Appendectomy and appendicitis do not increase colorectal cancer risk: evidence from Mendelian randomization
Wei Wei,
Juanhong Wang,
Daihua Yu
et al.
Abstract:BackgroundAcute appendicitis (AA) is one of the most prevalent acute abdominal diseases and appendectomy is the definitive treatment of appendicitis. However, whether appendicitis and appendectomy cause colorectal cancer (CRC) is controversial. The results of observational studies are contradictory, but randomized controlled trials (RCT) cannot be conducted.MethodsData of appendectomy, AA, and CRC were obtained from the IEU Open GWAS project. We selected several Genome-wide association studies (GWAS) summary s… Show more
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