Appearance of Eosinophilic Granule Cells as Pathological Changes in the Uteri of Two Aged Virgin Donryu Rats

Abstract

The morphological features of cells containing eosinophilic granules (EG cells) The cells were observed in Crj/Donryu rats (Charles River Japan, Kanagawa) used for uterine carcinogenicity studies. Case 1 was an 18-mo-old female given a single intrauterine administration of 20 mg/kg body weight N-ethyl-N'-nitro-N-nitrosoguanidine via the vagina at 10 wk of age and maintained in an air-conditioned animal room under 12-hr light/12-hr dark conditions. Case 2 was a 15-mo-old female implanted with 17 ¡3-estradiol (E2)

The Metrial Gland in the Rat and Its Similarities to Granular Cell Tumors

“…Although the metrial gland has received attention in human endocrinology, immunology, and reproductive physiology literature, the metrial gland has rarely been mentioned in the veterinary or toxicologic pathology literature (Karbe et al 2000; Nagatani et al 2001; Yoshida 1997). The four most recent reports and characterizations of granular cell tumors of the rat and mouse genital tract (1) do not mention the GMG cell or metrial gland; (2) do not discuss the GMG as a possible cell involved in the proliferative lesion; and (3) do not entertain the possibility that proliferative lesions involving granular cells could be non-neoplastic (Courtney et al 1992; Markovits et al 2000; Nyska et al 1991; Veit et al 2008).…”

Spontaneous Eosinophilic Granulated Round Cell Tumors in Rats

“…11 However, the tumors in these rats arose primarily from the abdominal adipose tissue and not from the intestinal mucosa. In addition, GMG cells or GMG-like cells have been observed in the uterus in certain pathologic conditions in virgin rats 21 and in malignant fibrous histiocytic-like sarcoma in mice of both sexes. 19 These findings support the premise that the present tumors may not originate from GLs or MM cells but from GMG or GMG-like cells.…”