Apparent diffusion coefficient value in evaluating types, stages and histologic grading of cancer cervix

Hasan, Doaa Ibrahim; Enaba, Mones M.; El-Rahman, Hossam Mansour Abd; El-Shazely, Shrin

doi:10.1016/j.ejrnm.2015.04.006

Cited by 8 publications

(7 citation statements)

References 21 publications

(19 reference statements)

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“…This is may be attributed to the presence of necrosis and focal signal intensity changes as well as susceptibility artifacts. These result findings matched with many other studies which concluded the reported mean ADC values for both squamous cell carcinoma and adenocarcinoma cases to be less than 1 × 10 −3 mm 2 /s, averaging 0.88-0.91 × 10 −3 mm 2 /s, 0.8827 × 10 −3 mm 2 /s, and 0.72 ± 0.168 × 10 −3 mm 2 /s, respectively [23][24][25]. Also, Mahmoud SA concluded that in the present study, the mean ADC value for malignant lesions was 0.82 × 10 −3 ± 0.1 SD mm 2 /s [18], and Sherif HA et al stated that the mean ADC value of cervical carcinoma in our study was 0.82 × 10 −3 mm 2 /s [14].…”

Section: The Utility Of Dw-mri Versus Multiparametric Mri In the Characterization Of The Studied 60 Uterine Cervix Focal Lesionssupporting

confidence: 91%

The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

Osman

Mourad

2021

Egypt J Radiol Nucl Med

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Background Cervical cancer still one of the most common causes of tumor-related death in developing countries presented in younger women. In this study, we aimed to evaluate the value of diffusion-weighted MRI in early diagnosis of malignant cervical lesions, to assess metastatic adenopathy, peritoneal dissemination, and possible tumor recurrence, and determine treatment response. This study included 60 patients with abnormal vaginal bleeding and suspected cervical lesion by US. A histopathological biopsy was done. Pelvic MR with DWI and dynamic contrast-enhanced MRI were done for all patients. Results According to the histopathological findings, we divided our studied 60 patents into two groups: group I, malignant lesions (46 lesions; 76.7%), and group II, benign lesions (14 lesions; 23.3%). Multiparametric MRI could detect all cervical lesions but with poor pathologic characterization, achieving 72.37% sensitivity, 37.50% specificity, 63.33% accuracy, 76.19% PPV, and 33.33% NPV. When compared with DWI with ADC value measurements at high b value (b = 800) to MRI exam, it showed a higher diagnostic accuracy with good lesion pathological characterization that achieved 95.65% sensitivity, 71.43% specificity, 90% accuracy, 91.67 PPV, and 83.33% NPV. The mean ADC value for malignant lesions was 0.86–1.1, mean = 0.92 ± 0.71 × 10−3 mm2/s, while the mean ADC value in the benign lesion group was 1.18 ± 0.1 × 10–3 mm2/s. Conclusion Comparing DWI with ADC values measurements at high b value to the multiparametric MRI examination of the female pelvis increases the sensitivity, specificity, and diagnostic accuracy of characterization and early diagnosis of cervical malignant focal lesions and reduces the need for intravenous contrast administration.

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Section: The Utility Of Dw-mri Versus Multiparametric Mri In the Characterization Of The Studied 60 Uterine Cervix Focal Lesionssupporting

confidence: 91%

The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

Osman

Mourad

2021

Egypt J Radiol Nucl Med

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“…Hasan et al . [17] in their study showed 69.2% of squamous cell carcinoma and 30.7% of adenocarcinoma cases. Atram et al .,[18] in their series, showed 82.8% of squamous cell carcinoma, 15.8% of adenocarcinoma, and 1.4% of adenosquamous carcinoma cases.…”

Section: Discussionmentioning

confidence: 95%

“…Similar findings were seen in a study conducted by Hasan et al . [17] Atram et al . [18] reported lymph node involvement in 34% and Karunya et al .…”

Section: Discussionmentioning

confidence: 99%

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Role of apparent diffusion coefficient as a biomarker in the evaluation of cervical cancer

Dashottar

Pany

Lohia

2019

Indian Journal of Radiology and Imaging

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Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) has evolved as a major diagnostic and prognostic tool in cervical cancer. The aim of our study was to compare the change in mean apparent diffusion coefficient (ADC) value before and after concurrent chemoradiation therapy (CCRT) in carcinoma cervix thereby establishing its role as a cancer biomarker. Materials and Methods: A hospital-based prospective study was conducted in 35 patients diagnosed with cervical cancer. All 35 patients underwent pelvic MRI before and after 6 months of CCRT. The study was done over a period of 12 months. Conventional axial and sagittal T2 imaging was followed by DW-MRI. In the axial DW/ADC images at “ b -value” of 800 s/mm 2 , a circular region of interest was drawn covering more than 60% of the tumor volume to calculate the ADC values. Statistical Package for the Social Sciences (version 21.0) was used for statistical evaluation. Chi-square test, independent samples t -test, and analysis of variance were used to analyze the data. The results are depicted as frequencies (number), proportion (percentages), and mean ± standard deviation. Results: Pre-CCRT mean ADC value was 0.814 × 10 −3 mm 2 /s. Post-CCRT mean ADC value was 1.294 × 10 −3 mm 2 /s. Mean ADC value of patients having lymph node involvement and parametrial extension was significantly lower when compared with those without lymph node involvement and parametrial extension ( P = 0.001). Nonresponders with residual lesion had lower ADC values than responders with no residual lesion. An interesting and unique observation was that pre-CCRT mean ADC value of responders was higher than nonresponders. Conclusion: An increase in mean ADC value of 0.480 × 10 −3 mm 2 /s after CCRT was found to be statistically significant ( P < 0.001) thereby proving its role as an imaging biomarker in cancer cervix.

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“…Cervical cancer is one of the most common cancers in females worldwide. In the United States, its incidence and mortality rate has been declining due to the wide scale screenings, pap tests, and/or pap smear tests (25). The screening procedure can find cervical cancer early.…”

Section: Trends In Incidencementioning

confidence: 99%

Cervical Cancer Risks and Outcomes in Hispanic Women

2022

DHR Proceedings

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Apparent diffusion coefficient value in evaluating types, stages and histologic grading of cancer cervix

Cited by 8 publications

References 21 publications

The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

Role of apparent diffusion coefficient as a biomarker in the evaluation of cervical cancer

Cervical Cancer Risks and Outcomes in Hispanic Women

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