Apparent Focal Bone Marrow Ischemia in Patients with Marrow Disorders

Pathophysiology of bone pain: A review

“…The similar location of pain and caisson-induced bone infarcts suggest that infarcts may play a role in production of bone pain (Horvath 1978). Furthermore, focal bone marrow ischemia has also been suggested as the cause of limb pain in patients with dysplastic and proliferative marrow disorders (Vande Berg et al 1993). …”

Bone marrow necrosis in bone marrow transplantation: the role of MR imaging

“…10 However, there has only been one report of BMN in which concurrent MR imaging was described together with histological data. 11 In that paper, multifocal fluid-filled (T1-hypo and T2-hyperintense) and marginated lesions with a T1-hypointense rim were found in the pelvis and spine of three lymphoma patients.…”

Magnetic Resonance Imaging and Differential Diagnosis of Epiphyseal Osteonecrosis

“…[44][45][46] In humans, signal intensity of red marrow infarcts is low on T1-and high on T2-weighted images without recognizable margin. [47][48][49][50] They are generally not detected on T1-weighted images due to the surrounding abnormal marrow. 48,50 After contrast injection, lack of enhancement can be observed early in the disease course.…”

“…[47][48][49][50] They are generally not detected on T1-weighted images due to the surrounding abnormal marrow. 48,50 After contrast injection, lack of enhancement can be observed early in the disease course. This early phase is followed by lesion revascularization with time.…”

“…This lesion pattern has been observed in patients with hyperplastic red marrow and sickle cell disease, 47,48,51 Gaucher's disease, 52,53 or chronic neoplastic hematological disorders. 50,54,55 Differentiation between red marrow infarcts and osteomyelitis can be almost impossible and could rely more on the presence of adjacent soft tissue changes in osteomyelitis than on the analysis of the marrow changes itself. 51…”