Appendiceal Orifice Inflammation in Ulcerative Colitis

Hokama, Akira; Ihama, Yasushi; Chinen, Hiroshi; Kishimoto, Kazuto; Kinjo, Fukunori; Fujita, Jiro

doi:10.1007/s10620-009-0840-2

Cited by 5 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, a large cohort study found that combining proctitis and AOI features could improve UC diagnosis and facilitate physicians to identify this disorder among various conditions 16. Furthermore, the current study found that UC patients with AOI developed less severe disease than those without, as reflected by lower modified Mayo scores, and these findings were supported by previous reports 8 9. Skip lesions were previously thought only to be characteristic of Crohn’s disease.…”

Section: Discussionsupporting

confidence: 87%

“…The presence of AOI has been reported in UC patients, and its significance in UC has been investigated. However, the results are controversial 1 6–9 14–16. In this study, the significance of AOI in UC diagnosis and prognosis was prospectively studied.…”

Section: Discussionmentioning

confidence: 95%

“…For instance, UC patients with AOI have better prognoses, minor disease progressions and fewer medical intervention demands than those without AOI. 9 In addition, UC patients who received appendectomies had a lower recurrence rate and disease activity than those who did not, and AOI has been considered a marker of active UC. 10 However, there are currently limited qualitative studies regarding the prognosis of UC with AOI.…”

Section: Introductionmentioning

confidence: 99%

“…Although some investigators suggest that AOI does not significantly affect UC prognosis,1 6–8 an increasing number of studies have indicated that the presence of AOI possesses potential clinical implications. For instance, UC patients with AOI have better prognoses, minor disease progressions and fewer medical intervention demands than those without AOI 9. In addition, UC patients who received appendectomies had a lower recurrence rate and disease activity than those who did not, and AOI has been considered a marker of active UC 10.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Significance of diagnosis and prognosis for appendiceal orifice inflammation in ulcerative colitis: a real-world study

et al. 2022

View full text Add to dashboard Cite

ObjectiveUlcerative colitis (UC) is a chronic inflammatory disease of the large intestine. At present, the significance of appendiceal orifice inflammation (AOI) in UC prognosis is still controversial. This prospective observational study investigated the importance of AOI in UC diagnosis and prognosis. Additionally, it compared the therapeutic efficacy of treatments in UC patients with or without AOI.DesignThis study was a prospective, observational, single-centre, real-world study. Patients with AOI were included in the observation group, and patients without AOI were assigned to the control group. All patients were followed up for 1 year; the disease remission and treatment efficacy were re-examined by colonoscopy. In addition, the clinical, endoscopic and pathological features were collected before and after the treatment.ResultsPatients with endoscopic diffuse inflammatory changes in the distal colorectum accompanied by AOI had a higher positive UC diagnosis rate than those without (96.5% vs 78.0%). Also, AOI had a specificity of 95.2% and a sensitivity of 28.3% for UC diagnosis. However, no difference in the modified Mayo score (p=0.881) or Baron grading was observed between the control and observation groups, indicating that AOI does not affect the treatment outcome of UC patients.ConclusionIn this study, the observation of AOI improved the UC diagnostic accuracy in patients with diffuse lesions in the distal colorectum. Furthermore, the presence of AOI does not affect the treatment efficacies of UC.Trial registration numberChiCTR1800017753.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Significance of diagnosis and prognosis for appendiceal orifice inflammation in ulcerative colitis: a real-world study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Ulcerative colitis is a continuous disease, however, in rare cases skip lesions may be found scattered within the colon. The appendix may be involved in the process, particularly in the case of cecal involvement although ulcerative appendicitis may represent a skip lesion [10][11][12]. There is controversy whether appendicitis/appendectomy are protective against UC or might promote the disease [13].…”

mentioning

confidence: 99%

Non-Operative Management of Acute Appendicitis in a Patient with Ulcerative Colitis

TierneyJoshua¹,

MelvinWillie²,

MayAddison³

et al. 2016

Surgical Infections Case Reports

View full text Add to dashboard Cite

Background: Right lower quadrant (RLQ) pain is a common reason for visits to the emergency department. Acute appendicitis is often suspected but multiple other differential diagnoses must be taken into consideration including inflammatory bowel disease (IBD). A computed tomography (CT) scan of the abdomen is used routinely in adults presenting to the emergency department with RLQ pain. Ulcerative colitis (UC) may affect the appendix in cases of pancolitis, however, skip lesions in the appendix have been reported rarely. Nonoperative management of appendicitis has gained increasing acceptance. Case Presentation: A 49-year-old male with UC, who was non-compliant with therapy, presented to the emergency department with acute RLQ pain and diarrhea. Computed tomography scan showed a thickened and dilated appendix, peri-appendiceal stranding, and mild thickening of the cecum. We suspected the patient had a flare of UC involving the appendix and opted for non-operative management with intravenous antibiotics. His pain improved and colonoscopy revealed active pancolitis involving the cecum. Biopsies confirmed the diagnosis of a flare of UC. He was discharged with a course of antibiotics and followed as an outpatient and started on medication for UC. He remained well during follow-up without evidence of recurrent appendicitis. Discussion: Increasing evidence is available to support non-operative management of patients with acute appendicitis. We propose that patients with IBD who present with acute RLQ pain and CT findings of acute appendicitis should be managed non-operatively and a colonoscopy should be done to exclude active IBD. Appendectomy in a patient with active colitis may have an increased risk of morbidity such as stump leak or cecal perforation and may delay initiation of appropriate therapy.

show abstract

Animal Models of Inflammatory Bowel Disease for Drug Discovery

Mizoguchi

Andoh

2013

Animal Models for the Study of Human Disease

View full text Add to dashboard Cite

Appendiceal Orifice Inflammation in Ulcerative Colitis

Cited by 5 publications

References 4 publications

Significance of diagnosis and prognosis for appendiceal orifice inflammation in ulcerative colitis: a real-world study

Significance of diagnosis and prognosis for appendiceal orifice inflammation in ulcerative colitis: a real-world study

Non-Operative Management of Acute Appendicitis in a Patient with Ulcerative Colitis

Animal Models of Inflammatory Bowel Disease for Drug Discovery

Contact Info

Product

Resources

About