Apparent Diffusion Coefficient of Fibrosis and Regenerative Nodules in the Cirrhotic Liver at MRI

Mwangi, Irene; Hanna, Robert F.; Kased, Norbert; Malek, Peter; Shiehmorteza, Masoud; Wolfson, Tanya; Gamst, Anthony; Sirlin, Claude B.

doi:10.2214/ajr.09.3484

Cited by 12 publications

(3 citation statements)

References 44 publications

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“…Previous studies demonstrated that ADC of liver tissue gradually decreases as hepatic fibrosis progresses (21, 22). Recently, Mwangi et al (23) measured and compared the ADC values of fibrous components and regenerative nodules through ex vivo and in vivo studies of cirrhotic livers. They demonstrated that the mean ADC value of fibrotic components was significantly greater than that of regenerative nodules or background cirrhotic liver parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-Weighted MRI in Intrahepatic Bile Duct Adenoma Arising from the Cirrhotic Liver

Park

Choi

2013

Korean J Radiol

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A 64-year-old male patient with liver cirrhosis underwent a CT study for hepatocellular carcinoma surveillance, which demonstrated a 1.4-cm hypervascular subcapsular tumor in the liver. On gadoxetic acid-enhanced MRI, the tumor showed brisk arterial enhancement and persistent hyperenhancement in the portal phase, but hypointensity in the hepatobiliary phase. On diffusion-weighted MRI, the tumor showed an apparent diffusion coefficient twofold greater than that of the background liver parenchyma, which suggested that the lesion was benign. The histologic diagnosis was intrahepatic bile duct adenoma with alcoholic liver cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Diffusion-Weighted MRI in Intrahepatic Bile Duct Adenoma Arising from the Cirrhotic Liver

Park

Choi

2013

Korean J Radiol

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“…A recent study indicates that fibrotic tissue and RNs have unique diffusion properties and that, contrary to the prevailing paradigm, diffusion is more restricted in RNs than in fibrosis. The lower ADC in RNs compared with ADC in fibrotic bridges may be explained by microscopic structural differences between the two tissues [20].…”

Section: Cirrhosismentioning

confidence: 99%

Cirrhosis and pre-neoplastic lesions

Grazioli¹,

Olivetti²,

Orlando³

2012

Abdom Imaging

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“…In this study, we compare IVIM parameters derived from the BLN error model with those derived from the LS error model. Direct assessment of the accuracy of parameters derived from each model is not possible, since perfusion does not occur in ex vivo liver phantoms that could otherwise be used as gold standard reference values . However, the effects of bulk motion vary across the cardiac and respiratory cycles and across the liver.…”

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confidence: 99%

Error model for reduction of cardiac and respiratory motion effects in quantitative liver DW‐MRI

Murphy

Wolfson

Gamst

et al. 2012

Magnetic Resonance in Med

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Diffusion-weighted images of the liver exhibit signal dropout from cardiac and respiratory motion, particularly in the left lobe. These artifacts cause bias and variance in derived parameters that quantify intra-voxel incoherent motion (IVIM). Many models of diffusion have been proposed, but few separate attenuation from diffusion or perfusion from that of bulk motion. The error model proposed here (Beta*LogNormal) is intended to accomplish that separation by modeling stochastic attenuation from bulk motion as multiplication by a Beta-distributed random variate. Maximum likelihood estimation with this error model can be used to derive IVIM parameters separate from signal dropout, and does not require a priori specification of parameters to do so. Liver IVIM parameters were derived for six healthy subjects under this error model and compared with least-squares estimates. Least-squares estimates exhibited bias due to cardiac and respiratory gating and due to location within the liver. Bias from these factors was significantly reduced under the Beta*LogNormal model, as was within-organ parameter variance. Similar effects were appreciable in diffusivity maps in two patients with focal liver lesions. These results suggest that, relative to least-squares estimation, the Beta*LogNormal model accomplishes the intended reduction of bias and variance from bulk motion in liver diffusion imaging.

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Apparent Diffusion Coefficient of Fibrosis and Regenerative Nodules in the Cirrhotic Liver at MRI

Abstract: The mean ADC of fibrosis is significantly greater than that of regenerative nodules both in vivo and ex vivo. The prevailing paradigm that fibrosis causes the reduced liver ADC observed in cirrhosis may need modification.

Cited by 12 publications

References 44 publications

Diffusion-Weighted MRI in Intrahepatic Bile Duct Adenoma Arising from the Cirrhotic Liver

Diffusion-Weighted MRI in Intrahepatic Bile Duct Adenoma Arising from the Cirrhotic Liver

Cirrhosis and pre-neoplastic lesions

Error model for reduction of cardiac and respiratory motion effects in quantitative liver DW‐MRI

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