Appendiceal neoplasms—A practical guide

Rossi, Antonello; Patel, Nell Maloney

doi:10.1002/jso.27304

Cited by 7 publications

(10 citation statements)

References 73 publications

(180 reference statements)

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“…In previous studies, several risk factors for potential appendiceal malignancy were reported: age ≥ 50 years, atypical symptoms, presence of appendiceal phlegmon [ 19 ] or dilatation of the appendix [ 25 ] in radiological findings, immunosuppressive therapy including the use of steroids [ 19 , 34 ], absence of leucocytosis [ 25 ], and elevated CRP ≥ 54 mg/l [ 15 ]. Furthermore, female sex [ 28 ], ASA score ≥ 2, Crohn’s disease, anaemia on admission [ 15 , 19 ] and a history of previous malignancy [ 19 ] were found to be risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of sessile serrated adenomas is estimated in one out of 1100 appendectomy specimens and the majority is found incidentally [ 41 ]. It is postulated that these lesions reveal in contrast to colorectal serrated lesions high rates of KRAS and lower rates of BRAF 500 mutations [ 34 ]. Serrated lesions of the appendix are limited to the muscularis mucosae and lamina propria, so that a complete resection for treatment is sufficient as performed in the underlying investigation [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is postulated that these lesions reveal in contrast to colorectal serrated lesions high rates of KRAS and lower rates of BRAF 500 mutations [ 34 ]. Serrated lesions of the appendix are limited to the muscularis mucosae and lamina propria, so that a complete resection for treatment is sufficient as performed in the underlying investigation [ 34 ]. A routine colonoscopy to rule out other lesions in the colon should be performed.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective analysis of the incidence of appendiceal neoplasm and malignancy in patients treated for suspected acute appendicitis

Dohner,

Kierdorf,

Langer

et al. 2024

BMC Surg

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Background Nonoperative management of uncomplicated appendicitis is currently being promoted as treatment option, albeit 0.7–2.5% of appendectomies performed due to suspected acute appendicitis show histologically malignant findings. The purpose of this study was to investigate the incidence of neoplasm and malignancy of the appendix in patients presenting with suspected acute appendicitis in real world setting. Methods This is a retrospective single-centre investigation of 457 patients undergoing appendectomy between the years 2017–2020. The patients’ demographics, symptoms and diagnosis, intraoperative findings, and histopathological results were analysed. Results In 3.7% (n = 17) histological analysis revealed neoplasms or malignancies. Median age was 48 years (20–90 years), without sex predominance. Leukocytes (11.3 ± 3.7 G/l) and C-reactive protein (54.2 ± 69.0 mg/l) were elevated. Histological analysis revealed low-grade mucinous appendiceal neoplasia (n = 3), sessile serrated adenoma of the appendix (n = 3), neuroendocrine tumours (n = 7), appendiceal adenocarcinoma of intestinal type (n = 3), and goblet cell carcinoma (n = 1). Additional treatment varied between no treatment or follow-up due to early tumour stage (n = 4), follow-up care (n = 3), additional surgical treatment (n = 8), or best supportive care (n = 2). Conclusions Preoperative diagnosis of appendiceal tumours is difficult. Nonoperative management of patients with acute, uncomplicated appendicitis potentially prevents the correct diagnosis of malignant appendiceal pathologies. Therefore, close follow-up or surgical removal of the appendix is mandatory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retrospective analysis of the incidence of appendiceal neoplasm and malignancy in patients treated for suspected acute appendicitis

Dohner,

Kierdorf,

Langer

et al. 2024

BMC Surg

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“…Appendiceal sessile serrated polyps are precursor adenomatous lesions proximal to the muscularis mucosa and lamina propria with malignant potential, have different histopathological features compared to colorectal serrated polyps, and undergo malignant transformation through different pathways with the conventional 'adenoma-carcinoma sequence' [20]. In addition, colonoscopic examination is recommended in patients with appendix sessile serrated lesions since the incidence of synchronous colorectal lesions is approximately four times higher compared to the overall population [21].…”

Section: Discussionmentioning

confidence: 99%

Histopathological examination after appendectomy: Neoplastic lesions

Ciftci,

Ucaner

2023

Med-Science

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Appendiceal neoplasms include rare tumor formations, whose treatment ranges from an appendectomy, hemicolectomy, and chemotherapeutic agents for benign or malignant lesions. In this study, we aimed to evaluate appendiceal neoplastic lesions according to the literature on histological subgroups. A review was performed on 2.124 patients who had undergone appendectomy between January 2017 and December 2021. Patients were evaluated retrospectively according to their demographic, clinical, radiological, and histopathological characteristics. In the histopathological evaluation of the 23 (1.06%) patients, who were included in the study upon the detection of the appendiceal neoplastic lesion, sessile serrated adenoma was observed in 7 patients, low-grade appendiceal mucinous neoplasm (LAMN) in 6 patients, mucinous adenocarcinoma in 4 patients, signet ring cell mucinous adenocarcinoma in 1 patient, neuroendocrine tumor (NET) in 4 patients, and tubulovillous adenoma in 1 patient. Appendiceal neoplasms are generally asymptomatic; therefore, pathological examination results should be carefully evaluated after appendectomy, and it should be remembered that appendectomy is not always sufficient alone.

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“…Appendiceal tumors are frequently identified incidentally during radiological examinations or abdominal surgery, with these procedures often being prompted by tumor-induced acute appendicitis. Accurate preoperative diagnosis is challenging and is typically confirmed by pathological analysis after resection [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review

Yagyu,

Miki,

Kikawa

et al. 2024

Cureus

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Appendiceal metastases of breast cancer (BC) are very rare, and there are few reports of resection. Asymptomatic appendiceal enlargement is often suspected to be a primary appendiceal tumor, making it difficult to suspect metastatic tumors, especially metastases from BC. On the other hand, advances in drug therapy, including hormonal therapy for BC, have prolonged survival, and there is a possibility of encountering metastatic cases that have rarely been seen before. We herein present a case in which an enlarged appendix, identified during hormonal therapy for advanced BC, was laparoscopically removed and diagnosed as BC metastasis. A 53-year-old woman had been diagnosed with invasive ductal carcinoma (IDC) based on a breast biopsy, and the appendiceal specimen was diagnosed as invasive lobular carcinoma (ILC). We herein report this unique case and provide a detailed review of 13 previous reports.

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Appendiceal neoplasms—A practical guide

Cited by 7 publications

References 73 publications

Retrospective analysis of the incidence of appendiceal neoplasm and malignancy in patients treated for suspected acute appendicitis

Retrospective analysis of the incidence of appendiceal neoplasm and malignancy in patients treated for suspected acute appendicitis

Histopathological examination after appendectomy: Neoplastic lesions

Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review

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