Apparent diffusion coefficient values of diffusion-weighted imaging for distinguishing focal pulmonary lesions and characterizing the subtype of lung cancer: a meta-analysis

Shen, Guohua; Jia, Zhiyun; Deng, Hongxin

doi:10.1007/s00330-015-3840-y

Cited by 62 publications

(63 citation statements)

References 49 publications

(39 reference statements)

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“…Pooled ADC values of SCLC were significantly lower than those of NSCLC, which to an extent agrees with our study (results more or less similar to ours). The potential histopathological rationale might be that SCLC has high tumoral cellularity, large nuclei, and almost no cytoplasm, all of which restrict the diffusion of water molecules thereby reducing ADC values [25].…”

Section: Discussionmentioning

confidence: 99%

Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions

Sabri

Nossair

Assal

et al. 2020

Egypt J Radiol Nucl Med

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Background: Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; concluding that ADC value is a promising noninvasive, imaging parameter that helps assess and characterize mediastinal tumors. Taking this a step forward, the primary objective of our prospective study was to investigate the potential of DW-MRI (diffusion-weighted magnetic resonance imaging) to characterize malignant mediastinal lesions using their ADC values. Thirty-three patients that underwent MRI of the chest with DWI and latter pathologically diagnosed with a malignant mediastinal lesion were included in this study. Lesions' ADC values were measured and correlated with the histopathological results. The statistical significance of differences between measurements was tested using the one-way ANOVA (analysis of variance) test; p values equal to or less than 0.05 were considered significant. Results: There was no statistically significant difference between the ADC mean values of the histopathological groups of lesions assessed with the overlap of their ADC mean values. The average ADC mean value of NHL (non-Hodgkin lymphoma) was evidently lower than that of HD (Hodgkin disease) with no overlap between their ADC mean values. DWI failed at characterizing one lesion in this study as a malignant tumor, namely an immature teratoma (germ-cell tumor). Again DWI could not be used to evaluate a mass, latter pathologically diagnosed as an angiosarcoma, because of its overall hemorrhagic nature showing no definite non-hemorrhagic soft tissue components. The aforementioned results did not differ considerably when minimum ADC was used instead of mean ADC. Conclusion: There was no statistically significant difference between the ADC values of the malignant mediastinal lesions evaluated. However, regarding lymphoma subtypes, our limited sample study of lymphoma suggested a considerable difference between the ADC values of Hodgkin disease and non-Hodgkin lymphoma.

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Section: Discussionmentioning

confidence: 99%

Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions

Sabri

Nossair

Assal

et al. 2020

Egypt J Radiol Nucl Med

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“…For lesion characterization with DWI, different methods have beans used: e.g. visual inspection of signal intensity in comparison to muscle or spinal cord, semiquantitative analysis of lesion-to-spinal cord signal intensity ratio (LSR), or quantitative determination of the apparent diffusion coefficient (ADC) [3,4,7,21,[25][26][27] . At 1.5 T, it remained unclear which analysis method should be preferred [4,26,27] .…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted Whole-body MRI at 3 Tesla for the Detection and Discrimination of Pulmonary Tumors

Mürtz¹,

Kaschner²,

Hinterthaner³

et al. 2017

JBPR

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Objective: To evaluate diffusion-weighted whole-body MRI with background body signal suppression (DWIBS) at 3.0 T for pulmonary lesion detection and characterization. Materials and Methods: 19 patients with 25 pulmonary lesions were examined with DWIBS using 2 b-values (b = 0 and 1000 s/mm²) and partly additionally with DWIBS using 3 b-values (b = 0, 50, 1000 s/mm²). DWIBS was compared to FDG PET. For characterization of hyperintense lesions by DWIBS, Lesion-to-Spinal cord Ratio (LSR) and apparent diffusion coefficient ADC were analyzed. From repeated measurements, the Coefficient of Variation (CV) was calculated. From 3-b-value data, the ADC(0,1000) and ADC(50,1000) values were compared in order to assess perfusion influences. Results: Sensitivity and specificity of detecting malignant lesions were comparable for DWIBS and FDG PET. Malignant compared to benign lesions had lower ADC(0,1000) and higher LSR values. CV of LSR was more than a factor of 8 higher than CV of ADC(0,1000) (23.9% vs 2.9%, P = 0.012). Perfusion effects were largest for metastases, medium for adenocarcinoma and benign lesions, and lowest for squamous cell carcinoma. Conclusion: DWIBS at 3.0 T is appropriate for lesion detection and characterization. ADC analysis is superior to signal intensity ratio determination with respect to repeatability. An analysis of perfusion influences provides additional information.

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“…14) There were two meta-analysis of DWI for differential diagnosis of malignancy and benignity for pulmonary nodules and masses, 15,16) and the both concluded that DWI was useful in differential diagnosis of malignancy and benignity for pulmonary nodules and masses. However, the use of DWI is restrictive for the lungs and has not become popular yet.…”

Section: Diagnosis Of Lung Cancer and The Pulmonary Nodule And Massmentioning

confidence: 99%

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

Usuda

Funazaki

Maeda

et al. 2017

ATCS

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IntroductionThis paper focuses on the latest research of diffusion-weighted magnetic resonance imaging (DWI), and deals with economic benefits, diagnostic benefits, and prospects of DWI for lung cancer. The medical cost of a magnetic resonance imaging (MRI) is 81%-84% cheaper than that of 18-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT). DWI is reported to be useful for differential diagnosis of malignancy or benignity for neoplasm in various organs. Diagnostic efficacy by DWI for pulmonary nodules and masses and the evaluation of N factor and M factor in lung cancer are equivalent to or more than that of FDG-PET/CT. The diagnostic capability of wholebody DWI (WB-DWI) for the staging of clinically operable lung cancers is equivalent to that of FDG-PET/CT and brain MRI, and WB-DWI is now becoming a more main stream procedure. Although the diagnostic performance of DWI for lung cancer may be equivalent to that of FDG-PET/CT, prospective randomized controlled trial for comparison of diagnostic efficacy between FDG-PET/CT and DWI for lung cancer is necessary for an accurate comparison. DWI may have an advantage in the aspect of the cost and diagnostic efficacy in lung cancer management.

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Apparent diffusion coefficient values of diffusion-weighted imaging for distinguishing focal pulmonary lesions and characterizing the subtype of lung cancer: a meta-analysis

Cited by 62 publications

References 49 publications

Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions

Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions

Diffusion-weighted Whole-body MRI at 3 Tesla for the Detection and Discrimination of Pulmonary Tumors

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

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