Apparent energy deficiency in mono- and sesqui-terpene biosynthesis in peppermint

Croteau, Rodney; Burbott, Alice J.; Loomis, W.David

doi:10.1016/0031-9422(72)80083-9

Cited by 65 publications

(16 citation statements)

References 22 publications

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“…Sucrose is a relatively efficient precursor of monoterpenes in cuttings of peppermint (2), and a very suitable substrate for measuring monoterpene biosynthesis in tissue slices of marjoram. As seen in Table I (experiment 1), the youngest (smallest) leaves possessed the greatest biosynthetic capacity, and the ability to synthesize labeled volatile lipids from exogenous [U-14C]sucrose decreased rapidly as the leaves expanded.…”

Section: Resultsmentioning

confidence: 99%

Site of Monoterpene Biosynthesis in Majorana hortensis Leaves

Croteau¹

1977

Plant Physiol.

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house conditions, were used for all biosynthetic experiments. Plants were selected so the leaf pairs of each plant were of comparable ages. For studies on the effect of leaf age on biosynthetic capacity, 20 discs (5 mm diameter) from each leaf type were cut with a cork borer and placed in one chamber of a 10-cm quadrant Petri dish with 0.1 ml of an aqueous solution containing 5 ,uCi of [U-'4C]sucrose (New England Nuclear, 4.9 Ci/mol) and 20 ,ug of Tween 20. The discs were incubated in the radioactive solution for 4 hr at 30 C in a water bath shaker. For studies with epidermis, epidermal strips (approximately equal proportions of the abaxial and adaxial surface) were excised from young leaves (7 x 12 mm) in cold 0.1 M sodium phosphate buffer (pH 6.5) containing 1 mm ascorbic acid and 0.1 mm dithioerythritol. The epidermal strips and pieces of mesophyll were then rinsed in distilled H20 and patted dry. Leaf discs (5 mm) were cut from similar leaves in the same buffer, and rinsed and dried as before. Each of these tissues was then incubated with 5 ,uCi of [U-

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Section: Resultsmentioning

confidence: 99%

Site of Monoterpene Biosynthesis in Majorana hortensis Leaves

Croteau¹

1977

Plant Physiol.

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“…Burbott and Loomis (1967) proposed that the oxidation-reduction level of the monoterpenes reflects the oxidation-reduction state of the respiratory co-enzymes of the monoterpene-producing cells, and that this state depends on the balance between daytime photosynthesis and night time utilization of photosynthate. Croteau et al (1972) reported that the biosynthetic sites of monoterpenes in peppermint are energy deficient. They suggested that a lack of cofactors such as NADPH, in oil-producing glands would limit oil synthesis, oil maturation and monoterpene interconversions.…”

Section: Introductionmentioning

confidence: 98%

“…NADPH, is a necessary cofactor in the conversion of pulegone to menthone, isomenthone and menthol (Battaile et al 1968). Croteau et al (1972) suggested that cells of oil producing glands are sensitive to the type and amount nf ferment ah!^ substrates avai!ab!e tc! them f r~m adjacent ce!…”

Section: Introductionmentioning

confidence: 99%

Environmental Effects on Peppermint (Mentha piperita L.). I. Effect of Daylength, Photon Flux Density, Night Temperature and Day Temperature on the Yield and Composition of Peppermint Oil

Clark¹,

Menary²

1980

Functional Plant Biol.

102

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Long days (16 h light), high photon flux density (1200 pEm-'s-l) and high night temperature (20°C) resulted in the highest oil yield.Daylength, night temperature, day temperature and photon flux density were important interacting factors determining oil composition. The photosynthate model proposed by Burbott and Loomis (Plant Physiol., 1967, 42, 20-8) explained the effect of environmental factors with respect to pulegone, menthone and menthofuran. Factors favouring the maintenance of high levels of photosynthate resulted in high concentrations of menthone and low concentrations of pulegone and menthofuran. The photosynthate model does not explain the effect of environmental factors on several other monoterpenes.

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“…Dado que la Salvinorina A y sus derivados son diterpenos, se tiene que estos se derivan de la condensación de cuatro unidades de isopreno, las cuales conducen a la formación de compuestos con estructuras bicíclicas, tricíclicas y tetracíclicas (ver figura 5) [34,35,48].…”

Section: Metabolitos Secundarios: Terpenosunclassified

“…Biosíntesis de terpenos [32,48] Las rutas anteriores para la obtención de Salvinorina A fueron investigadas por Kutrzeba et al en 2007 [50] con rmn y hr-esi-ms, utilizando D-glucosa [1-13 C] y 1-desoxi-D-xilulosa [1-13 C;3,4-2 H 2 ] en Salvia divinorum E&J. En la figura 6, se puede apreciar un esquema simplificado de estas investigaciones, en el que se muestra el patrón de incorporación del marcado isotópico de [1-13C]-glucosa tanto por la ruta mva (puntos azules) como por la ruta mep/doxp (puntos verdes).…”

Section: Ruta Del Metileritritol Fosfatounclassified

Salvinorina A: terpeno alucinógeno presente en Salvia divinorum Epling & Játiva

2017

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Resumen. Tema y alcance: el objetivo de esta revisión es presentar los estudios químicos que se han realizado sobre Salvia divinorum E&J en estos últimos años. Características: desde la década de 1990 hasta hoy se ha incrementado la distribución y el uso de Salvia divinorum E&J para "fines recreativos", debido a sus efectos alucinógenos y a su fácil acceso. Sus efectos en el organismo se han relacionado con las de otras sustancias como: delta-9-thc en la marihuana, dmt, lsd, mdma, pcp y ketamina. Hallazgos: las investigaciones químicas realizadas en otros países sobre Salvia divinorum E&J se enfocan en los procesos de extracción, determinación, cuantificación, análisis y biosíntesis de Salvinorina A, compuesto químico al cual se le atribuye la bioactividad de la planta. Este compuesto es considerado como uno de los alucinógenos más potentes de origen natural, además de ser química y estructuralmente único, puesto que fue el primer diterpeno conocido con actividad psicoactiva. Conclusiones: la presente revisión encontró que en los últimos años las investigaciones químicas en Salvia divinorum E&J están enfocadas a través del uso de cromatografía de gases y cromatografía líquida en diversas matrices como hojas, sangre, orina y agua, con el fin de determinar la Salvinorina A y otros metabolitos presentes en la planta. En una de las investigaciones, comprobaron por rmn y hr-esi-ms que la biosíntesis de Salvinorina A está dada por la ruta metabó-lica del ácido mevalónico y la ruta del metileritritol fosfato, las cuales corresponden a las rutas metabólicas para la biosíntesis de terpenos.

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Apparent energy deficiency in mono- and sesqui-terpene biosynthesis in peppermint

Cited by 65 publications

References 22 publications

Site of Monoterpene Biosynthesis in Majorana hortensis Leaves

Site of Monoterpene Biosynthesis in Majorana hortensis Leaves

Environmental Effects on Peppermint (Mentha piperita L.). I. Effect of Daylength, Photon Flux Density, Night Temperature and Day Temperature on the Yield and Composition of Peppermint Oil

Salvinorina A: terpeno alucinógeno presente en Salvia divinorum Epling & Játiva

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