Appendiceal carcinoids in children—management and outcomes

Kim, Sara S; Kays, David W.; Larson, Shawn D.; Islam, Saleem

doi:10.1016/j.jss.2014.06.031

Cited by 28 publications

(29 citation statements)

References 12 publications

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“…Similarly, reports of invasive disease either to the mesoappendix or with lymph node invasion (only six with lymph node invasion for all patients) were limited, suggesting that the rate of invasive disease is truly rare. Of note, only half of the studies discussed their center's approach to surveillance imaging, which ranged from imaging and laboratories for "high risk" patients to specific imaging and time duration (i.e., ultrasound every 3 mo for 1 y, then yearly for 5 y) [4,15].…”

Section: Discussionmentioning

confidence: 99%

“…Barriers to the development of treatment algorithms in children include the rarity of the disease with limited singleinstitution experience and a lack of a defined natural history of these tumors [3]. Additionally, comparison to adult literature has limitations as these tumors behave differently in children [4,5]. At our institution, postoperative management guidelines have been developed for patients with acute appendicitis.…”

Section: Introductionmentioning

confidence: 99%

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Management of appendiceal carcinoid tumors in children

Fallon

Hicks

Carpenter

et al. 2015

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Management of appendiceal carcinoid tumors in children

Fallon

Hicks

Carpenter

et al. 2015

Journal of Surgical Research

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“…The extent of surgical resection in case of suspected malignancy depends on the location and size of the appendicular mass [150–154]. Routine inclusion of the meso-appendix with the appendectomy is advised.…”

Section: Intra-operative Unexpected Findingsmentioning

confidence: 99%

“…In cases of a NET > 1 cm, LAMN grade 3–4 or an adenocarcinoma of the appendix, a formal right hemicolectomy is indicated to provide an oncologically sufficient resection. It is advised to perform a total meso-appendicular resection at the primary operation and an additional hemicolectomy at a later stage when indicated (Tables 5, 6, 7, 8) [150–154]. …”

Section: Intra-operative Unexpected Findingsmentioning

confidence: 99%

Diagnosis and management of acute appendicitis. EAES consensus development conference 2015

et al. 2016

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Unequivocal international guidelines regarding the diagnosis and management of patients with acute appendicitis are lacking. The aim of the consensus meeting 2015 of the EAES was to generate a European guideline based on best available evidence and expert opinions of a panel of EAES members. After a systematic review of the literature by an international group of surgical research fellows, an expert panel with extensive clinical experience in the management of appendicitis discussed statements and recommendations. Statements and recommendations with more than 70 % agreement by the experts were selected for a web survey and the consensus meeting of the EAES in Bucharest in June 2015. EAES members and attendees at the EAES meeting in Bucharest could vote on these statements and recommendations. In the case of more than 70 % agreement, the statement or recommendation was defined as supported by the scientific community. Results from both the web survey and the consensus meeting in Bucharest are presented as percentages. In total, 46 statements and recommendations were selected for the web survey and consensus meeting. More than 232 members and attendees voted on them. In 41 of 46 statements and recommendations, more than 70 % agreement was reached. All 46 statements and recommendations are presented in this paper. They comprise topics regarding the diagnostic work-up, treatment indications, procedural aspects and post-operative care. The consensus meeting produced 46 statements and recommendations on the diagnostic work-up and management of appendicitis. The majority of the EAES members supported these statements. These consensus proceedings provide additional guidance to surgeons and surgical residents providing care to patients with appendicitis. Electronic supplementary materialThe online version of this article (doi:10.1007/s00464-016-5245-7) contains supplementary material, which is available to authorized users.

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“…[6] WHO released the present classification system for the digestive system based on histologic grade in 2010. [5–7] This classification divides NETs into well differentiated, including low-grade (G1) and intermediate-grade (G2) neuroendocrine neoplasms, and poorly differentiated, high-grade (G3) neuroendocrine carcinoma. This present classification system brought the WHO system more closely in line with other widely used systems including the European Neuro Endocrine Tumors (ENETs) classification system.…”

Section: Introductionmentioning

confidence: 99%

Well-differentiated neuroendocrine tumor of the stomach

et al. 2016

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Introduction:A 13-year-old African–American female presented to her primary care physician's office with fatigue, syncope, and hematemesis. After initial evaluation, the patient was referred to pediatric gastroenterology clinic for further evaluation.Main concerns, important findings:An upper gastrointestinal endoscopy was performed to evaluate the source of her bleeding. Endoscopy revealed a 3-cm mass in the lesser curvature of the stomach, and a biopsy of the mass revealed a concern for carcinoid (neuroendocrine) features.Diagnosis:She underwent an open gastrectomy. Post-surgical pathology reports confirmed a well-differentiated neuroendocrine tumor of the stomach.Conclusion:Neuroendocrine tumors of the stomach in children are rare and we presently do not have pediatric-specific diagnostic and treatment guidelines. Although adult-based The North American Neuroendocrine Tumor Society (NANETS) guidelines are helpful, they are clearly not geared toward pediatric patients. To establish pediatric guidelines and to assess effectiveness of treatments, multicenter data collection is essential. In the long run, accumulation of clinically useful treatment information and long-term follow-up guidelines should enable clinicians to improve standard of care given to children with neuroendocrine tumors.

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Appendiceal carcinoids in children—management and outcomes

Cited by 28 publications

References 12 publications

Management of appendiceal carcinoid tumors in children

Management of appendiceal carcinoid tumors in children

Diagnosis and management of acute appendicitis. EAES consensus development conference 2015

Well-differentiated neuroendocrine tumor of the stomach

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