Appendectomy for uncomplicated simple appendicitis, is it always required?

Abstract

Background: Although Appendectomy is still the classical and standard treatment for acute appendicitis, initial conservative antibiotic only treatmentfor simple un complicated cases have been proposed and tried as a feasible and effective approach.Objecti veof this study was to evaluate the efficacy and outcomes of antibiotics treatment for acute simple uncomplicated appendicitis.Methods: This is a prospective controlled non-randomized study in wh ich a total of 156 patientswhose ages range fro m 16 to 54 years old, presented with clinical d iagnosis of acute uncomplicated appendicitis were assigned for conservative antibiotics treatment wh ich consist of cefetriaxone I gram twice daily and met ronidazole infusions 500 mg in 100 ml 3 times daily for 48 t o 72 hours to be converted on oral antibiotics after clin ical imp rovement for 5 to 7 days. Patients who failed to in itial conse rvative treatmentand those who had recurred symptoms of appendicitis were presented for appendectomy.Results: Antibiotic treatment was successful and feasible in 138 (88.5%) patients Progression of the signs and symptoms despite full med ical treat ment was observed in 11 (7 %) patients during the same admission. Further 7 (4.5 %) patients showed recurrence of the symptoms during follow-up period of 6-12 months after successful init ial conservative treatment and also proceeded for appendicectomy. Conclusion:Non operative antibiotic treat ment of acute simple appendicitis is safe, feasible and effective for p roperly selected cases, thus avoiding unnecessary surgery with its possible complications

Synthesis, Characterization, antimicrobial activity and Computational Study of New 3-(1-methyl-2-((1E,2E)-3-phenylallylidene)hydrazinyl)-5-phenyl-4H-1,2,4-triazole with some transition metal ions

“…It is divisible into three isomers depending on where the nitrogen atom is located inside the ring: 1,2,3-triazole "vicinal triazole"; 1,2,4-triazole "asymmetrical-triazole"; 1,3,4-triazole "symmetrical-triazole n n" [2] . Antioxidant [3,4] , anti-inflammatory [5,6] , anticancer [6,7] , antiviral [8,9] , antifungal [10,11] , antihypertensive, and antibacterial activities [3,4] are only a few of the pharmacologically significant traits displayed by 2,4-triazole. This is important, but it is not all: it has been shown that Schiff bases derived from triazole molecules also exhibit certain biological functions [11] .…”

Incidental appendicectomy in pancreas transplantation: A single‐center study

“…Acute appendicitis is the most common abdominal surgical emergency in the world, with a lifetime risk of 8.6% in men and 6.9% in women 3 . There have been many randomized control trials and meta‐analyses examining the advantages and disadvantages of management with antibiotics versus appendicectomy in acute appendicitis 4–13 . The gold standard treatment for the majority of patients with uncomplicated appendicitis is appendicectomy 14 .…”

“…3 There have been many randomized control trials and metaanalyses examining the advantages and disadvantages of management with antibiotics versus appendicectomy in acute appendicitis. [4][5][6][7][8][9][10][11][12][13] The gold standard treatment for the majority of patients with uncomplicated appendicitis is appendicectomy. 14 However, there is no consensus on whether transplant surgeons should routinely undertake an incidental appendicectomy (IA) at the time of pancreas transplantation if it has not previously been removed.…”