M6. Both patients' abdominal CT scan was suggestive of appendicitis. We prepared supportive care first, delayed surgery was successfully completed without acute or late complications. We suggest that, in patients in a neutropenic state, delayed elective operation is superior to urgent operation, except in the case of lifethreatening complications such as peritonitis.

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Appendicitis in childhood hematologic malignancies: analysis and comparison with typhilitis

Cited by 51 publications

References 15 publications

Meralgia Paresthetica as a Presentation of Acute Appendicitis in a Girl With Acute Lymphoblastic Leukemia

Meralgia Paresthetica as a Presentation of Acute Appendicitis in a Girl With Acute Lymphoblastic Leukemia

Treatment of Appendicitis in Neutropenic Children

Treatment of Acute Appendicitis in the Patients With Severe Neutropenia

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