Apparent protective effect of increased left ventricular wall thickness in an ICD population

Dogra, Vivek; Oliver, Ronald P.; Lapidus, Jodi; Balaji, Seshadri; Kron, Jack; McAnulty, John H.; Chugh, Sumeet S.

doi:10.1054/s1071-9164(03)00131-3

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…In several animal models, heart failure and LV hypertrophy has been associated with decreased K currents ( I to , I ks ), altered connexin43 expression, and an increased QT interval ,. However, increased LV mass is not uniformly related to increased ventricular arrhythmias and sudden death . The current data from GRADE suggest that an increase in LV mass was not associated with increased ICD shocks.…”

Section: Discussionmentioning

confidence: 77%

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Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function

Aleong

Mulvahill

Halder

et al. 2015

JAHA

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BackgroundReduced left ventricular (LV) ejection fraction increases the risk of ventricular arrhythmias; however, LV ejection fraction has a low sensitivity to predict ventricular arrhythmias. LV dilatation and mass may be useful to further risk-stratify for ventricular arrhythmias.Methods and ResultsPatients from the Genetic Risk of Assessment of Defibrillator Events (GRADE) study (N =930), a study of heart failure subjects with defibrillators, were assessed for appropriate implantable cardioverter-defibrillator shock and death, heart transplant, or ventricular assist device placement by LV diameter and mass. LV mass was divided into normal, mild, moderate, and severe classifications. Severe LV end-diastolic diameter had worse shock-free survival than normal and mild LV end-diastolic diameter (P =0.0002 and 0.0063, respectively; 2-year shock free, severe 74%, moderate 80%, mild 91%, normal 88%; 4-year shock free, severe 62%, moderate 69%, mild 72%, normal 81%) and freedom from death, transplant, or ventricular assist device compared with normal and moderate LV end-diastolic diameter (P<0.0001 and 0.0441, respectively; 2-year survival: severe 78%, moderate 85%, mild 82%, normal 89%; 4-year survival: severe 55%, moderate 64%, mild 63%, normal 74%). Severe LV mass had worse shock-free survival than normal and mild LV mass (P =0.0370 and 0.0280, respectively; 2-year shock free: severe 80%, moderate 81%, mild 91%, normal 87%; 4-year shock free: severe 68%, moderate 73%, mild 76%, normal 76%) but no association with death, transplant, or ventricular assist device (P =0.1319). In a multivariable Cox proportional hazards analysis adjusted for LV ejection fraction, LV end-diastolic diameter was associated with appropriate implantable cardioverter-defibrillator shocks (hazard ratio 1.22, P =0.020). LV end-diastolic diameter was associated with time to death, transplant, or ventricular assist device (hazard ratio 1.29, P =0.0009).ConclusionsLV dilatation may complement ejection fraction to predict ventricular arrhythmias.Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT02045043.

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Section: Discussionmentioning

confidence: 77%

“…13,[18][19][20] However, increased LV mass is not uniformly related to increased ventricular arrhythmias and sudden death. 21,22 The current data from GRADE suggest that an increase in LV mass was not associated with increased ICD shocks.…”

Section: Massmentioning

confidence: 91%

Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function

Aleong

Mulvahill

Halder

et al. 2015

JAHA

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“…We used the ICD database at Oregon Health and Science University to retrospectively analyse potential clinical predictors of survival with freedom from arrhythmic events (device therapies, both defibrillation or anti-tachycardia pacing) in patients with implantable defibrillators. 7 Patients who received ICDs between January 1990 and October 2002 were considered. Those patients included in this case-control study were currently followed at Oregon Health and Science University or had died during follow-up at this institution.…”

Section: Methodsmentioning

confidence: 99%

Native QRS duration predicts the occurrence of arrhythmic events in ICD recipients

et al. 2006

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“…21 22 Eccentric ventricular remodelling (dilatation), in particular, has been shown to be an important predictor of future ICD shock, whereas concentric ventricular hypertrophy may be a negative predictor. 23 Therefore, it is reasonable that BNP can predict patients most likely to develop ventricular arrhythmias amenable to ICD therapy.…”

Section: Predictors Of Icd Therapiesmentioning

confidence: 99%

Preimplantation B-type natriuretic peptide concentration is an independent predictor of future appropriate implantable defibrillator therapies

Verma

2006

Heart

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Apparent protective effect of increased left ventricular wall thickness in an ICD population

Cited by 6 publications

References 25 publications

Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function

Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function

Native QRS duration predicts the occurrence of arrhythmic events in ICD recipients

Preimplantation B-type natriuretic peptide concentration is an independent predictor of future appropriate implantable defibrillator therapies

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