Apparent Diffusion Coefficient on Rat Brain and Nerves Intoxicated with Methylmercury

Kinoshita, Yoshimasa; Ohnishi, Akio; Kohshi, Kiyotaka; Yokota, Akira

doi:10.1006/enrs.1998.3935

Cited by 92 publications

(66 citation statements)

References 16 publications

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“…Rats intoxicated with methylmercury have shown persistent anisotropy in the optic nerve with electron microscopy confirming reductions in neurofibrils and continued integrity of the myelin sheath. 106 In this study, only the parallel ADC showed any change with methylmercury treatment and in fact it nearly doubled to a value approaching that of free water, which is rather surprising. A more recent study on the effects of disruption of the axonal cytoskeleton on water diffusion in spinal cord white matter of rats treated with the neurotoxin iminodipropionitrile demonstrated a reduction of parallel ADC with no change in perpendicular ADC.…”

Section: Neurotoxicitymentioning

confidence: 49%

The basis of anisotropic water diffusion in the nervous system – a technical review

2002

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Anisotropic water diffusion in neural fibres such as nerve, white matter in spinal cord, or white matter in brain forms the basis for the utilization of diffusion tensor imaging (DTI) to track fibre pathways. The fact that water diffusion is sensitive to the underlying tissue microstructure provides a unique method of assessing the orientation and integrity of these neural fibres, which may be useful in assessing a number of neurological disorders. The purpose of this review is to characterize the relationship of nuclear magnetic resonance measurements of water diffusion and its anisotropy (i.e. directional dependence) with the underlying microstructure of neural fibres. The emphasis of the review will be on model neurological systems both in vitro and in vivo. A systematic discussion of the possible sources of anisotropy and their evaluation will be presented followed by an overview of various studies of restricted diffusion and compartmentation as they relate to anisotropy. Pertinent pathological models, developmental studies and theoretical analyses provide further insight into the basis of anisotropic diffusion and its potential utility in the nervous system.

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Section: Neurotoxicitymentioning

confidence: 49%

The basis of anisotropic water diffusion in the nervous system – a technical review

2002

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“…It has been reported that the density and integrity of cytoskeletal proteins (microtubules and neurofilaments) affect longitudinal water diffusion. 26 Schwartz et al 27 demonstrated a positive correlation of longitudinal ADC with axon diameter in the normal rat cervical cord and explained that this was due to the inverse relationship between axon caliber and cytoskeletal protein density. These findings may explain our results of increased AD values in the upper, middle, and lower cervical cord, which may contain a higher percentage of large-diameter axons compared with the upper, middle, and lower thoracic cord.…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of the Normal Cervical and Thoracic Pediatric Spinal Cord

Saksena¹,

Middleton

Krisa

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: DTI data of the normal healthy spinal cord in children are limited compared with adults and are typically focused on the cervical spinal cord. The purpose of this study was the following: to investigate the feasibility of obtaining repeatable DTI parameters along the entire cervical and thoracic spinal cord as a function of age in typically developing pediatric subjects; to analyze the DTI parameters among different transverse levels of the cervical and thoracic spinal cord; and to examine the sex differences in DTI parameters along the cervical and thoracic spinal cord.

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“…Administering MeHg to rats resulted in disturbances in the integrities of the microtubules in the nervous system (Kinoshita et al, 1999). It has also been found that MeHg causes the abnormal migration of neurons in the brain (Choi et al, 1978).…”

Section: The Disruption Of Microtubules and S-mercurationmentioning

confidence: 99%

<i>S</i>-Mercuration of cellular proteins by methylmercury and its toxicological implications

2014

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-The accumulation of methylmercury (MeHg) through the daily consumption of large predatory fish poses potential health risks. MeHg has been found to cause Minamata disease, but the full nature of MeHg toxicity remains unclear. Because of its chemical properties, MeHg covalently binds to cellular proteins through their reactive thiols, referred to as S-mercuration, resulting in the formation of protein adducts. In this review, we summarize how the S-mercuration of cellular proteins could be involved in the major mechanisms that have been suggested to underlie MeHg toxicity. Additionally, we introduce our attempts to identify cases of S-mercuration for the research to reveal the true nature of MeHg toxicity.

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Apparent Diffusion Coefficient on Rat Brain and Nerves Intoxicated with Methylmercury

Cited by 92 publications

References 16 publications

The basis of anisotropic water diffusion in the nervous system – a technical review

The basis of anisotropic water diffusion in the nervous system – a technical review

Diffusion Tensor Imaging of the Normal Cervical and Thoracic Pediatric Spinal Cord

<i>S</i>-Mercuration of cellular proteins by methylmercury and its toxicological implications

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