Apparent resistant hypertension and medication adherence

Ahmed, Mustafa I.; Calhoun, David A.

doi:10.1038/hr.2010.216

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Despite limitations, including potential for a large selection bias and limited practicality, this study importantly highlights the significant role played by poor adherence in uncontrolled hypertension. Given the findings of these two studies, there is a need to develop practical and cost-effective strategies that can be used to identify adherence in a routine clinical setting [9].…”

Section: Adherencementioning

confidence: 99%

Resistant Hypertension

Ahmed

Guichard

Calhoun

2011

Curr Cardiovasc Risk Rep

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Resistant hypertension is defined as a blood pressure that remains above goal despite the concurrent use of optimal doses of three antihypertensive agents of different classes, ideally including a diuretic. Resistant hypertension has become increasingly common in hypertensive populations around the world. In recent years there has been increased recognition and characterization of patients with resistant hypertension, and over the past year there have been several important developments in lifestyle, pharmacologic, and nonpharmacologic interventions. Although sodium restriction and adherence remain the foundation of treatment for resistant hypertension, many new pharmacologic approaches and innovative surgical interventions highlight a new and developing field for the treatment of resistant hypertension. Despite these recent advances, management of resistant hypertension remains a challenge and there continues to be a need for novel and improved therapeutic strategies.

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Section: Adherencementioning

confidence: 99%

Resistant Hypertension

Ahmed

Guichard

Calhoun

2011

Curr Cardiovasc Risk Rep

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Recent Advancements in the Treatment of Resistant Hypertension

Clark

Guichard

Calhoun

et al. 2012

Postgraduate Medicine

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The 2008 scientific statement from the American Heart Association defined resistant hypertension as blood pressure remaining above goal (< 140/90 mm Hg for the general population and < 130/80 mm Hg for patients with diabetes or renal disease) despite the concurrent use of optimal doses of 3 antihypertensive agents of different classes, ideally including a diuretic. Since then, there has been increasing recognition and characterization of patients with resistant hypertension and development of treatment strategies to treat this high-risk population. The role of aldosterone in resistant hypertension has gained increasing recognition. In particular, there has been development of a strong body of evidence for the use of spironolactone as a highly effective antihypertensive agent. Furthermore, there is increasing evidence to link aldosterone with both resistant hypertension and obstructive sleep apnea, with preliminary studies suggesting that aldosterone antagonists may potentially be effective in treating both conditions. Finally, recent work has directed increased attention toward novel invasive strategies for the treatment of resistant hypertension, specifically baroreflex activation therapy with carotid stimulation and percutaneous renal artery denervation. Initial randomized controlled trials have shown that both of these methods may be used to safely lower blood pressure, thereby providing exciting and promising new tools in the armamentarium of options to treat resistant hypertension.

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Apparent resistant hypertension and medication adherence

Cited by 2 publications

References 6 publications

Resistant Hypertension

Resistant Hypertension

Recent Advancements in the Treatment of Resistant Hypertension

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