Appendectomy in a child with cyclic neutropenia in profound neutropenic episode

Glavan, Nedeljka; Roganović, Jelena; Glavan-Gačanin, Lana; Jonjić, Nives

doi:10.2147/tcrm.s89488

Cited by 2 publications

(4 citation statements)

References 7 publications

(11 reference statements)

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“…When surgery is required for these patients, possible worsening of the condition and severe postoperative complications should be considered due to neutropenia. Table 1 shows data for abdominal surgeries performed in emergency settings for patients with cyclic neutropenia acquired via searching PubMed using the terms “cyclic neutropenia”, and “operation” [ 1 , 4 – 6 ]. In these cases, the absolute neutrophil count was as low as 0–200/μL at the first visit.…”

Section: Discussionmentioning

confidence: 99%

“…Cyclic neutropenia is a disease that causes a neutropenic decrease in peripheral blood in a cycle of about 21 days. It is a rare hereditary disorder with an estimated incidence of 0.5–1 cases per million population and there is no gender difference in the incidence [ 1 ]. Familial cases of autosomal dominant inheritance have been reported, and it may be caused by the neutrophil elastase gene (ELA2) mutation.…”

Section: Introductionmentioning

confidence: 99%

“…The absolute neutrophil count can drop to zero, and neutropenic nadir may last for 3 to 5 days [ 2 ]. The most common infections are pharyngitis, gingivitis, and periodontitis during neutropenic nadir, but serious symptoms can occur during neutropenia [ 1 ]. Perioperative complications can be fatal for these patients; hence, perioperative management requires particular attention.…”

Section: Introductionmentioning

confidence: 99%

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Management of acute cholecystitis in patient with cyclic neutropenia: a case report

et al. 2021

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Background Cyclic neutropenia is a disease that causes a neutropenic decrease in peripheral blood in a cycle of about 21 days. It is a rare hereditary disorder with an estimated incidence of 0.5–1 cases per million population. The absolute neutrophil count can drop to zero, and neutropenic nadir may last for 3–5 days. This is a rare disease, and there are few reports of abdominal surgery in cyclic neutropenia patients; thus, we report this case of neutrophil count fluctuation and perioperative management. Case presentation A 31-year-old man with cyclic neutropenia was transferred to our hospital complaining of right season rib pain, but no rebound tenderness. His C-reactive protein was elevated (4.37 mg/L) and computed tomography revealed a large number of small stones in the gallbladder body and an incarceration in the gallbladder neck. He was diagnosed with acute cholecystitis. Ideally, surgical intervention should have been performed immediately, but because his neutrophil count was 300/μL, endoscopic naso-gallbladder drainage was performed and he was provided antibiotics until his neutrophil count increased to acceptable levels. Three days after admission, his neutrophil count had increased and laparoscopic cholecystectomy was performed. For one week after the operation, antibiotics were administered; he had an uneventful postoperative recovery. He was discharged on the seventh postoperative day and provided an oral antibiotic. Conclusions Infection can be serious in patients with cyclic neutropenia, and it is therefore, important to determine the timing of surgery and to apply appropriate perioperative management with drainage and antibiotic administration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Management of acute cholecystitis in patient with cyclic neutropenia: a case report

et al. 2021

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“…Functioning ileostomy is recommended because of poor healing and risk of infection. Mortality rates range from 2.2 to 48%, and the prognosis depends on the underlying disease and on the clinical conditions of the patient [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Neutropenic Enterocolitis Disclosing an Underlying Cyclic Neutropenia

Lahlimi

Khalil

Lahiaouni

et al. 2020

Case Reports in Pediatrics

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Neutropenic enterocolitis is a syndrome characterized by fever and abdominal pain in a neutropenic patient. It is often reported in children treated for leukemia and rarely reported in patients with other diseases. Herein, we report the case of a 9-year-old patient with a medical history of recurrent fever and mouth ulcers since the age of 4, who presented with neutropenic enterocolitis complicated with intestinal perforation which all leaded to disclose cyclic neutropenia. The patient was successfully treated by aggressive supportive care combined with surgical intervention. Neutropenic enterocolitis with possible complications should be considered and promptly managed in every neutropenic patient and may reveal a rare cause of neutropenia as cyclic neutropenia.

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Appendectomy in a child with cyclic neutropenia in profound neutropenic episode

Cited by 2 publications

References 7 publications

Management of acute cholecystitis in patient with cyclic neutropenia: a case report

Management of acute cholecystitis in patient with cyclic neutropenia: a case report

Neutropenic Enterocolitis Disclosing an Underlying Cyclic Neutropenia

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