Appearance of Systemic Lupus Erythematosus in Patients with Myasthenia Gravis following Thymectomy: Two Case Reports

Park, Ju Hee; Kim, Yun A; Lee, Shin Seok; Kim, Byeong C.; Kim, Myeong Kyu; Cho, Ki-Hyun

doi:10.3346/jkms.2004.19.1.134

Cited by 41 publications

(36 citation statements)

References 17 publications

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“…18 Other studies have reported polyarthritis, skin rashes, fever and cytopenias to be more common in SLE patients with thymoma. 19 Thus, it seems that although the exact mechanisms underlying both pathologies have yet to be elucidated, the association between thymoma and SLE is not incidental. 20,21 Acquired pure red cell aplasia may present as an acute self-limited disease, secondary to viral infection or drug-induced impairments, or as a chronic autoimmune form that may be associated with thymoma.…”

Section: Autoimmune Diseases and Thymomamentioning

confidence: 99%

Thymoma and autoimmunity

et al. 2011

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Section: Autoimmune Diseases and Thymomamentioning

confidence: 99%

Thymoma and autoimmunity

et al. 2011

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“…In thymectomized MG patients, hypergammaglobulinemia, B cell hyperactivity were observed with mild T cell lymphopenia [6,9,10]. This mechanism was accused of the coexistence of MG and SLE.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of thymectomy on the precipitation of SLE is still controversial [6]. In thymectomized MG patients, hypergammaglobulinemia, B cell hyperactivity were observed with mild T cell lymphopenia [6,9,10].…”

Section: Discussionmentioning

confidence: 99%

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The Course of Myasthenia Gravis with Systemic Lupus Erythematosus

Bekircan-Kurt

Kurne²,

Özdamar³

et al. 2014

Eur Neurol

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Background: Systemic lupus erythematosus (SLE) is one of the autoimmune diseases, which is rarely reported with Myasthenia Gravis (MG). In the literature, the clinical features of MG in these patients were not mentioned in detail. Here, we want to present our five patients with MG and SLE. Methods: Between 2000 and 2010, 132 MG patients were evaluated and have been followed up in our institution. Five patients had MG with SLE and eleven patients had antinuclear antibody (ANA) positivity without SLE symptoms. The clinical, laboratory findings and treatment responses were reviewed. Results: All patients had generalized MG and four of five patients experienced at least one myasthenic crisis. The response to corticosteroid was poor; consequently, they needed immunosuppressive treatments, IVIg or plasmapheresis. Although in the literature thymectomy was accused of the precipitation of SLE, in our series SLE symptoms preceded thymectomy. Conclusion: We would like to point out that MG and SLE being two autoimmune diseases may coexist. This coexistence might cause a more severe myasthenic course compared to MG alone; therefore, these patients need a close and frequent follow-up.

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“…In addition, many of these patients had high titres of a variety of autoantibodies, including anti-dsDNA, and anti-cardiolipin antibodies [10,11].…”

Section: Discussionmentioning

confidence: 99%