Appendiceal Adenocarcinoma Associated With Ulcerative Colitis

Abstract

Ulcerative colitis (UC) is a known risk factor for colorectal cancer, but the association between UC and appendiceal adenocarcinoma remains rare. We present a 42-year-old patient with long-standing UC who presented with acute appendicitis shortly after a routine colonoscopy. Histopathological examination revealed moderately differentiated appendiceal adenocarcinoma. The recognition of appendiceal cancer as a complication of long-standing UC warrants increased clinical awareness.

A case of appendix adenocarcinoma associated with ulcerative colitis.

“…The presence of dysplasia is an important finding for the diagnosis of UC-associated CRC. However, dysplasia of the colonic mucosa was not identified in some previously published cases of UC-associated appendix carcinoma nor in the current case (11,16,19). Furthermore, pathological examination in this case showed the presence of an adenoma component.…”

“…Appendix carcinoma is rare, and accounts for 0.4% of all gastrointestinal malignancies (15). Furthermore, UCassociated appendix carcinoma is extremely rare, and only a limited number of cases have been reported (11,16,17,19). The homology of pathogenesis between UC-associated appendix carcinoma and UC-associated CRC remains poorly understood.…”

A case of appendix adenocarcinoma associated with ulcerative colitis

“…However, dysplasia of the colonic mucosa was not identified in some previously published cases of UC-associated appendix carcinoma nor in the current case. 8,10,11 Furthermore, pathological examination in this case showed the presence of an adenoma component. These suggest that some UC-associated appendix carcinomas might develop via the noninflammatory carcinogenesis pathway.…”

“…7 Furthermore, UCassociated appendix carcinoma is extremely rare, and only a limited number of cases have been reported. [8][9][10][11] The homology of pathogenesis between UC-associated appendix carcinoma and UC-associated CRC remains poorly understood.…”

Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification

“…3 The duration and extensive feature of disease are considered as important factors associated with an increased risk of colorectal cancer in patients with UC. [4][5][6] Intense efforts have been made to elucidate the pathogeny of UC, but its molecular mechanisms are still poorly understood. Drug treatment is the first choice for UC, and the available drugs include mesalazine, corticosteroids, immunosuppressive drugs, and monoclonal antibodies to TNF-α currently in Western world.…”