Apparent central neurotransmitter receptor changes induced by low-level lead exposure during different developmental phases in the rat

Rossouw, J.P.; Offermeier, J; Rooyen, Johannes M. Van

doi:10.1016/0041-008x(87)90200-6

Cited by 47 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal exposure to lead and overall maternal body burden of lead are closely associated with lead levels in the fetus, likely because lead appears to cross the placenta freely and because pregnancy increases systemic demand for calcium, resulting in higher bone turnover and consequent lead release into the bloodstream [26, 27]. Animal studies of brain lead content have demonstrated that the blood-brain barrier is particularly ineffective against lead in the prenatal stage, becoming more effective during weaning and even more so after weaning [28, 29]. …”

Section: Pb Toxicitymentioning

confidence: 99%

Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity

Mason

Harp

Han

2014

BioMed Research International

480

286

View full text Add to dashboard Cite

Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.

show abstract

Section: Pb Toxicitymentioning

confidence: 99%

Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity

Mason

Harp

Han

2014

BioMed Research International

480

286

View full text Add to dashboard Cite

show abstract

“…Lead exposure affects the developing brain through pharmacological and morphological mechanisms and is highly age and dose dependent (Silbergeld, 1992;Goyer, 1996). Animal studies have shown, at the pharmacologic level, that prenatal exposure to lead affects neurotransmitter receptor density and affinity; the type of neurotransmitter receptor change varies depending on the timing of exposure (Rossouw, Offermeier, & van Rooyen, 1987). At the morphological level, prenatal lead exposure delays structural development of the fetal cortex (Bull, McCauley, Taylor, & Croften, 1983), and affects differentiation and synaptogenesis (Regan, 1989).…”

Section: Vulnerability Of Children To Leadmentioning

confidence: 99%

Research Review: Environmental exposures, neurodevelopment, and child mental health – new paradigms for the study of brain and behavioral effects

Rauh

Margolis

2016

Child Psychology Psychiatry

138

View full text Add to dashboard Cite

Background Environmental exposures play a critical role in the genesis of some child mental health problems. Methods We open with a discussion of children’s vulnerability to neurotoxic substances, changes in the distribution of toxic exposures, and co-occurrence of social and physical exposures. We address trends in prevalence of mental health disorders, and approaches to the definition of disorders that are sensitive to the subtle effects of toxic exposures. We suggest broadening outcomes to include dimensional measures of autism spectrum disorders, attention deficit hyperactivity disorder, and child learning capacity, as well as direct assessment of brain function. Findings We consider the impact of two important exposures on children’s mental health: lead and pesticides. We argue that longitudinal research designs may capture the cascading effects of exposures across biological systems and the full-range of neuropsychological endpoints. Neuroimaging is a valuable tool for observing brain maturation under varying environmental conditions. A dimensional approach to measurement may be sensitive to subtle sub-clinical toxic effects, permitting the development of exposure-related profiles and testing of complex functional relationships between brain and behavior. Questions about the neurotoxic effects of chemicals become more pressing when viewed through the lens of environmental justice. Conclusions Reduction in the burden of child mental health disorders will require longitudinal study of neurotoxic exposures, incorporating dimensional approaches to outcome assessment and measures of brain function. Research that seeks to identify links between toxic exposures and mental health outcomes has enormous public health and societal value.

show abstract

“…38 Experimental studies have shown that the fetal blood-brain barrier is immature and uptake of lead by fetal rat brain during gestation is greater than Copyright after birth. 13 Thus the fetus is particularly susceptible to the neurotoxic effect of lead. Effects of lead on the developing brain are both morphological and pharmacological.…”

Section: Discussionmentioning

confidence: 99%

“…Of the several neurotransmitter systems impli-cated in lead-induced neurotoxicity, 7-9 alterations in dopaminergic system and indoleaminergic parameters appear to be closely associated with the manifestations of behavioural changes. [10][11][12][13][14] Lead-induced neurochemical alterations have typically been assessed in terminal studies by measuring concentrations of neurotranmsitters and/or metabolites in brain regions. In such rodent studies, subchronic exposure to low-level lead resulted in significant reduction in dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid (HVA) in the nucleus accumbens of rats.…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental evaluation of 9-month-old infants exposed to low levels of leadin utero: involvement of monoamine neurotransmitters

Tang¹,

Huel²,

Campagna³

et al. 1999

J. Appl. Toxicol.

View full text Add to dashboard Cite

The objective of this work is to investigate the neurotoxicty of low‐level lead exposure in utero on infants and the possible involvement of dopaminergic and serotonergic neurotransmitters. The correlation analysis for cord blood lead level, the concentrations of dopamine metabolite homovanillic acid (HVA) and serotonin metabolite 5‐hydroxyindoleacetic acid (5‐HIAA) in cord plasma and the neurodevelopmental scales of infants were conducted on 244 9‐month‐old children. Both score of sociability subscale and 5‐HIAA concentration were correlated with cord blood lead level. The sociability score was negatively correlated with the concentration of HVA, whereas both the coordination score and the global score were negatively correlated with the concentration of 5‐HIAA. With partial correlation analysis, after taking HVA into account, the significant negative correlation between the sociability score and the cord blood lead level that existed in the linear correlation analysis disappeared, and the score of global scale correlated negatively with lead level in cord blood. When taking 5‐HIAA into account, the scores of all the neurodevelopmental subscales except the language subscale were significantly negatively correlated with lead level in cord blood. The results indicated that low‐level lead exposure in utero could produce a neurotoxic effect on the developing serotonergic system in infants. The neurotoxicity of low‐level lead exposure in utero may affect the sociability of infants. Serotonergic activity was shown to have a potential effect on neurodevelopmental assessment. It may interfere with the association between low‐level lead exposure in utero and other neurodevelopmental performances of 9‐month‐old children. Copyright © 1999 John Wiley & Sons, Ltd.

show abstract

Apparent central neurotransmitter receptor changes induced by low-level lead exposure during different developmental phases in the rat

Cited by 47 publications

References 20 publications

Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity

Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity

Research Review: Environmental exposures, neurodevelopment, and child mental health – new paradigms for the study of brain and behavioral effects

Neurodevelopmental evaluation of 9-month-old infants exposed to low levels of leadin utero: involvement of monoamine neurotransmitters

Contact Info

Product

Resources

About