Appendectomy Protects Against The Development of Ulcerative Colitis and Reduces Its Recurrence: Results of A Multicenter Case-Controlled Study in Japan

Naganuma, Makoto; Iizuka, B.; Torii, Akihiro; Ogihara, Tatsuo; Kawamura, Yo; Ichinose, Masakazu; Kojima, Yosuke; Hibi, Toshifumi

doi:10.1111/j.1572-0241.2001.03757.x

Cited by 78 publications

(61 citation statements)

References 13 publications

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“…Comparison I was conducted among 11 studies (5)(6)(7)19,25,27,28,(30)(31)(32)34) with 10,889 subjects (UC patients: 4,673; healthy control: 6,216). …”

Section: The Results Of Comparison I: Appendectomy Was a Protective Fmentioning

confidence: 99%

“…Six studies (23,24,26,28,31,33) were involved in comparison II with 4,994 subjects (appendectomy: 434; no appendectomy: 4,560). These results were displayed in figure 3.…”

Section: The Results Of Comparison Ii: Appendectomy Did Not Affect Thmentioning

confidence: 99%

“…Then, 321 completely unrelated studies and 140 reviews, letters or abstracts were excluded, and 45 articles remained. By screening of the full text, 19 studies were finally included in the present meta-analysis (5)(6)(7)(15)(16)(17)19,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The basic information of the selected studies is listed in tables I-III.…”

Section: Study Selectionmentioning

confidence: 99%

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Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Deng

Wu²

2016

Rev Esp Enferm Dig

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Objective: This study aimed to investigate the relationship between appendiceal orifice inflammation (AOI) and appendectomy and ulcerative colitis (UC) by a meta-analysis.Methods: Databases were thoroughly searched for studies on AOI and UC up to January 2016. Three comparisons were performed: a) whether the previous appendectomy was a risk factor of UC; b) influence of appendectomy on UC courses; c) influence of AOI on UC severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were the effects sizes. The merging of results and publication bias assessment were performed by using RevMan 5.3. Sensitivity analysis was conducted using Stata 12.0.Results: Nineteen studies were selected in the present study. Conclusion: In conclusion, this meta-analysis indicated appendectomy can reduce the risk of UC. But appendectomy or AOI had no influence on the severity of the disease and the effect of surgical treatment.

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“…Comparison I was conducted among 11 studies (5)(6)(7)19,25,27,28,(30)(31)(32)34) with 10,889 subjects (UC patients: 4,673; healthy control: 6,216). …”

Section: The Results Of Comparison I: Appendectomy Was a Protective Fmentioning

confidence: 99%

“…Six studies (23,24,26,28,31,33) were involved in comparison II with 4,994 subjects (appendectomy: 434; no appendectomy: 4,560). These results were displayed in figure 3.…”

Section: The Results Of Comparison Ii: Appendectomy Did Not Affect Thmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

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Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Deng

Wu²

2016

Rev Esp Enferm Dig

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“…Eine Reihe von nachfolgenden Studien (Tabelle 1) konnte die inverse Beziehung zwischen Appendektomie und Colitis ulcerosa reproduzieren, wobei wichtige Einflussfaktoren wie Tabakkonsum, Helicobacter-pylori-Status, Hygienestandards in der Kindheit und eine frühe Tonsillektomie berücksichtigt wurden [8,9,10,12,13].…”

Section: Appendektomie Und Colitis Ulcerosaunclassified

“…Auch fand sich kein Zusammenhang zwischen anderen Operationen wie Cholezystektomie oder Tonsillektomie und der Entwicklung einer Colitis ulcerosa [4,13,22].…”

Section: Introductionunclassified

Appendektomie senkt Kolitisrisiko

Buergel

Schulzke

Zeitz

2002

Chirurg

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The etiology and pathogenesis of ulcerative colitis are still unclear. There is, however, a growing consensus that the disease is characterized by a complex interaction between genetic and environmental influences. Many studies in the last few years have suggested that appendectomy reduces the risk of development and improves the course of ulcerative colitis. The underlying mechanism of this effect is unknown. The appendix seems to play a more important role in the development and modulation of the mucosal immune system than believed so far.

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Appendectomy For Ulcerative Colitis — A Therapeutic Option?

Makins¹,

Radford‐Smith²

2006

Clinical Dilemmas in Inflammatory Bowel Disease

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Appendectomy Protects Against The Development of Ulcerative Colitis and Reduces Its Recurrence: Results of A Multicenter Case-Controlled Study in Japan

Abstract: Our results indicate that appendectomy has a negative association with and perhaps a preventive effect on the development of ulcerative colitis in the Japanese population. Furthermore, appendectomy also appears to reduce the extent and recurrence of ulcerative colitis.

Cited by 78 publications

References 13 publications

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Appendektomie senkt Kolitisrisiko

Appendectomy For Ulcerative Colitis — A Therapeutic Option?

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