This article is available online at http://dmd.aspetjournals.org
ABSTRACT:Paroxetine, a selective serotonin reuptake inhibitor, is a potent inhibitor of cytochrome P450 2D6 (CYP2D6) activity, but the mechanism of inhibition is not established. To determine whether preincubation affects the inhibition of human liver microsomal dextromethorphan demethylation activity by paroxetine, we used a twostep incubation scheme in which all of the enzyme assay components, minus substrate, are preincubated with paroxetine.…
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