Apparent Molal Volumes of Lidocaine−HCl and Procaine−HCl in Aqueous Solution as a Function of Temperature

Abstract

Apparent molal volumes of two local anesthetics, lidocaine HCl and procaine HCl, in water at (298.15, 303.15, and 310.15) K have been measured in the concentration range from (0.01 to 0.1) mol‚kg -1 . The densities were obtained with a magnetic float densimeter. The concentration dependence of V φ has been calculated using the Redlich and Meyer equation. The values of apparent molal volumes at infinite dilution, V φ 0 , the empirical constants B V , and the partial molal expansibilities, E φ 0 , were calculated. The results are interpreted in terms of competitive effects between electrostriction and hydrophobic solvation.

Densities and Speeds of Sound of Solutions of Glycine, l-Alanine, and l-Valine in Aqueous Ammonium Dihydrogen Phosphate at Different Temperatures

“…The larger values of V ϕ o at high temperature may be due to the release of the solvent from the secondary solvation layers of amino acid zwitterions to the bulk solvent, leading to the expansion of solution at higher temperature. An information about structural volume of solute in solvent and volume change of solvent in the process of shell formation around the ion , is provided by partial molar volumes, which are known to be sensitive to solute solvation. In our current study, l -valine having the higher molar mass among the three has the highest values of V ϕ o ; that is, V ϕ o increases by increasing the molar mass and size of amino acid owing to the hydrophobic − alkyl chain of the amino acids.…”

Densities and Speeds of Sound of Antibiotic Drug Chloramphenicol with l-Leucine and Glycyl-l-leucine in Aqueous Medium at T = (288.15–318.15) K: A Volumetric, Ultrasonic, and UV Absorption Study

“…Information about the structural volume of the solute in the solvent and the volume change of the solvent in the process of shell formation around the ion is provided by the apparent partial molar volumes, which are known to be sensitive to solute solvation. 47,48 By using the eq E2 of the Supporting Information, the transfer volume of amino acid/dipeptide from water to aqueous chloramphenicol solutions at infinite dilution has been calculated, and the values are reported in Table S2 of Supporting Information. For both L-leucine and glycyl-Lleucine, the obtained ΔV ϕ o values in Table S2 are all positive and increase with an increase in chloramphenicol concentration.…”

“…The dominance of solute–solvent interaction over the solute–solute interaction is submitted by the negative values of S V * as compared to positive V ϕ o values. Information about the structural volume of the solute in the solvent and the volume change of the solvent in the process of shell formation around the ion is provided by the apparent partial molar volumes, which are known to be sensitive to solute solvation. , …”

Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

“…Values of S v parameter are negative for drug in pure solvents and positive for 30, 50 and 70% v/v DMSO-water mixtures. This indicates electrolyte drug shows structure promotion effects on water and DMSO structure and structure non-promotion effect (Torres et al, 2007) indicates that solvent molecules are more structured in bulk phase than in solvation sphere (Yadav et al, 2013).…”